|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Rearrangements of the human trithorax gene (MLL, HRX, Htrx-1, All-1) were studied by Southern blotting in blast cells stored at presentation from 65 adults with de novo acute myelomonocytic (AML-M4) and acute monocytic leukemia (AML-M5).
|
7949133 |
1994 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A case of acute monocytic leukemia with t(11;17) involving a rearrangement of MLL-1 and a region proximal to the RARA gene.
|
8194047 |
1994 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Molecular rearrangements of the MLL gene are present in most cases of infant acute myeloid leukemia and are strongly correlated with monocytic or myelomonocytic phenotypes.
|
8282816 |
1994 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we isolated chimeric cDNAs between the MLL and a gene designated MLLT3 at 9p22 from a cDNA library of an IMS-M1 cell line with a t(9;11)(p22;q23) translocation, a representative karyotypic abnormality seen in acute monocytic leukemia.
|
8414510 |
1993 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, 29 cases of adult acute myeloid leukemia (AML) were analyzed to determine the frequency of MLL gene rearrangement.
|
8616778 |
1996 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Of 16 acute myeloid leukemia patients with trisomy 11 and rearrangement of MLL reported, our patient was the youngest in age and the only one with AMoL.
|
9209466 |
1997 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Two acute monocytic leukemia (AML-M5a) cell lines (MOLM-13 and MOLM-14) with interclonal phenotypic heterogeneity showing MLL-AF9 fusion resulting from an occult chromosome insertion, ins(11;9)(q23;p22p23).
|
9305600 |
1997 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Progression from myelodysplastic syndrome with monosomy 7 to acute monoblastic leukemia with MLL gene rearrangement.
|
9594441 |
1998 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The mixed lineage leukemia (MLL) gene located at chromosome band 11q23 is frequently rearranged in patients with therapy-related acute monocytic leukemia who received topoisomerase II inhibitors.
|
10648423 |
2000 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Analysis of MLL-derived transcripts in infant acute monocytic leukemia with a complex translocation (1;11;4)(q21;q23;p16).
|
10700861 |
2000 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Molecular analysis of the rearranged genome and chimeric mRNAs caused by the t(6;11)(q27;q23) chromosome translocation involving MLL in an infant acute monocytic leukemia.
|
10719372 |
2000 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Screening for MLL tandem duplication in 387 unselected patients with AML identify a prognostically unfavorable subset of AML.
|
10803509 |
2000 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Following the development of therapy-related leukemia after 1 year, evolution of therapy-related AML-M4 with t(11;17)(q23;q25) and the rearrangement of the MLL gene were observed, while AML/MTG8 disappeared.
|
10905055 |
2000 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Cytogenetic and molecular analysis of the acute monocytic leukemia cell line THP-1 with an MLL-AF9 translocation.
|
11066077 |
2000 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We analyzed one patient with de novo acute monoblastic leukemia with t(11;14)(q23;q24) and identified that a human homologue of gephyrin (human gephyrin) fused with MLL.
|
11289145 |
2001 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These genetic subgroups seem to display biological heterogeneity: MLL copy gain or amplification in association with 5q- was detected only in AML patients and was significantly associated with extremely short survival (median overall survival: 30 days, P = 0.0102).
|
11746988 |
2002 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Combined present results and literatures suggest that AML with the MLL-SEPTIN6 fusion gene is a subset of infant AML, which differentiate into the myeloid lineage, although AML with other MLL fusion genes is capable of differentiating into the myelomonocytic or monocytic lineage.
|
11809673 |
2002 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
MLLT10 (previously called AF10) is a moderately common MLL fusion partner predominantly occurring in acute monoblastic leukemia (AML-M5).
|
11896537 |
2002 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Fluorescence in situ hybridization (FISH) analysis in a case of infant acute monocytic leukemia M5 revealed a complex rearrangement between chromosomes 10 and 11, leading to the disruption of the MLL gene.
|
12127405 |
2002 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We report a case of secondary acute myelogenous leukemia (AML) with 11q23 cytogenetic abnormality and mixed lymphoid leukemia (MLL) gene expression in a patient treated with Y90 labeled anti-CD20 antibody (Zevalin).
|
12539741 |
2002 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Is t(10;11)(p11.2;q23) involving MLL and ABI-1 genes associated with congenital acute monocytic leukemia?
|
12547160 |
2002 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
LHGDN |
Is t(10;11)(p11.2;q23) involving MLL and ABI-1 genes associated with congenital acute monocytic leukemia?
|
12547160 |
2002 |
|
Acute monocytic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Analysis of t(9;11) chromosomal breakpoint sequences in childhood acute leukemia: almost identical MLL breakpoints in therapy-related AML after treatment without etoposides.
|
12619163 |
2003 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
FLT3 and MLL intragenic abnormalities in AML reflect a common category of genotoxic stress.
|
12791658 |
2003 |
|
Acute monocytic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases.
|
12805060 |
2003 |