|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Taken together, our results demonstrate the efficacy of p-MMP-2 in inhibiting radiation-enhanced tumor invasion and progression and suggest that it may act as a potent adjuvant for radiotherapy in glioma patients.
|
21698233 |
2011 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Matrix metalloproteinase-2 activation modulates glioma cell migration.
|
9410885 |
1997 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The Impact of MMP-2 and Its Specific Inhibitor TIMP-2 Expression on the WHO Grade and Prognosis of Gliomas in Chinese Population: a Meta-Analysis.
|
26729052 |
2017 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Levels of the proteinase matrix metalloproteinase-2 (MMP-2) are highly increased in gliomas.
|
18438431 |
2008 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our studies on increased anoikis sensitization in matrix metalloproteinase-2 (MMP-2)-knockdown 4910 and 5310 human glioma xenograft cells were interestingly correlated with p21-activated kinase 4 (PAK4) inhibition, prompting us to further investigate the role of PAK4 in glioma.
|
23254288 |
2012 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Treatment of glioma cell lines with recombinant Nodal (rNodal) increased matrix metalloproteinase 2 (MMP-2) secretion and cell invasiveness.
|
20383200 |
2010 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our research emphasized the suppressive function of miR-93-5p in glioma by targeting MMP2, thus providing some novel experimental basis for the treatment of glioma.
|
31773703 |
2019 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Taken together, these results suggest that Migfilin is a critical regulator in cellular motility by driving the EGFR-MMP-2 feedback loop, and may be considered as a potential therapeutic target in glioma.
|
29203120 |
2017 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Microglial MT1-MMP in turn activates glioma-derived pro-MMP-2 and promotes glioma expansion, as shown in an ex vivo model using MT1-MMP-deficient brain tissue and a microglia depletion paradigm.
|
19617536 |
2009 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Here, we attempt to investigate the exact molecular mechanism of how MMP-2 depletion leads to apoptosis in glioma xenograft cell lines.
|
21573233 |
2011 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
CD34-PAS staining was carried out to observe VM formation, and immunohistochemistry was used to determine the expression levels of Beclin-1, HIF-1α, VEGF and MMP2 in 105 patients with primary glioma.
|
29278874 |
2018 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
LHGDN |
Furthermore, key components (i.e., uPAR, uPA, and pro-MMP-2) were contributed principally by astrocytes, whereas the U251N glioma cells provided plasminogen.
|
12764090 |
2003 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Delineation of MMP-2 regulation may have implications for development of new therapeutic strategies to arrest glioma invasion.
|
10506168 |
1999 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Furthermore, CCR7 was shown to mediate TGF-β1-induced glioma cancer cell migration by activating matrix metalloproteinase 2 (MMP2)/9.
|
28817313 |
2017 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In spheroid and Boyden chamber migration assays, inhibition of MMP-2 activity using a specific MMP-2 inhibitor and blocking of integrin alpha(v)beta(3) abrogated glioma cell migration stimulated by TGF-beta2.
|
19033423 |
2009 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Similarly, relatively little is known about the relationship of miR-140-5p, vascular endothelial growth factor A, and matrix metalloproteinase-2 in glioma progression.
|
28443475 |
2017 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Imbalance of TIMP-2/MMP-2 was observed using immunoprecipitation analysis in a glioma cell line.
|
10895974 |
2000 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Activities of MMP-2 and MMP-9 are the best predictors of glioma cell invasion.
|
11409528 |
2001 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
CCL5-directed glioma invasion and increases in MMP-2 were suppressed after inhibition of p-CaMKII.
|
31593589 |
2020 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Taken together, our data provide evidence that IGFBP2 contributes to glioma progression in part by enhancing MMP-2 gene transcription and in turn tumor cell invasion.
|
12907597 |
2003 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Quantitative RT-PCR and gelatin zymography showed that gelatinase-A in glioma specimens was higher than in normal tissue; these were significantly elevated in low grade gliomas and remained elevated in GBMs.
|
10206300 |
1999 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Analysis by Cox model suggested that tumor diameter, pathological grade and MMP-2 were independent prognostic factors for glioma (P<0.05).
|
30675244 |
2019 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Matrix metalloproteinase 2, critical in human glioma migration and invasion, was down-regulated upon Girdin reduction and led to decreased invasion in vitro and in vivo.
|
25060559 |
2014 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Addition of dexamethasone or ectopic expression of wild-type MKP-1 suppressed the SNP-stimulated MMP-2 activation and glioma cell invasiveness in U87MG cells.
|
18652821 |
2008 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Knockdown of MMP-2 using MMP-2 small interfering RNA (pM) in human glioma xenograft cell lines 4910 and 5310 decreased cell proliferation compared with mock and pSV (scrambled vector) treatments, as determined by 5-bromo-2'-deoxyuridine incorporation, Ki-67 staining and clonogenic survival assay.
|
22349830 |
2013 |