|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Fasting plasma leptin, triglycerides, cholesterol and phospholipids are elevated, suggesting metabolic syndrome.
|
29206867 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
MGD |
Dysregulation of the Hypothalamus-Pituitary-Adrenal Axis in Male and Female, Genetically Obese (ob/ob) Mice.
|
21554665 |
1992 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Notably, L/A outperformed individual leptin or adiponectin in discriminating a diagnosis of MS (all P < 0.02 in AUC comparisons).
|
29020116 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Phase 1.Body mass index (BMI), waist circumference, serum glucose, HbA1C, lipids, leptin, cortisol, insulin resistance index (HOMA-IR), metabolic syndrome and the frequencies of SNPs were assessed in 56 CLZ-treated patients (78.6% males).Phase 2.
|
20591628 |
2010 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Leptin promotes adequate caloric intake and glycemia in healthy lean individuals, harnessing the benefits of the ideal therapy against metabolic syndrome.
|
30792083 |
2019 |
|
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
A Receiver Operator Characteristic curve was used to identify the ability of adiponectin and leptin level to predict the MetS.
|
31341853 |
2019 |
|
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The adipokines DPP-4 and leptin in the serum can influence the body fat distribution of patients with T2MD; there is an important association of DPP-4, leptin and ADPN levels with MS, which may be used as therapeutic targets for multiple metabolism disorders of T2MD.
|
29205013 |
2019 |
|
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Patients with MetS had higher levels of leptin (14 ± 12.4) compared with those without MetS (11.2 ± 9.3 vs. 7 ± 7.1 obese and normal weight without MetS, respectively; p = .002).
|
27550773 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
A concentration of leptin > 52.18 pg/ml (AUC = 0.81, <i>p</i> < 0.0001) and resistin > 4419.27 ng/ml (AUC = 0.67, <i>p</i> = 0.049) had a good predictive value for improvement of the LVEF in the patients without MeS.
|
28721146 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Disturbances in leptin and insulin signaling pathways are related to obesity and metabolic syndrome (MS) with increased risk of diabetes and cardiovascular disease.
|
22185674 |
2011 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
At baseline, MS was observed in 24 patients, significantly associated with insulin resistance and leptin on multivariate analysis.
|
30054704 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Low vitamin D level was associated with metabolic syndrome and high leptin level in subjects with nonalcoholic fatty liver disease: a community-based study.
|
31311491 |
2019 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We studied the association of G2548A of the LEP gene and Q223R of LEPR gene polymorphisms with obesity and metabolic syndrome (MetS).
|
22734460 |
2012 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
MGD |
Leptin stimulates ischemia-induced retinal neovascularization: possible role of vascular endothelial growth factor expressed in retinal endothelial cells.
|
15331557 |
2004 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
MGD |
Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass.
|
10660043 |
2000 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
The addition of leptin and adiponectin to the regression models did not substantially change the impact of thyroid hormones on components of MS. Our data suggest that, even within the euthyroid range, excess of truncal adipose tissue is associated with variations in FT4.
|
31151171 |
2019 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
The association between SAA and leptin suggests an interaction between these two adipokines, which may have implications in inflammatory processes related to obesity and the metabolic syndrome.
|
18299466 |
2008 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Relationships of thyroid stimulating hormone (TSH) and free thyroxine (free T<sub>4</sub>) with leptin, adiponectin and the L/A ratio in euthyroid subjects were documented in 67 fasting subjects with metabolic syndrome (Mets) and 86 euthyroid subjects without MetS (TSH and free T<sub>4</sub> levels within the institutional reference range).
|
28077136 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
We conclude that epigenetic modulation of SOCS3, a gene involved in leptin and insulin signaling, may play an important role in obesity and MetS.
|
27564309 |
2016 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Leptin administration prior to tamoxifen treatment blocks development of the metabolic syndrome without affecting adipocyte loss or regeneration.
|
28065828 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Although the associations between adiponectin, leptin, resistin and metabolic abnormalities in our paediatric population were similar to those in adults, correlations of FGF21 levels with obesity, IR and MetS were the inverse of those found in adults.
|
28139438 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The CGC haplotype was less prevalent in subjects with the metabolic syndrome (P=0.0015) and was associated with lower waist circumference (P=0.007), lower hip circumference (P=0.023), lower body mass index (P=0.043) and lower leptin levels (P=0.028).
|
18071340 |
2008 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
RGD |
Metabolic syndrome triggered by high-fructose diet favors choroidal neovascularization and impairs retinal light sensitivity in the rat.
|
25380250 |
2014 |
|
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to compare metabolic aspects potentially associated with metabolic syndrome (MetS), in addition to serum leptin levels and sleep, according to exposure to night work among nursing staff.
|
29580071 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Obesity and metabolic syndrome: long-term benefits of central leptin gene therapy.
|
12582458 |
2002 |