|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Chlorotoxin can specifically bind to matrix metalloproteinase 2 (MMP-2), which are overexpressed in the glioma.
|
30670934 |
2018 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Taken together, our results demonstrate the efficacy of p-MMP-2 in inhibiting radiation-enhanced tumor invasion and progression and suggest that it may act as a potent adjuvant for radiotherapy in glioma patients.
|
21698233 |
2011 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Matrix metalloproteinase-2 activation modulates glioma cell migration.
|
9410885 |
1997 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The Impact of MMP-2 and Its Specific Inhibitor TIMP-2 Expression on the WHO Grade and Prognosis of Gliomas in Chinese Population: a Meta-Analysis.
|
26729052 |
2017 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Levels of the proteinase matrix metalloproteinase-2 (MMP-2) are highly increased in gliomas.
|
18438431 |
2008 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
These observations suggest that glioma induces MMP-2 and utilizes its activity in the host tissue to support angiogenesis and to maintain angioarchitecture.
|
12220955 |
2002 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our studies on increased anoikis sensitization in matrix metalloproteinase-2 (MMP-2)-knockdown 4910 and 5310 human glioma xenograft cells were interestingly correlated with p21-activated kinase 4 (PAK4) inhibition, prompting us to further investigate the role of PAK4 in glioma.
|
23254288 |
2012 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Treatment of glioma cell lines with recombinant Nodal (rNodal) increased matrix metalloproteinase 2 (MMP-2) secretion and cell invasiveness.
|
20383200 |
2010 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our research emphasized the suppressive function of miR-93-5p in glioma by targeting MMP2, thus providing some novel experimental basis for the treatment of glioma.
|
31773703 |
2019 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Taken together, these results suggest that Migfilin is a critical regulator in cellular motility by driving the EGFR-MMP-2 feedback loop, and may be considered as a potential therapeutic target in glioma.
|
29203120 |
2017 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Microglial MT1-MMP in turn activates glioma-derived pro-MMP-2 and promotes glioma expansion, as shown in an ex vivo model using MT1-MMP-deficient brain tissue and a microglia depletion paradigm.
|
19617536 |
2009 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
The results of RT-PCR showed that the mRNA level of MMP-2 in 9L glioma cells was higher than that of MMP-9, and the mRNA expression of MMP-9 was increased along with the growth of malignant gliomas.
|
17437609 |
2007 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Here, we attempt to investigate the exact molecular mechanism of how MMP-2 depletion leads to apoptosis in glioma xenograft cell lines.
|
21573233 |
2011 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our data demonstrate that Diaph1 is highly expressed in human glioma, plays a significant role in glioma cell migration, and can influence the expression and activity of MMP2 and MMP9 indirectly in human glioma cell lines U87 and U251.
|
29035824 |
2017 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of MMP-2 and MMP-9 indicates poor prognosis in glioma recurrence.
|
31545229 |
2019 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Ad5CMV-PTEN transfer into the glioma cell lines lacking the wild-type gene product decreased the levels of matrix metalloproteinase (MMP)-2 mRNA and inhibited the enzymatic activities of MMP-2 and MMP-9.
|
16773187 |
2006 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Ionizing radiation activates EGFR signalling and enhances MMP-2 secretion, suggesting that the molecular pathways involved may contribute to the invasiveness and malignant behaviour of glioma cells and help to explain the response of gliomas to ionizing radiation.
|
21289335 |
2011 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The FITC-iCREKA was proved to have significantly higher cellular uptake in the glioma U87 cells in the presence of activated MMP-2 than that in absence of activated MMP-2 by cells fluorescence test <i>in vitro</i>.
|
29686590 |
2018 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
CD34-PAS staining was carried out to observe VM formation, and immunohistochemistry was used to determine the expression levels of Beclin-1, HIF-1α, VEGF and MMP2 in 105 patients with primary glioma.
|
29278874 |
2018 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we have demonstrated that the RNAi-mediated downregulation of MMP-2 induces apoptosis in the 4910 human glioma xenograft cell line.
|
19724922 |
2009 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The ability of glioma cells to invade the surrounding tissue has been attributed to the expression of matrix metalloproteinase-2 (MMP-2) in human gliomas.
|
21483125 |
2011 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, this compound suppressed the expression of matrix metalloproteinase-2, a key effector of glioma cell invasion, regulated by fibulin-3.
|
23660683 |
2013 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our data suggest that SERPINB1 negatively regulates glioma cell migration and invasion probably by abrogating the expression of MMP-2 and the activation of FAK.
|
24968089 |
2015 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
LHGDN |
Furthermore, key components (i.e., uPAR, uPA, and pro-MMP-2) were contributed principally by astrocytes, whereas the U251N glioma cells provided plasminogen.
|
12764090 |
2003 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Delineation of MMP-2 regulation may have implications for development of new therapeutic strategies to arrest glioma invasion.
|
10506168 |
1999 |