|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases.
|
12805060 |
2003 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
AML with chromosomal translocations involving the mixed lineage leukemia (MLL) gene are usually associated with poor survival.
|
23798388 |
2013 |
|
Acute monocytic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MLL/SEPTIN6 chimeric transcript from inv ins(X;11)(q24;q23q13) in acute monocytic leukemia: report of a case and review of the literature.
|
12874781 |
2003 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
MLL-MLLT10 fusion in acute monoblastic leukemia: variant complex rearrangements and 11q proximal breakpoint heterogeneity.
|
15262427 |
2004 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
MLL fusion genes are a predominant feature of acute leukemias in infants and in secondary acute myeloid leukemia (AML) associated with prior chemotherapy with topo-II poisons.
|
16688745 |
2006 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
A 2-year-old female with AML with MLL rearrangement presented with CNS infiltration.
|
28658145 |
2017 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A bone marrow examination confirmed the diagnosis of acute monocytic leukemia with a t(11;19) MLL-ELL fusion transcript.
|
19405140 |
2009 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A case of acute monocytic leukemia with t(11;17) involving a rearrangement of MLL-1 and a region proximal to the RARA gene.
|
8194047 |
1994 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
A novel AF9 breakpoint in MLL-AF9-positive acute monoblastic leukemia.
|
18000862 |
2008 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Among them, the translocation t(9;11)(p22;q23), KMT2A-MLLT3, is the most common abnormality accounting for approximately 22% of KMT2A rearrangements in infant AML cases.
|
28595195 |
2017 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Analysis of MLL-derived transcripts in infant acute monocytic leukemia with a complex translocation (1;11;4)(q21;q23;p16).
|
10700861 |
2000 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Analysis of t(9;11) chromosomal breakpoint sequences in childhood acute leukemia: almost identical MLL breakpoints in therapy-related AML after treatment without etoposides.
|
12619163 |
2003 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Both patients with IDH1 mutations had AML-M0 subtype and MLL-partial tandem duplication.
|
23365461 |
2013 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
C-terminal BRE might be an important contributor to this program because in a case with relapsed AML, we observed an ins(11;2) fusing CHORDC1 to BRE at the region where intragenic transcription starts in KMT2A-rearranged and KAT6A-CREBBP AML.
|
28871137 |
2018 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Combinatorial treatment against miR-17-5p and miR-19a-3p of the miR-17∼92 cluster dramatically reduces colony forming ability of MLL-fusion containing cell lines relative to non-MLL acute myeloid leukemia (AML) controls.
|
27123834 |
2016 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Combined present results and literatures suggest that AML with the MLL-SEPTIN6 fusion gene is a subset of infant AML, which differentiate into the myeloid lineage, although AML with other MLL fusion genes is capable of differentiating into the myelomonocytic or monocytic lineage.
|
11809673 |
2002 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Concurrent presence of FLT3-internal tandem duplication (ITD) is observed in 25% of patients with MLL-PTD AML.
|
22674806 |
2012 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Cytogenetic and molecular analysis of the acute monocytic leukemia cell line THP-1 with an MLL-AF9 translocation.
|
11066077 |
2000 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
FLT3 and MLL intragenic abnormalities in AML reflect a common category of genotoxic stress.
|
12791658 |
2003 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Fluorescence in situ hybridization (FISH) analysis in a case of infant acute monocytic leukemia M5 revealed a complex rearrangement between chromosomes 10 and 11, leading to the disruption of the MLL gene.
|
12127405 |
2002 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fluorescent in situ hybridization and reverse transcriptase polymerase chain reaction analyses revealed an MLL/GAS7 chimera identical to the one previously described in AML.
|
16956839 |
2006 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Following the development of therapy-related leukemia after 1 year, evolution of therapy-related AML-M4 with t(11;17)(q23;q25) and the rearrangement of the MLL gene were observed, while AML/MTG8 disappeared.
|
10905055 |
2000 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
For the vegetable and fruit index, there were significant or near-significant inverse linear trends for all leukemias combined, ALL(MLL+), and AML(MLL-).
|
15767345 |
2005 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Gene expression profiles of t(8;16)(p11;p13) pediatric AML cases clustered close to, but distinct from, MLL-rearranged AML.
|
23974201 |
2013 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Generation of a MLL-AF9-specific stem cell model of acute monocytic leukemia.
|
27185517 |
2017 |