LEP, leptin, 3952

N. diseases: 931; N. variants: 15
Disease: Metabolic Syndrome X ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker disease MGD The role of thermoregulatory thermogenesis in the development of obesity in genetically-obese (ob/ob) mice pair-fed with lean siblings. 508700 1979
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker disease MGD Adipocyte size distribution in ob/ob mice during preobese and obese phases of development. 1013161 1976
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker disease MGD Enhanced sensitivity of pancreatic islets from preobese 2-week-old ob/ob mice to neurohormonal stimulation of insulin secretion. 7835283 1995
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker disease MGD Threshold for glucose-stimulated insulin secretion in pancreatic islets of genetically obese (ob/ob) mice is abnormally low. 8360782 1993
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 GeneticVariation disease BEFREE In a random sample of 600 participants in the Rotterdam study, aged 55-75 years at baseline (309 men, 291 women) the relationships were studied between the presence of Trp64 Arg mutation in the beta 3-adrenergic receptor gene and fasting leptin, glucose and insulin (fasting and after an oral glucose load), and other components of the insulin resistance syndrome. 9828912 1998
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 AlteredExpression disease BEFREE Plasma leptin levels and plasma insulin levels have been found to be elevated in patients with essential hypertension (EH) and have been suggested to be components of the metabolic syndrome. 10539824 1999
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker disease MGD Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. 10660043 2000
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker disease BEFREE The genetic location on chromosome 6q, near marker D6S264 (6q25.2-q26), was also identified by the bivariate analysis as exerting significant pleiotropic influences on IRS-related phenotypes (e.g., LOD(eq) for traits-specific insulin and leptin was 4.1). 11283790 2001
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker disease MGD Regulation of myoplasmic Ca(2+) in genetically obese (ob/ob) mouse single skeletal muscle fibres. 12355168 2002
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 GeneticVariation disease BEFREE Obesity and metabolic syndrome: long-term benefits of central leptin gene therapy. 12582458 2002
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker disease MGD Transgenic neuronal expression of proopiomelanocortin attenuates hyperphagic response to fasting and reverses metabolic impairments in leptin-deficient obese mice. 14578285 2003
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker disease MGD Altered insulin signaling in retinal tissue in diabetic states. 15201286 2004
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker disease MGD Leptin stimulates ischemia-induced retinal neovascularization: possible role of vascular endothelial growth factor expressed in retinal endothelial cells. 15331557 2004
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 AlteredExpression disease BEFREE The current study examined the regulation of Angptl3 by leptin and insulin, both of which are key players in the metabolic syndrome. 15336575 2004
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker disease BEFREE Leptin administration to protein-restricted dams inhibits the suppression of 11beta-HSD-2 and may be one mechanism by which the metabolic syndrome is prevented. 15960859 2005
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker disease BEFREE In conclusion, this study suggests that among a large sample of French men and women, the above named SNPs in UCP3, FATP1, TNF-alpha, LEP, and GNB3 genes are not major contributors to the MS risk. 15978856 2006
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 GeneticVariation disease BEFREE Recent studies suggest that neurotherapy comprising a single central administration of recombinant adeno-associated virus vector encoding the leptin gene severely depletes fat and ameliorates the major symptoms of metabolic syndrome for extended periods in rodents. 16125798 2005
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 AlteredExpression disease BEFREE In univariate analysis, we found that there was no difference between A allele carriers and noncarriers in most of the clinical characteristics of the metabolic syndrome such as body mass index (BMI), waist-to-hip ratio, plasma leptin levels, total cholesterol, HDL- and LDL-cholesterol, triglycerides, plasma fasting glucose, insulin, and homocysteine levels. 16202847 2005
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker disease MGD Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity. 16246967 2005
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker disease BEFREE We selected six tagging single nucleotide polymorphisms (SNPs) representing 18 common variants in the protein tyrosine phosphatase-1B gene (PTPN1) and tested their effect on serum leptin, body fat, and measures of insulin sensitivity and the metabolic syndrome in a large sample of normal female Caucasian twins (n = 2,777; mean age, 47.4 +/- 12.5 years) from the St. Thomas' U.K.Adult Twin Registry. 16249458 2005
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker disease MGD Luminal leptin activates mucin-secreting goblet cells in the large bowel. 16455789 2006
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker disease MGD Leptin regulates olfactory-mediated behavior in ob/ob mice. 16549076 2006
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 AlteredExpression disease BEFREE To determine how leptin and ghrelin are expressed in the adipose tissues of obese adults undergoing gastric banding (LAGB), and to correlate tissue expression with serum concentrations and parameters of the metabolic syndrome. 16684122 2006
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker disease CTD_human Serum adiponectin and leptin levels in relation to the metabolic syndrome, androgenic profile and somatotropic axis in healthy non-diabetic elderly men. 16793964 2006
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.600 Biomarker disease MGD The leptin-deficient (ob/ob) mouse: a new animal model of peripheral neuropathy of type 2 diabetes and obesity. 17130477 2006