|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
<b>Conclusions:</b> Overall, we have found that curcumin intake among patients with metabolic syndrome and related disorders was correlated with a significant reduction in BMI, weight, WC, and leptin, and a significant increase in adiponectin levels, but did not affect HR.
|
31249528 |
2019 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Leptin administration to protein-restricted dams inhibits the suppression of 11beta-HSD-2 and may be one mechanism by which the metabolic syndrome is prevented.
|
15960859 |
2005 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Leptin insufficiency in the hypothalamus due to diminished transport of leptin across the blood-brain barrier (BBB) imposed by environmental causes, such as consumption of energy-enriched diets and diminished energy expenditure, orchestrates unregulated fat accrual and the attendant disease cluster of metabolic syndrome.
|
20478430 |
2010 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
MGD |
Leptin-deficient mice are a well characterized model for analysing the metabolic syndrome.
|
25144618 |
2014 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Leptin administration prior to tamoxifen treatment blocks development of the metabolic syndrome without affecting adipocyte loss or regeneration.
|
28065828 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Leptin levels and homeostatic model assessment (HOMA) scores were significantly higher in SLE MetS<sup>+</sup> than SLE MetS<sup>-</sup> ( p = 0.018; p = 0.04).
|
29954279 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Leptin promotes adequate caloric intake and glycemia in healthy lean individuals, harnessing the benefits of the ideal therapy against metabolic syndrome.
|
30792083 |
2019 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A 1SD increase in leptin and L/A ratio z-scores or a 1SD decrease in adiponectin z-score were significantly associated with higher risk of MetS.
|
28511904 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
A concentration of leptin > 52.18 pg/ml (AUC = 0.81, <i>p</i> < 0.0001) and resistin > 4419.27 ng/ml (AUC = 0.67, <i>p</i> = 0.049) had a good predictive value for improvement of the LVEF in the patients without MeS.
|
28721146 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
A Receiver Operator Characteristic curve was used to identify the ability of adiponectin and leptin level to predict the MetS.
|
31341853 |
2019 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
MGD |
Adipocyte size distribution in ob/ob mice during preobese and obese phases of development.
|
1013161 |
1976 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adipokines such as leptin and adiponectin are thought to be important, but there is new interest in other inflammatory mechanisms related to visceral obesity, insulin resistance, and the metabolic syndrome.
|
19844182 |
2010 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adiponectin, Leptin and Inflammatory Markers in HIV-associated Metabolic Syndrome in Children and Adolescents.
|
27832021 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adiponectin, leptin and hs-CRP were significantly modified in the group with MetS (p=0.04, p=0.04, p=0.01, respectively).
|
30530892 |
2019 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
After adjustment, for age and sex, the associations remained significative; LAR was also found to be significantly associated with metabolic syndrome (OR = 1.573, p value =0.000) as well as lower levels of adiponectin (OR = 0.359, p value =0.000) and higher levels of leptin (OR = 1.469, p value =0.001).
|
28878827 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
MGD |
Altered insulin signaling in retinal tissue in diabetic states.
|
15201286 |
2004 |
|
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Although the associations between adiponectin, leptin, resistin and metabolic abnormalities in our paediatric population were similar to those in adults, correlations of FGF21 levels with obesity, IR and MetS were the inverse of those found in adults.
|
28139438 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Antipsychotics (APs) are associated with metabolic syndrome, with increases in leptin proposed as an underlying mechanism of AP-induced weight gain.
|
28980344 |
2017 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
At baseline, MS was observed in 24 patients, significantly associated with insulin resistance and leptin on multivariate analysis.
|
30054704 |
2018 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
CHGA, BMI, and leptin each displayed substantial h(2), and the traits also aggregated with several features of the metabolic syndrome (e.g., insulin resistance, blood pressure (BP), hypertension, catecholamines, and C-reactive protein (CRP)).
|
21918574 |
2012 |
|
Metabolic Syndrome X
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
CRP was significantly associated (P < 0.05) with multiple features of the metabolic syndrome in twins, including body mass index (BMI), blood pressure (BP), leptin and lipids.
|
17211240 |
2007 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
BEFREE |
Disturbances in leptin and insulin signaling pathways are related to obesity and metabolic syndrome (MS) with increased risk of diabetes and cardiovascular disease.
|
22185674 |
2011 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
MGD |
Dysregulation of the Hypothalamus-Pituitary-Adrenal Axis in Male and Female, Genetically Obese (ob/ob) Mice.
|
21554665 |
1992 |
|
Metabolic Syndrome X
|
0.600 |
Biomarker
|
disease |
MGD |
Enhanced sensitivity of pancreatic islets from preobese 2-week-old ob/ob mice to neurohormonal stimulation of insulin secretion.
|
7835283 |
1995 |
|
Metabolic Syndrome X
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Evaluation of adiponectin and leptin levels and oxidative stress in bipolar disorder patients with metabolic syndrome treated by valproic acid.
|
28875764 |
2017 |