|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between four SNPs in the SLC22A3-LPAL2-LPA gene cluster and coronary artery disease in a Chinese Han population: a case control study.
|
23036009 |
2012 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Lack of association between lipoprotein(a) genetic variants and subsequent cardiovascular events in Chinese Han patients with coronary artery disease after percutaneous coronary intervention.
|
23978127 |
2013 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This provides direct genetic evidence that variation at the apo(a) gene locus, which determines Lp(a) levels, is also a determinant of CHD risk.
|
8640397 |
1996 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.
|
19198611 |
2009 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Relatively low numbers of kringle 4 type 2 repeats in apolipoprotein(a) and specific haplotypes of the SLC22A3-LPAL2-LPA region on chromosome 6 are associated with an increased risk of coronary disease.
|
23278389 |
2013 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association of LPA Variants With Risk of Coronary Disease and the Implications for Lipoprotein(a)-Lowering Therapies: A Mendelian Randomization Analysis.
|
29926099 |
2018 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
The median follow-up was 9·9 years.Increased severity of coronary heart disease was associated with lipoprotein(a) concentrations in plasma in the highest tertile (adjusted hazard radio [HR] 1·44, 95% CI 1·14-1·83) and the presence of either LPA SNP (1·88, 1·40-2·53).
|
28566218 |
2017 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein(a) [Lp(a)] is an enigmatic lipoprotein which has been identified as a causal risk factor for coronary heart disease and calcific aortic valve disease.
|
29990619 |
2018 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genotype rs7767084-CC of the LPA gene was identified as a protective factor against CHD in females (CHD cases versus non-CHD controls: P=0.04, OR=0.21; CHD cases versus healthy controls: P=0.02, OR=0.21).
|
23653095 |
2013 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Elevated lipoprotein(a) serum levels, increasing the risk for cerebrovascular disease, may play a role in determining clinical Alzheimer's disease, but lipoprotein(a) elevation in centenarians, in the absence of other coronary artery disease risk factors, appears as a positive survival factor.
|
17990970 |
2007 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Lipoprotein (a) [Lp(a)] is an independent but moderate, predictor for coronary heart disease (CHD) prevalence and severity.
|
28078997 |
2017 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Proprotein subtilisin kexin type 9 (PCSK9) and lipoprotein (a) [Lp(a)] levels are causative risk factors for coronary heart disease.
|
29103916 |
2019 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Coronary heart disease risk correlates directly with plasma concentrations of lipoprotein(a) (Lp(a)), a low-density lipoprotein-like particle distinguished by the presence of the glycoprotein apolipoprotein(a) (apo(a)), which is bound to apolipoprotein B-100 (apoB-100) by disulfide bridges.
|
2976021 |
1988 |
|
Coronary heart disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
As the levels of lipoprotein(a) [Lp(a)], an important and independent cardiovascular risk factor, are high in polygenic hypercholesterolemia (PH), we investigated plasma Lp(a) levels and apolipoprotein(a) [apo(a)] phenotypes in relation to occurrence of CHD events in PH patients.
|
15553596 |
2004 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein(a)[Lp(a)] is a risk factor for coronary heart diseases.
|
28192139 |
2017 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.
|
19198611 |
2009 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Pro-inflammatory interleukin-1 genotypes potentiate the risk of coronary artery disease and cardiovascular events mediated by oxidized phospholipids and lipoprotein(a).
|
24530664 |
2014 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Elevated plasma lipoprotein(a) levels were associated with increased risk of cardiovascular events in Chinese patients with stable coronary artery disease.
|
29769559 |
2018 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Delayed postprandial retinyl palmitate and squalene removal in a patient heterozygous for apolipoprotein A-IFIN mutation (Leu 159-->Arg) and low HDL cholesterol level without coronary artery disease.
|
9125314 |
1996 |
|
Coronary heart disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Some reports have suggested that plasma lipoprotein(a) [Lp(a)] levels may explain such variation and that FH subjects deficient in LDL receptors, especially those with coronary heart disease, tend to have elevated Lp(a) levels.
|
8548413 |
1996 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In these patients, low adiponectin and high lipoprotein(a) levels are found which are known to be associated with endothelial dysfunction, atherosclerosis and coronary artery disease.
|
27007665 |
2018 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Elevated plasma concentrations of lipoprotein(a) [Lp(a)] are an independent, and possibly causal, risk factor for atherothrombotic diseases including coronary heart disease.
|
30316749 |
2019 |
|
Coronary heart disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Comparison of Lipoprotein(a) levels between elderly and middle-aged men with coronary artery disease.
|
17460176 |
2007 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
CTD_human |
High plasma concentrations of lipoprotein(a) [Lp(a)], a covalent low-density lipoprotein-apolipoprotein(a) [apo(a)] complex, are associated with coronary heart disease and stroke.
|
10484779 |
1999 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
These results suggest that APO(a) phenotyping might be used in subjects with hyperlipoproteinemia a as a powerful marker to assess the risk of premature CHD because heterozygous status, mainly when both isoforms are equally expressed, is associated with higher cardiovascular risk.
|
11944029 |
2002 |