|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Coronary heart disease risk correlates directly with plasma concentrations of lipoprotein(a) (Lp(a)), a low-density lipoprotein-like particle distinguished by the presence of the glycoprotein apolipoprotein(a) (apo(a)), which is bound to apolipoprotein B-100 (apoB-100) by disulfide bridges.
|
2976021 |
1988 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Lipoprotein(a) [Lp(a)] is a macromolecular complex found in human plasma that combines structural elements from the lipoprotein and blood clotting systems and that is associated with premature coronary heart disease and stroke.
|
2530631 |
1989 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Intermediate-density lipoproteins (IDLs) and lipoprotein (a) are highly atherogenic species that each normally account for up to 10% to 15% total LDL cholesterol but may be disproportionately elevated in pathologic states and may therefore contribute disproportionately to coronary disease risk in certain patients.
|
1994714 |
1991 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The value of lipoprotein (a) [Lp(a)] in the prediction of coronary artery disease risk very early in life remains to be established in different racial groups.
|
1829398 |
1991 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Prevalence of lipoprotein (a) [Lp(a)] excess in coronary artery disease.
|
1827234 |
1991 |
|
Coronary heart disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Lipoprotein (a) (Lp(a)) is a low density lipoprotein-like particle which contains the plasminogen-like apolipoprotein a. Lp(a) levels are elevated in patients with atherosclerotic coronary artery disease.
|
1824942 |
1991 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
This could be explained by the observed rise of lipoprotein (a) between age 2 and 13 years, which was much more pronounced in the group with parents who had CHD.
|
1929512 |
1991 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein(a) phenotypes, Lp(a) concentration and plasma lipid levels in relation to coronary heart disease in a Chinese population: evidence for the role of the apo(a) gene in coronary heart disease.
|
1541665 |
1992 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein(a). A genetic risk factor for premature coronary heart disease.
|
1534588 |
1992 |
|
Coronary heart disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
An investigation of the influence of selected factors on the clinical expression of the FH Afrikaner-1 mutation in this family indicated that it was especially the elevated apolipoprotein (a) levels, in addition to low levels of high density lipoprotein cholesterol and raised triglyceride and apolipoprotein B levels, that were associated with a greater risk of developing CHD.
|
8370148 |
1993 |
|
Coronary heart disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The relation of LDL receptor activity to lipoprotein(a) plasma concentration in patients without coronary artery disease.
|
8187228 |
1994 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Lipoprotein(a) and coronary heart disease.
|
8187239 |
1994 |
|
Coronary heart disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Lipoprotein(a) levels were strongly associated with coronary artery disease in five of seven prospective studies but were not associated in two of the four largest studies.
|
8185133 |
1994 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Current data do justify treatment of CHD patients with lipoprotein(a) excess with niacin because niacin has been shown to lower lipoprotein(a) levels as well as lower CHD risk mortality in random CHD patients.
|
8283932 |
1994 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the I/D polymorphism of the ACE gene is an important independent risk factor for coronary artery disease and is more predictive that lipoprotein(a).
|
7882471 |
1995 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in lipoprotein (a) levels in families enriched for coronary artery disease is determined almost entirely by the apolipoprotein (a) gene locus.
|
7825589 |
1995 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic effect of apolipoprotein(a) and apolipoprotein E polymorphisms on plasma quantitative risk factors for coronary heart disease in American black women.
|
8546757 |
1995 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This provides direct genetic evidence that variation at the apo(a) gene locus, which determines Lp(a) levels, is also a determinant of CHD risk.
|
8640397 |
1996 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Delayed postprandial retinyl palmitate and squalene removal in a patient heterozygous for apolipoprotein A-IFIN mutation (Leu 159-->Arg) and low HDL cholesterol level without coronary artery disease.
|
9125314 |
1996 |
|
Coronary heart disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Some reports have suggested that plasma lipoprotein(a) [Lp(a)] levels may explain such variation and that FH subjects deficient in LDL receptors, especially those with coronary heart disease, tend to have elevated Lp(a) levels.
|
8548413 |
1996 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Correlation of toddlers' serum lipoprotein(a) concentration with parental values and grandparents' coronary heart disease: the STRIP baby study.
|
8740296 |
1996 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Lipoprotein(a)-apheresis in the secondary prevention of coronary heart disease.
|
10168548 |
1996 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Apo(a) protein sizes were a significant predictor, and the genotype homozygous for the 8 (TTTTA)-repeats was a possible predictor, for the degree of atherosclerosis in CHD.
|
8782849 |
1996 |
|
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Serum lipoprotein (a) concentrations (Lp(a)) are largely under genetic control, and are strong predictors of coronary heart disease.
|
8800499 |
1996 |
|
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism in apolipoprotein(a) kringle IV 37(Met/Thr): frequency in a London population and its association with coronary artery disease.
|
9377824 |
1997 |