|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We studied the association of G2548A of the LEP gene and Q223R of LEPR gene polymorphisms with obesity and metabolic syndrome (MetS).
|
22734460 |
2012 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Obesity and metabolic syndrome: long-term benefits of central leptin gene therapy.
|
12582458 |
2002 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A 1SD increase in leptin and L/A ratio z-scores or a 1SD decrease in adiponectin z-score were significantly associated with higher risk of MetS.
|
28511904 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
CRP was significantly associated (P < 0.05) with multiple features of the metabolic syndrome in twins, including body mass index (BMI), blood pressure (BP), leptin and lipids.
|
17211240 |
2007 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In obese males, the rs164147 polymorphism of the NPY gene is associated with leptin, insulin level, HOMA-IR, and an increased risk of MetS and its related phenotypes, such as central obesity and hyperglycemia.
|
27788523 |
2016 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No associations were detected between genetic variants of leptin-melanocortin genes and MS components.
|
23817596 |
2013 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Recent studies suggest that neurotherapy comprising a single central administration of recombinant adeno-associated virus vector encoding the leptin gene severely depletes fat and ameliorates the major symptoms of metabolic syndrome for extended periods in rodents.
|
16125798 |
2005 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our primary goal is to study the functional polymorphism (G-2548A) of the leptin (LEP) gene in the genetic predisposition of psoriasis, and our secondary goal is to examine factors affecting plasma leptin levels in psoriasis and to compare patients with and without metabolic syndrome (MS).
|
21569107 |
2011 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Several genes showed strong evidence for an association with MetS in patients with schizophrenia, including the fat mass and obesity associated gene (FTO), leptin and leptin receptor genes (LEP, LEPR), methylenetetrahydrofolate reductase (MTHFR) gene and the serotonin receptor 2C gene (HTR2C).
|
26621002 |
2016 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We found associations with outcomes such as increases in BMI and metabolic syndrome for variants in genes such as LEP and HTR2C.
|
28879574 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To investigate whether the G-308A polymorphism of the TNF-α gene may influence obesity, insulin resistance, fasting plasma lipids, serum leptin levels, and the incidence of metabolic syndrome.
|
21147642 |
2010 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The apolipoprotein A5 Q139X, lipoprotein lipase (LPL) Hinf I, human paraoxonase 1 (PON1) 192Arg/Gln, cholesteryl ester transfer protein (CETP) Taq1B, adiponectin 45T>G and leptin (LEP) 25CAG were genotyped by real-time polymerase chain reaction in participants with and without MetS.
|
30381540 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
After adjustment, for age and sex, the associations remained significative; LAR was also found to be significantly associated with metabolic syndrome (OR = 1.573, p value =0.000) as well as lower levels of adiponectin (OR = 0.359, p value =0.000) and higher levels of leptin (OR = 1.469, p value =0.001).
|
28878827 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Single-nucleotide polymorphisms (SNPs) rs7799039 and rs1137101 in leptin (LEP) and leptin receptor (LEPR) genes, respectively, are associated with cardiovascular disease and metabolic syndrome.
|
27310420 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In a random sample of 600 participants in the Rotterdam study, aged 55-75 years at baseline (309 men, 291 women) the relationships were studied between the presence of Trp64 Arg mutation in the beta 3-adrenergic receptor gene and fasting leptin, glucose and insulin (fasting and after an oral glucose load), and other components of the insulin resistance syndrome.
|
9828912 |
1998 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the G-308A polymorphism of the TNF-α gene may be independently associated with hypertension, leptin level and hypercholesterolemia leading to metabolic syndrome independent of Insulin resistance and hyperglycemia.
|
21616679 |
2012 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The interacting effect of central obesity with all of the other four MetS risk factors increased the proinflammatory status of adipokines (TNF-α, leptin) and decreased the anti-inflammatory status of adipokine (adiponectin).
|
30114249 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Fasting plasma leptin, triglycerides, cholesterol and phospholipids are elevated, suggesting metabolic syndrome.
|
29206867 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
MGD |
Dysregulation of the Hypothalamus-Pituitary-Adrenal Axis in Male and Female, Genetically Obese (ob/ob) Mice.
|
21554665 |
1992 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Notably, L/A outperformed individual leptin or adiponectin in discriminating a diagnosis of MS (all P < 0.02 in AUC comparisons).
|
29020116 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Phase 1.Body mass index (BMI), waist circumference, serum glucose, HbA1C, lipids, leptin, cortisol, insulin resistance index (HOMA-IR), metabolic syndrome and the frequencies of SNPs were assessed in 56 CLZ-treated patients (78.6% males).Phase 2.
|
20591628 |
2010 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Leptin promotes adequate caloric intake and glycemia in healthy lean individuals, harnessing the benefits of the ideal therapy against metabolic syndrome.
|
30792083 |
2019 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
A concentration of leptin > 52.18 pg/ml (AUC = 0.81, <i>p</i> < 0.0001) and resistin > 4419.27 ng/ml (AUC = 0.67, <i>p</i> = 0.049) had a good predictive value for improvement of the LVEF in the patients without MeS.
|
28721146 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Disturbances in leptin and insulin signaling pathways are related to obesity and metabolic syndrome (MS) with increased risk of diabetes and cardiovascular disease.
|
22185674 |
2011 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
At baseline, MS was observed in 24 patients, significantly associated with insulin resistance and leptin on multivariate analysis.
|
30054704 |
2018 |