|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
It was predominantly found in MLL-rearranged AML (13/47), monosomy 7 (2/3), or FAB M6/7 (6/10), and mutually exclusive with core-binding factor AML, t(15;17), and NPM1 mutations.
|
20357826 |
2010 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Among them, the translocation t(9;11)(p22;q23), KMT2A-MLLT3, is the most common abnormality accounting for approximately 22% of KMT2A rearrangements in infant AML cases.
|
28595195 |
2017 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fluorescent in situ hybridization and reverse transcriptase polymerase chain reaction analyses revealed an MLL/GAS7 chimera identical to the one previously described in AML.
|
16956839 |
2006 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases.
|
12805060 |
2003 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This case report helps to better understand the rare but potentially severe impact of KMT2A- FLNA fusions in infants with AML to improve prognostic stratification of therapy and clinical management.
|
28253492 |
2016 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Initiation of MLL-rearranged AML is dependent on C/EBPα.
|
24367003 |
2014 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Translocations involving the mixed lineage leukemia (MLL) gene, localized at 11q23, frequently occur in pediatric acute myeloid leukemia (AML).
|
20861917 |
2010 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we isolated chimeric cDNAs between the MLL and a gene designated MLLT3 at 9p22 from a cDNA library of an IMS-M1 cell line with a t(9;11)(p22;q23) translocation, a representative karyotypic abnormality seen in acute monocytic leukemia.
|
8414510 |
1993 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Rearrangement of MLL in a patient with congenital acute monoblastic leukemia and granulocytic sarcoma associated with a t(1;11)(p36;q23) translocation.
|
15621793 |
2005 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Cytogenetic and molecular analysis of the acute monocytic leukemia cell line THP-1 with an MLL-AF9 translocation.
|
11066077 |
2000 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
MLL-MLLT10 fusion in acute monoblastic leukemia: variant complex rearrangements and 11q proximal breakpoint heterogeneity.
|
15262427 |
2004 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Gene expression profiles of t(8;16)(p11;p13) pediatric AML cases clustered close to, but distinct from, MLL-rearranged AML.
|
23974201 |
2013 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Is t(10;11)(p11.2;q23) involving MLL and ABI-1 genes associated with congenital acute monocytic leukemia?
|
12547160 |
2002 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We report a case of secondary acute myelogenous leukemia (AML) with 11q23 cytogenetic abnormality and mixed lymphoid leukemia (MLL) gene expression in a patient treated with Y90 labeled anti-CD20 antibody (Zevalin).
|
12539741 |
2002 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
A 2-year-old female with AML with MLL rearrangement presented with CNS infiltration.
|
28658145 |
2017 |
|
Acute monocytic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MLL/SEPTIN6 chimeric transcript from inv ins(X;11)(q24;q23q13) in acute monocytic leukemia: report of a case and review of the literature.
|
12874781 |
2003 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The MYO1F, unconventional myosin type 1F, gene is fused to MLL in infant acute monocytic leukemia with a complex translocation involving chromosomes 7, 11, 19 and 22.
|
15897884 |
2005 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Progression from myelodysplastic syndrome with monosomy 7 to acute monoblastic leukemia with MLL gene rearrangement.
|
9594441 |
1998 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
RT-PCR and sequencing revealed that exon 7 of MLL was fused to exon 2 of MAML2 in the AML and MDS cells.
|
17551948 |
2007 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Analysis of t(9;11) chromosomal breakpoint sequences in childhood acute leukemia: almost identical MLL breakpoints in therapy-related AML after treatment without etoposides.
|
12619163 |
2003 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here, we report a second case--an infant acute monocytic leukemia (AML M5b)--with an MLL/GRAF fusion.
|
15382263 |
2004 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
For the vegetable and fruit index, there were significant or near-significant inverse linear trends for all leukemias combined, ALL(MLL+), and AML(MLL-).
|
15767345 |
2005 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The MLL/EB1 cells grew more slowly owing to increased apoptosis in vitro and induced acute monocytic leukemia with an incomplete penetrance and longer survival in vivo.
|
30974389 |
2019 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
LHGDN |
Is t(10;11)(p11.2;q23) involving MLL and ABI-1 genes associated with congenital acute monocytic leukemia?
|
12547160 |
2002 |
|
Acute monocytic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Segmental amplification of MLL gene associated with high expression of AURKA and AURKB genes in a case of acute monoblastic leukemia with complex karyotype.
|
20303016 |
2010 |