|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity is per se associated with increased adipose expression and plasma levels of leptin, lower expression of adiponectin, and marginally elevated expression of IL-6, but PCOS does not appear to have an independent effect on the adipose expression of leptin, adiponectin, and IL-6 or the circulating adipocytokines.
|
22607892 |
2012 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The data showed that BM-MSCs from Mutant demonstrated a state of disease memory, depicted by an upregulated expression of inflammatory markers (IL-6, TNFα); increased stem cell recruitment (Oct-4, Sox-2) and proliferation rates (CD90+/CD29+, PDA, 'S' phase of cell cycle by FACS and BrdU incorporation); accelerated preadipocyte induction (Dact-1, PPARγ2) with a quantitative increase in mature adipocyte formation (Leptin); ILCAs, which were non-responsive to high glucose did confer the Obese/T2D memory in Mutants.
|
23144726 |
2012 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
We identified the increase in reactive oxygen species in combination with obesity-associated low adiponectin and high glucose and interleukin-6 as cause of the decrease in IRAK3 in THP-1 cells in vitro.
|
22272346 |
2012 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our data show that the G allele of the -174G/C IL-6 polymorphism and obesity can be considered as risk factors for the prognosis and management of psoriasis.
|
22158445 |
2012 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
White fat cells secrete adipokines that induce inflammation and obesity has been reported to be characterized by high serum levels of inflammatory cytokines such as IL-6 and TNF-α.
|
22513335 |
2012 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The hypertrophied white adipose tissue (WAT) during human obesity produces inflammatory mediators, including cytokines (IL-6 and TNFα) and chemokines ([C-C motif] chemokine ligand 2 and IL-8).
|
23372021 |
2013 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Low-grade inflammation (LGI) is a central phenomenon in the genesis of obesity and insulin-resistance characterized by IL-6 in human serum.
|
24073286 |
2013 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Interleukin-6 polymorphisms are associated with obesity and hyperglycemia in Mexican adolescents.
|
23142265 |
2013 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
CTD_human |
Obese subjects had increased levels of oxidative damage: 4-HNE (+37%; P0.03) and PC (+63%; P0.02); evidence of increased adaptive response to oxidative stress because of elevated levels of copper/zinc SOD (Cu/ZnSOD) protein content (+84%; P0.01); increased markers of inflammation: CRP (+737%; P0.0001) and IL-6 (+85%; P0.03), and these correlated with increased markers of obesity; and increased leptin (+262%; P0.0001) with lower adiponectin (-27%; P0.01) levels vs lean controls.
|
24042701 |
2013 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
When interactions between dietary fatty acids and TNFA and IL-6 SNPs on obesity and serum lipid were analyzed, both the quantity and quality of dietary fatty acids modulated the relationship between TNFA and IL-6 SNPs on obesity and serum lipid profiles, thereby impacting the association between phenotype and genotype.
|
23698162 |
2013 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Consequently, the aim of the present study was to investigate the influence of IL-6 -174G/C polymorphism on acute interleukin-6 (IL-6) and creatine kinase (CK) temporal response to ERE in elderly obese women.
|
23981903 |
2013 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We found that IL-1B rs1864169 and IL-6 rs1800796 polymorphisms may interact with diabetes, hypertension and obesity.
|
24782217 |
2014 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here we found that mice with an inactivated gene encoding the IL-6Rα chain of the receptor for IL-6 in myeloid cells (Il6ra(Δmyel) mice) developed exaggerated deterioration of glucose homeostasis during diet-induced obesity, due to enhanced resistance to insulin.
|
24681566 |
2014 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The Objective is to investigate the relationship between IL-6 (rs1554606) polymorphism and the risk of obesity in young Saudi population.
|
24395296 |
2014 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
IL-6 is a known regulator of adipose homeostasis in obesity and has been shown to be increased in primary and secondary models of lymphedema.
|
24633552 |
2014 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Haptoglobin 2-2 genotype is associated with TNF- α and IL-6 levels in subjects with obesity.
|
24868113 |
2014 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study investigated interactions between dietary fat intake and IL-6 polymorphisms on obesity and serum lipids in black and white South African (SA) women.
|
24962479 |
2014 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Obesity is most frequently associated in children with IL-6 174 C allele carriers and with IL-6 190 C allele carriers.
|
24740880 |
2014 |
|
Obesity
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Interleukin-6 CpG Methylation and Body Weight Correlate Differently in Type 2 Diabetes Patients Compared to Obese and Lean Controls.
|
26067576 |
2015 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity in WT mice fed a HFD associated with elevated serum IL-6 levels, fatty liver, upregulation of carnitine palmitoyltransferase 1 (CPT1) and signal transducer and activator of transcription-3 (STAT3), increased AMP kinase phosphorylation (p-AMPK), and downregulation of the hepatic lipogenic enzymes fatty acid synthase (FAS) and stearoyl-CoA desaturase 1 (SCD1).
|
26035386 |
2015 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
All PPAR SNPs were not associated with obesity and Met-S in the suburban population of Kampar, Malaysia, where only PPARα V162 and PPARγ2 T161 alleles were associated with plasma IL-6 and HOMA-IR, respectively.
|
26673968 |
2015 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Levels of hs-CRP (P=0.029), TNF-α (P=0.036), IL-6 (P=0.042), oxidized LDL (P=0.036), and MCP-1 (P=0.039) increased from the MHNO to MHO to MONO to MOO phenotypes.
|
25478993 |
2015 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity-associated systemic interleukin-6 promotes pre-adipocyte aromatase expression via increased breast cancer cell prostaglandin E2 production.
|
25476497 |
2015 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings suggest that aberrant DNA methylation of IL6 gene promoter may play an important role in the etiology and pathogenesis of obesity and IL6 methylation could be used as molecular biomarker for obesity risk assessment.
|
25921605 |
2015 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, IL-6 is strongly affected by factors associated with obesity accounting for its lability and responsiveness to diet, life style and contemporaneous events.
|
26086344 |
2015 |