|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between four SNPs in the SLC22A3-LPAL2-LPA gene cluster and coronary artery disease in a Chinese Han population: a case control study.
|
23036009 |
2012 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between lipoprotein(a) genetic variants and subsequent cardiovascular events in Chinese Han patients with coronary artery disease after percutaneous coronary intervention.
|
23978127 |
2013 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This provides direct genetic evidence that variation at the apo(a) gene locus, which determines Lp(a) levels, is also a determinant of CHD risk.
|
8640397 |
1996 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.
|
19198611 |
2009 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Relatively low numbers of kringle 4 type 2 repeats in apolipoprotein(a) and specific haplotypes of the SLC22A3-LPAL2-LPA region on chromosome 6 are associated with an increased risk of coronary disease.
|
23278389 |
2013 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies: A Mendelian Randomization Analysis.
|
29926099 |
2018 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein(a) [Lp(a)] is an enigmatic lipoprotein which has been identified as a causal risk factor for coronary heart disease and calcific aortic valve disease.
|
29990619 |
2018 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genotype rs7767084-CC of the LPA gene was identified as a protective factor against CHD in females (CHD cases versus non-CHD controls: P=0.04, OR=0.21; CHD cases versus healthy controls: P=0.02, OR=0.21).
|
23653095 |
2013 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Proprotein subtilisin kexin type 9 (PCSK9) and lipoprotein (a) [Lp(a)] levels are causative risk factors for coronary heart disease.
|
29103916 |
2019 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Coronary heart disease risk correlates directly with plasma concentrations of lipoprotein(a) (Lp(a)), a low-density lipoprotein-like particle distinguished by the presence of the glycoprotein apolipoprotein(a) (apo(a)), which is bound to apolipoprotein B-100 (apoB-100) by disulfide bridges.
|
2976021 |
1988 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein(a)[Lp(a)] is a risk factor for coronary heart diseases.
|
28192139 |
2017 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.
|
19198611 |
2009 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Pro-inflammatory interleukin-1 genotypes potentiate the risk of coronary artery disease and cardiovascular events mediated by oxidized phospholipids and lipoprotein(a).
|
24530664 |
2014 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Elevated plasma lipoprotein(a) levels were associated with increased risk of cardiovascular events in Chinese patients with stable coronary artery disease.
|
29769559 |
2018 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Delayed postprandial retinyl palmitate and squalene removal in a patient heterozygous for apolipoprotein A-IFIN mutation (Leu 159-->Arg) and low HDL cholesterol level without coronary artery disease.
|
9125314 |
1996 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In these patients, low adiponectin and high lipoprotein(a) levels are found which are known to be associated with endothelial dysfunction, atherosclerosis and coronary artery disease.
|
27007665 |
2018 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We confirmed previously observed significant associations between coronary artery disease and low-frequency missense variants in the genes LPA and PCSK9.
|
26934567 |
2016 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Combined, these genetic results anticipate that, beyond low-density lipoprotein, pharmacological lowering of triglyceride-rich lipoproteins or lipoprotein(a) will reduce risk for CHD, but this remains to be proven through randomized controlled trials.
|
26892959 |
2016 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A common LPA null allele associates with lower lipoprotein(a) levels and coronary artery disease risk.
|
24925971 |
2014 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The plasma level of lipoprotein(a) (Lp(a)) is a heritable trait associated with increased coronary heart disease (CHD) risk.
|
17955342 |
2007 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism in apolipoprotein(a) kringle IV 37(Met/Thr): frequency in a London population and its association with coronary artery disease.
|
9377824 |
1997 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The inclusion of lipoprotein(a) and lymphotoxin-alfa mutations in the set of conventional risk factors showed an additive but small increase in the risk prediction of premature coronary disease.
|
24473507 |
2013 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Lipoprotein(a) and its position among other risk factors of atherosclerosis.
|
18198982 |
2008 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The copy number variation of kringle IV in the LPA gene has been strongly associated with both Lp(a) levels in plasma and risk of CHD, thereby fulfilling the main criterion for causality in a Mendelian randomization approach.
|
22998429 |
2013 |