|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We assessed the effects of IL-9, IL-13 and an IL-9/IL-13 combination, during differentiation of bronchial epithelial cells from normal (n = 6) and asthmatic (n = 8) children.
|
23671562 |
2013 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This assumption was initially confirmed by functional analyses showing that both IL-9 and Th2 cells play an important role in the pathogenesis of asthma, IgE class switch recombination, and resolution of parasitic infections.
|
22235761 |
2012 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Th2 cytokine interleukin-9 (IL-9) is one candidate gene for asthma on the basis of position cloning and animal models of airway inflammation.
|
10871433 |
2000 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin-9 (IL-9) is a pleiotropic cytokine and was primarily studied in the context of T helper 2 (T<sub>H</sub>2)-associated immuno-pathological conditions such as asthma and parasitic infections.
|
31035677 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results show that the levels of Th9 cells and their cytokine IL-9 in the peripheral blood of mice with bronchial asthma are significantly increased, suggesting that Th9 cells play important roles in the pathogenesis of asthma.
|
29456652 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin 9, a type 2 cytokine has been proposed as a key cytokine in susceptibility to asthma.
|
15051283 |
2004 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
These findings demonstrate that IL-9 is specifically upregulated after local allergen challenge in the lungs of atopic asthmatic patients.
|
12789235 |
2003 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of IL-9 was measured in 10 atopic subjects with mild asthma and 5 nonatopic healthy control subjects at baseline and 24 hours after segmental sham and allergen challenge.
|
12789235 |
2003 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, both experimental and genetic studies point to TH2 cytokines, such as IL-4, IL-13, IL-5, and IL-9, as important targets for therapeutic applications in patients with asthma.
|
11477111 |
2001 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In order to ascertain whether it is a successful translation from bench to bedside, the biological features of IL-9 were evaluated and up-to-date information regarding the role of IL-9 in different experimental murine models and human asthma were summarized.
|
28352305 |
2017 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The IL12B gene encodes the p40 chain of IL-12, a proinflammatory cytokine that antagonizes TH2 expression and hence may play a critical role in the pathogenesis of airway inflammation observed in asthma.
|
15007350 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Sequence analysis of the IL9 gene in three patients sharing a possibly conserved haplotype revealed a T113M coding polymorphism, but this variant showed no association with either serum IgE levels or asthma.
|
9328470 |
1997 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-9 targets cells of the lymphoid, myeloid and mast cell lineages, and is likely to contribute to the development of allergic and autoimmune diseases such as asthma, arthritis, multiple sclerosis and experimental autoimmune encephalomyelitis (EAE).
|
23291628 |
2013 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Accumulated eosinophils in the airways in asthma may directly react with HDM and produce IL-9 to further promote Th2-type immune responses.
|
18349591 |
2008 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We observed that plasma IL-17A and IL-9 levels were significantly increased in asthmatics when compared with controls.
|
29138487 |
2017 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cytokine-producing Th subsets including Th1 (IFN-γ), Th2 (IL-4, IL-5, IL-13), Th9 (IL-9), Th17 (IL-17), Th22 (IL-22), and T regulatory (IL-10) cells have all been suggested to play a role in the development of asthma.
|
28658556 |
2017 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The numbers of IL-9 mRNA(+) cells present in the bronchial mucosa were significantly greater in atopic asthmatics than those in normal controls (P = 0.003).
|
12047433 |
2002 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD4+ lymphocytes are the principal source of IL-9 produced by PBMCs of adult atopic asthmatics.
|
17541282 |
2007 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Th2 cytokines and asthma. Interleukin-9 as a therapeutic target for asthma.
|
11686869 |
2001 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The genes encoding IL-9 and IL-9R have recently been implicated in the genetic basis of asthma and allergy.
|
21371865 |
2011 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Studies use recombinant inbred mice to demonstrate that BHR in mouse models of asthma is associated with a genetic alteration at the IL-9 locus, where IL-9 expression in lung is strongly associated with bronchial responsiveness.
|
10329852 |
1999 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate the contribution of IL-9 to the pathogenesis of asthma, we examined the expression of IL-9 and its receptor (IL-9R) in bronchial tissue from subjects with atopic asthma (n = 10), chronic bronchitis (n = 11), and sarcoidosis (n = 9) and from atopic (n = 7) and nonatopic (n = 10) healthy control subjects.
|
10629460 |
2000 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Subjects with the dominant genotype for these IL9 polymorphisms were more likely to report a severe asthma exacerbation if exposed to increased dust mite levels.
|
25913104 |
2015 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, linkage data in human and mice have suggested that IL9 may contribute to asthma.
|
11039580 |
2000 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of sib pair linkage studies of asthma and the interleukin-9 gene (IL9).
|
11793651 |
2001 |