|
Malignant neoplasm of breast
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our study is the first to report an association between a miR-SNP in MIR145 and breast cancer risk in individuals of Caucasian background.
|
26577090 |
2015 |
|
Breast Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our study is the first to report an association between a miR-SNP in MIR145 and breast cancer risk in individuals of Caucasian background.
|
26577090 |
2015 |
|
Esophageal Neoplasms
|
0.370 |
GeneticVariation
|
group |
BEFREE |
In addition, the risk-score model -0.0053*log<sub>2</sub>(<i>CADM2</i>)+0.0168*log<sub>2</sub>(<i>SERPINE1</i>)-0.0073*log<sub>2</sub>(ADAMTS9-AS2)+0.0905*log<sub>2</sub>(PVT1)+0.0047*log<sub>2</sub>(hsa-miR372)-0.0193*log<sub>2</sub>(hsa-miR145), (log<sub>2</sub>[gene count]) could improve diagnosis of EC with an AUC of 0.988.
|
30643460 |
2019 |
|
Esophageal Neoplasms
|
0.370 |
GeneticVariation
|
group |
BEFREE |
The combined expression of miR-143 and miR-145 was significantly associated with the risk for esophageal cancer.
|
22457808 |
2012 |
|
Malignant neoplasm of esophagus
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
In addition, the risk-score model -0.0053*log<sub>2</sub>(<i>CADM2</i>)+0.0168*log<sub>2</sub>(<i>SERPINE1</i>)-0.0073*log<sub>2</sub>(ADAMTS9-AS2)+0.0905*log<sub>2</sub>(PVT1)+0.0047*log<sub>2</sub>(hsa-miR372)-0.0193*log<sub>2</sub>(hsa-miR145), (log<sub>2</sub>[gene count]) could improve diagnosis of EC with an AUC of 0.988.
|
30643460 |
2019 |
|
Malignant neoplasm of esophagus
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
The combined expression of miR-143 and miR-145 was significantly associated with the risk for esophageal cancer.
|
22457808 |
2012 |
|
Malignant tumor of colon
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Most notable associations were for hsa-miR-145-3p [hazard ratio (HR) 2.94, 95% confidence interval (CI) 1.54, 5.61], and hsa-miR-9-3p (HR 10.28, 95% CI 1.31, 80.84) with colon cancer and hsa-miR-335-5p (HR 0.17, 95% CI 0.05, 0.54) for rectal cancer. hsa-miR-374a-5p, hsa-miR-570-3p and hsa-miR-18a-5p significantly reduced the hazard of dying for all cases, regardless of tumor site.
|
25484364 |
2015 |
|
Malignant tumor of colon
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rodent and human sporadic and ulcerative colitis (UC)-associated colon cancers were examined for miR-143 and miR-145.
|
21653642 |
2011 |
|
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, miR-145 might be used as a therapeutic target in the treatment of colorectal cancer patients with BRAF V600E mutation.
|
24248543 |
2014 |
|
Colorectal Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In total, 14 DEMs were found in CRC.By bioinformatics analysis, 5 DEMs (miR-145, miR-497, miR-30a, miR-31, and miR-20a) and 8 TFs (ELK4 (ETS-family transcription factor), myeloblastosis proto-oncogene like (MYBL)1, MYBL2, CEBPA, PPARA, PPARD, PPARG, and endothelial PAS domain protein (EPAS1)) appeared to be associated with CRC and were therefore used to construct miRNA-TF-gene networks.
|
30985693 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The high levels of expression of mature MIR143 and mature MIR145 were associated with recurrence of metastasis in ESCC patients (P < 0.05).
|
21453382 |
2011 |
|
Neoplasm Metastasis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
To mimic in vivo cancer microenvironment, hypoxia and serum deprivation were used to induce metastasis in breast (MCF-7, MDA-MB-231, MDA-MB-453), prostate (PC3, LNCaP, DU145), lung (A549, NCIH82,) cancer cell lines and noncancerous cell lines of the coresponding tissues (MCF10A, RWPE-1, MRC-5). miR-145-3p expression levels were determined by qRT-PCR.
|
31195093 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
After the full establishment of metastases on day 21, six animals were treated with three intravenous doses of miR-145 (on days 21, 24 and 27), and six were injected with scramble miRNA as controls.
|
29858716 |
2018 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
To search for tumor-associated mutations that could affect processing and expression of mature miRNAs, a panel of 91 cancer-derived cell lines was analyzed for sequence variations in 15 miRNAs implicated in tumorigenesis by virtue of their known target transcripts (let-7 family targeting oncogenic Ras) or their localization to sites of frequent chromosomal instability (miR-143, miR-145, miR-26a-1, and miR-21).
|
16778182 |
2006 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Comparison of the possible combinations of DLBCL-, FL- and LN resulted in specific DLBCL- and FL-signatures, which include miRNAs with previously published function in haematopoiesis (MIRN150 and MIRN155) or tumour development (MIRN210, MIRN10A, MIRN17-5P and MIRN145).
|
18537969 |
2008 |
|
Adenocarcinoma of lung (disorder)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Most interestingly, an obvious inhibition of cell growth was observed in the EGFR mutant lung adenocarcinoma after transfection of hsa-pre-miR-145.
|
19493678 |
2009 |
|
Malignant neoplasm of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analysis was conducted to assess the association between polymorphisms in the promoter of miR-143/miR-145 and risk of lung cancer females.
|
31314552 |
2019 |
|
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analysis was conducted to assess the association between polymorphisms in the promoter of miR-143/miR-145 and risk of lung cancer females.
|
31314552 |
2019 |
|
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Most notable associations were for hsa-miR-145-3p [hazard ratio (HR) 2.94, 95% confidence interval (CI) 1.54, 5.61], and hsa-miR-9-3p (HR 10.28, 95% CI 1.31, 80.84) with colon cancer and hsa-miR-335-5p (HR 0.17, 95% CI 0.05, 0.54) for rectal cancer. hsa-miR-374a-5p, hsa-miR-570-3p and hsa-miR-18a-5p significantly reduced the hazard of dying for all cases, regardless of tumor site.
|
25484364 |
2015 |
|
Primary malignant neoplasm of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analysis was conducted to assess the association between polymorphisms in the promoter of miR-143/miR-145 and risk of lung cancer females.
|
31314552 |
2019 |
|
Malignant neoplasm of colon and/or rectum
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, miR-145 might be used as a therapeutic target in the treatment of colorectal cancer patients with BRAF V600E mutation.
|
24248543 |
2014 |
|
Arteriosclerosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
To this end, we examined whether AS is associated with the miR-145 rs353291 polymorphism and specific rs353291 alleles.
|
31585905 |
2020 |
|
Atherosclerosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
To this end, we examined whether AS is associated with the miR-145 rs353291 polymorphism and specific rs353291 alleles.
|
31585905 |
2020 |
|
Esophageal carcinoma
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The combined expression of miR-143 and miR-145 was significantly associated with the risk for esophageal cancer.
|
22457808 |
2012 |
|
Esophageal carcinoma
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In addition, the risk-score model -0.0053*log<sub>2</sub>(<i>CADM2</i>)+0.0168*log<sub>2</sub>(<i>SERPINE1</i>)-0.0073*log<sub>2</sub>(ADAMTS9-AS2)+0.0905*log<sub>2</sub>(PVT1)+0.0047*log<sub>2</sub>(hsa-miR372)-0.0193*log<sub>2</sub>(hsa-miR145), (log<sub>2</sub>[gene count]) could improve diagnosis of EC with an AUC of 0.988.
|
30643460 |
2019 |