|
Hepatitis
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Attenuation of miR-145 activity by anti-miR-145 triggered liver inflammation and increased serum chemokines in C57BL/6 J mice.
|
30941422 |
2020 |
|
Inflammatory disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
miR-145 improves metabolic inflammatory disease through multiple pathways.
|
30941422 |
2020 |
|
Malignant neoplasm of larynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression levels of miRNA-145 and miRNA-218 in serum of patients with laryngeal cancer decreased, the higher the expression levels of miRNA-145 and miRNA-218 in serum of patients with laryngeal cancer were, the better the prognosis was. miRNA-145 and miRNA-218 were used as indicators of assessing the prognosis of patients with laryngeal cancer.
|
31289552 |
2019 |
|
Intracranial Aneurysm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, qRT-PCR analysis confirmed that miR-145-5p and miR-29a-3p were up-regulated in IA samples.
|
31597886 |
2019 |
|
Dermatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that miR-145-5p negatively regulates proliferation and chemokine secretion of NHEKs by targeting MLK3, and downregulation of miR-145-5p contributes to skin inflammation in psoriasis lesions.
|
30269330 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, the effect of miR-145 in IDD was elucidated.
|
30797016 |
2019 |
|
Down Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
An integrated analysis of miR and mRNA expression in the thymus in Down syndrome is reported in the present study. miR‑30c, miR‑145, miR‑183 and their targets may serve important roles in the pathogenesis and development of complications in Down syndrome.
|
31257513 |
2019 |
|
Disorder of eye
|
0.010 |
Biomarker
|
group |
BEFREE |
Overall, our findings indicate that miR-145 is a novel regulator of TMOD3-dependent cytoskeletal architecture and pathological angiogenesis and a potential target for development of treatments for neovascular eye disorders.
|
30981984 |
2019 |
|
Hyperlipidemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
<b>Results:</b> Comparative with control group, in hypertension associated with hyperlipidemia the investigated miRNA expression profiles were different: (i) in plasma, the levels of all investigated miRNAs were significantly increased, the highest enhances being noticed for miR-21,-146a,-221,-143,-34a, and miR-204; (ii) in platelets, the expressions of almost all miRNAs were significantly elevated, remarkable for miR-126,-146a,-223,-222, and miR-214, while levels of miR-143, miR-10a, and miR-145 were significantly reduced; (iii) in PMVs, numerous miRNAs were found to have significantly increased levels, especially miR-222,-221,-210, and miR-34a, whereas expressions of various miRNAs as miR-223,-214,-146a,-143,-10a, and miR-145 were significantly decreased.
|
31850358 |
2019 |
|
Arthropathy
|
0.010 |
Biomarker
|
group |
BEFREE |
Accumulating evidence suggests that microRNA-145 (miR-145) plays an important role in osteoarthritis (OA), which is a chronic progressive joint disease.
|
31637891 |
2019 |
|
Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
MiRNAs associated with specific complications included: i) neuropathy (miR-873-5p, miR-125a-5p, miR-145-3p and miR-99b-5p); ii) nephropathy (miR-1249-3p, miR-193a-5p, miR-409-5p, miR-1271-5p, miR-501-3p, miR-148b-3p and miR-9-5p); and iii) retinopathy (miR-143-3p, miR-1271-5p, miR-409-5p and miR-199a-5p).
|
30926524 |
2019 |
|
Prolactinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Xenograft mouse model was constructed to analyze whether miR-145-5p could reverse bromocriptine resistance in prolactinoma in vivo.
|
30370446 |
2019 |
|
Psoriasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
To explore the role of miR-145-5p in psoriasis.
|
30269330 |
2019 |
|
Subarachnoid Hemorrhage
|
0.010 |
Biomarker
|
disease |
BEFREE |
Applying an anti-miRNA targeting approach in SAH does not seem to be a feasible approach because miRNA-143 and miRNA-145 are not upregulated following SAH.
|
31425342 |
2019 |
|
Hallopeau-Siemens Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings expand the knowledge on miRNA-driven pathomechanisms implicated in RDEB fibrosis. miR-145-5p and its targets (e.g.
|
30816994 |
2019 |
|
Synovial Cyst
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study is to investigate the role of miR-145-5p in high glucose-induced RGC injury.
|
31272285 |
2019 |
|
Intervertebral disc disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
Here, the effect of miR-145 in IDD was elucidated.
|
30797016 |
2019 |
|
Cholangiocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the activation of STAT1 by miR-145-5p was specifically observed in gallbladder carcinoma and cholangiocarcinoma but not in hepatocellular carcinoma cells.
|
30886199 |
2019 |
|
acute aortic dissection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
miR-145 expression was downregulated in aortic dissection tissues and was associated with the survival of patients with AAD.
|
30900421 |
2019 |
|
Hantavirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
The aim of this work was to investigate the underlying mechanism of miR-145 in regulating the proliferation of pulmonary microvascular endothelial cells (PMVECs) and angiogenesis in HPS via plasminogen activator inhibitor-1 (PAI-1).
|
31649116 |
2019 |
|
Erythroblastosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Next, we identified ETS1 (v-ets avian erythroblastosis virus E26 oncogene homolog 1) as the target of miR-145.
|
31219744 |
2019 |
|
Solid Neoplasm
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The expression of tumor suppressor miR-145 is reduced in various cancer cell lines, containing both solid tumors and blood malignancies.
|
30396077 |
2019 |
|
Hyperplastic Polyp
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
It can be concluded that, in the process of MP infection, the expression of miR-145 is stimulated to negatively regulate the fibrosis-promoting pathway of TGF-β/Smad.
|
31637903 |
2019 |
|
Adenocarcinoma of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, we found that LINC00491 positively regulates SERPINE1 expression through sponging miR-145 and promoting the proliferation, migration, and invasion of colon adenocarcinoma cells, thus playing an oncogenic role during colon adenocarcinoma pathogenesis.
|
31496744 |
2019 |
|
Hematologic Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
These results uncover the importance of Fli-1 in leukemogenesis, a Fli-1-miR145 autoregulatory loop and new anti-Fli-1 diterpenoid agents for the treatment of diverse hematological malignancies overexpressing this transcription factor.
|
30741932 |
2019 |