MIR145, microRNA 145, 406937

N. diseases: 366; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0740302
Disease: 5q-syndrome
5q-syndrome 		0.080 Biomarker disease BEFREE Moreover, combined loss of miR-145 and RPS14 cooperates to alter erythroid-megakaryocytic differentiation in a manner similar to the 5q- syndrome. 21873545 2011
CUI: C0740302
Disease: 5q-syndrome
5q-syndrome 		0.080 Biomarker disease BEFREE Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype.Nat.Med.16(1), 49-58 (2009). 20469997 2010
CUI: C0740302
Disease: 5q-syndrome
5q-syndrome 		0.080 Biomarker disease BEFREE Recent evidence suggests that haploinsufficiency of the microRNA genes miR-145 and miR-146a may contribute to the thrombocytosis seen in the 5q- syndrome. 22571696 2012
CUI: C0740302
Disease: 5q-syndrome
5q-syndrome 		0.080 Biomarker disease BEFREE Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. 19898489 2010
CUI: C0740302
Disease: 5q-syndrome
5q-syndrome 		0.080 Biomarker disease BEFREE Macrophages, regulatory cells of erythropoiesis and the innate immune response, were significantly increased in Rps14/Csnk1a1/miR-145/146a deficient mice as well as in 5q- syndrome patient bone marrows and showed activation of the innate immune response, reflected by increased expression of S100A8, and decreased phagocytic function. 30651631 2019
CUI: C0740302
Disease: 5q-syndrome
5q-syndrome 		0.080 GeneticVariation disease BEFREE The megakaryocytic and platelet phenotype of the 5q-syndrome has been attributed to heterozygous deletion of miR145 and miR146a. 21943668 2011
CUI: C0740302
Disease: 5q-syndrome
5q-syndrome 		0.080 Biomarker disease BEFREE In 5q- syndrome haploinsufficiency of the ribosomal gene RPS14 appears to cooperate with loss of two micro-RNAs miR-145 and miR-146 to induce key features of the disease. 20211165 2010
CUI: C0740302
Disease: 5q-syndrome
5q-syndrome 		0.080 Biomarker disease BEFREE Other mouse modeling data suggest that haploinsufficiency of the microRNA genes miR-145 and miR-146a may contribute to the thrombocytosis seen in the 5q- syndrome. 20733155 2010
CUI: C0241868
Disease: acute aortic dissection
acute aortic dissection 		0.010 AlteredExpression disease BEFREE miR-145 expression was downregulated in aortic dissection tissues and was associated with the survival of patients with AAD. 30900421 2019
CUI: C2215101
Disease: Acute cerebral ischemia
Acute cerebral ischemia 		0.010 AlteredExpression disease BEFREE Results of further <i>in vivo</i> study revealed that anti-miR-145-5p administration brought about increasing expression of Nurr1 and reduction of infarct volume in acute cerebral ischemia. 29209166 2017
CUI: C0751956
Disease: Acute Cerebrovascular Accidents
Acute Cerebrovascular Accidents 		0.010 AlteredExpression disease BEFREE In the subchapter "miRNAs in acute stroke", we will provide insight into recent knowledge from animal and human studies concerning miRNA profiling in acute stroke and their expression dynamics in brain tissue and extracellular fluids (roles of, e.g. let-7 family, miR-21, miR-29 family, miR-124, miR-145, miR-181 family, miR-210 and miR-223). 26663183 2015
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.010 Biomarker disease BEFREE In particular, miR-133a/b (5 studies), miR-208a/b (6 studies), and miR-499 (7 studies) were well studied and found to be significant diagnostic and/or prognostic markers across different cardiovascular disease progression stages. miR-1 and miR-145b are potential biomarkers of ACS; miR-1 with higher sensitivity for all acute myocardial infarction (AMI), and miR-145 for STEMI and worse outcome of AMI. 27357636 2016
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia 		0.010 AlteredExpression disease BEFREE We found that miR-143 and miR-145 expression is significantly repressed in primary AML patient samples as compared to neutrophils of healthy donors. 22093444 2012
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.050 Biomarker disease BEFREE Receiver Operating Characteristic (ROC) analysis indicated that miR-17-5p, miR-126-5p, and miR-145-3p showed considerable diagnostic efficiency for AMI. 30833907 2019
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.050 AlteredExpression disease BEFREE Chloroquine diphosphate (5 µM) inhibited the regulatory effect of miRNA‑145 upregulation on autophagy to adjust cell apoptosis, in the in vitro model of AMI. 29956747 2018
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.050 GeneticVariation disease BEFREE In a multivariable linear regression analysis, AMI and heart failure were independently associated with lower Ln_miRNA-145 (estimate -0.99, standard error [SE] 0.28; P= 0.001 and estimate -0.62, SE 0.21; P= 0.004). 28051023 2017
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.050 Biomarker disease BEFREE In particular, miR-133a/b (5 studies), miR-208a/b (6 studies), and miR-499 (7 studies) were well studied and found to be significant diagnostic and/or prognostic markers across different cardiovascular disease progression stages. miR-1 and miR-145b are potential biomarkers of ACS; miR-1 with higher sensitivity for all acute myocardial infarction (AMI), and miR-145 for STEMI and worse outcome of AMI. 27357636 2016
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.050 AlteredExpression disease BEFREE Noticeably, the expression levels of miR-24, miR-23a and miR-145 were significantly down-regulated in AMI<sup>+</sup>AKI<sup>+</sup> patients compared to those in AMI<sup>+</sup>AKI<sup>-</sup> patients. 31039814 2019
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.020 Biomarker group BEFREE We successfully verified the expression of selected miRNAs using real-time reverse transcription-PCR assays for mature miRNAs, whereas in situ hybridization was used to detect the accumulation of miR-145 and miR-320 in normal epithelial cells and adenocarcinoma cells. 18676867 2008
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.020 Biomarker group BEFREE An increased expression of miR-21 was found in the tumour-associated stroma with the most dramatic increase from adenoma to adenocarcinoma, while the number of positive miR-145 fibroblast-like cells in the normal lamina propria (stroma) decreased in a stepwise manner throughout the normal-adenoma-adenocarcinoma sequence. 26465597 2015
CUI: C0338106
Disease: Adenocarcinoma of colon
Adenocarcinoma of colon 		0.010 AlteredExpression disease BEFREE Furthermore, we found that LINC00491 positively regulates SERPINE1 expression through sponging miR-145 and promoting the proliferation, migration, and invasion of colon adenocarcinoma cells, thus playing an oncogenic role during colon adenocarcinoma pathogenesis. 31496744 2019
CUI: C0279628
Disease: Adenocarcinoma Of Esophagus
Adenocarcinoma Of Esophagus 		0.020 AlteredExpression disease BEFREE Finally, we demonstrate that expression of miR-145 in esophageal adenocarcinoma cell line (SK-GT-4) enhances tumor growth and metastasis in a NOD/SCID xenograft model. 29632636 2018
CUI: C0279628
Disease: Adenocarcinoma Of Esophagus
Adenocarcinoma Of Esophagus 		0.020 AlteredExpression disease BEFREE MiR-145 expression accelerates esophageal adenocarcinoma progression by enhancing cell invasion and anoikis resistance. 25551563 2014
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.100 Biomarker disease BEFREE And miR-145-5p tended to show better diagnostic performance in lung squamous cell carcinoma than in lung adenocarcinoma. 28347234 2017
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.100 GeneticVariation disease BEFREE Most interestingly, an obvious inhibition of cell growth was observed in the EGFR mutant lung adenocarcinoma after transfection of hsa-pre-miR-145. 19493678 2009