|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Matrix metalloproteinase 2, critical in human glioma migration and invasion, was down-regulated upon Girdin reduction and led to decreased invasion in vitro and in vivo.
|
25060559 |
2014 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Matrix metalloproteinase-2 activation modulates glioma cell migration.
|
9410885 |
1997 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Activities of MMP-2 and MMP-9 are the best predictors of glioma cell invasion.
|
11409528 |
2001 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Ad5CMV-PTEN transfer into the glioma cell lines lacking the wild-type gene product decreased the levels of matrix metalloproteinase (MMP)-2 mRNA and inhibited the enzymatic activities of MMP-2 and MMP-9.
|
16773187 |
2006 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Addition of dexamethasone or ectopic expression of wild-type MKP-1 suppressed the SNP-stimulated MMP-2 activation and glioma cell invasiveness in U87MG cells.
|
18652821 |
2008 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Analysis by Cox model suggested that tumor diameter, pathological grade and MMP-2 were independent prognostic factors for glioma (P<0.05).
|
30675244 |
2019 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
By contrast, the level of TIMP- 1 mRNAs was not altered significantly and that of TIMP-2 was reduced mildly by the HGF/SF treatment, suggesting that HGF/SF may eventually modulate a balance between MMP-2 and TIMPs in favor of the proteinase activity in the glioma cell microenvironment.
|
10389763 |
1999 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
By RT-PCR, glioma cell invasion assay showed that the expression of MMP-2 was increased in ppGalNAc-T2-knockdown cells, while the expression of MMP-9 and TGF-β1 was decreased in ppGalNAc-T2-overexpressing cells at the mRNA level.
|
21874244 |
2012 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
CCK-8, Transwell migration Assay and Wound-healing assay were appraisal assays for cell proliferation and migration. qRT-PCR and western blot were performed to test the expression of miR-4262, MMP2, MMP13 and LATS1 in glioma cancers tissues and cancer cells.
|
31831299 |
2020 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
CCL5-directed glioma invasion and increases in MMP-2 were suppressed after inhibition of p-CaMKII.
|
31593589 |
2020 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
CD34-PAS staining was carried out to observe VM formation, and immunohistochemistry was used to determine the expression levels of Beclin-1, HIF-1α, VEGF and MMP2 in 105 patients with primary glioma.
|
29278874 |
2018 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Chlorotoxin can specifically bind to matrix metalloproteinase 2 (MMP-2), which are overexpressed in the glioma.
|
30670934 |
2018 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Delineation of MMP-2 regulation may have implications for development of new therapeutic strategies to arrest glioma invasion.
|
10506168 |
1999 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Furthermore, CCR7 was shown to mediate TGF-β1-induced glioma cancer cell migration by activating matrix metalloproteinase 2 (MMP2)/9.
|
28817313 |
2017 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
LHGDN |
Furthermore, key components (i.e., uPAR, uPA, and pro-MMP-2) were contributed principally by astrocytes, whereas the U251N glioma cells provided plasminogen.
|
12764090 |
2003 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, MALAT1-mediated tumor suppression in glioma cells may be via reduction of extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) signaling activity and expression of matrix metalloproteinase 2 (MMP2).
|
26938295 |
2016 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, this compound suppressed the expression of matrix metalloproteinase-2, a key effector of glioma cell invasion, regulated by fibulin-3.
|
23660683 |
2013 |
|
Glioma
|
0.300 |
Therapeutic
|
disease |
RGD |
Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression.
|
19292920 |
2009 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Here, we attempt to investigate the exact molecular mechanism of how MMP-2 depletion leads to apoptosis in glioma xenograft cell lines.
|
21573233 |
2011 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
IGFBP2 promotes vasculogenic mimicry formation via regulating CD144 and MMP2 expression in glioma.
|
30368528 |
2019 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Imbalance of TIMP-2/MMP-2 was observed using immunoprecipitation analysis in a glioma cell line.
|
10895974 |
2000 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our data demonstrate that Diaph1 is highly expressed in human glioma, plays a significant role in glioma cell migration, and can influence the expression and activity of MMP2 and MMP9 indirectly in human glioma cell lines U87 and U251.
|
29035824 |
2017 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, our data suggest that SERPINB1 negatively regulates glioma cell migration and invasion probably by abrogating the expression of MMP-2 and the activation of FAK.
|
24968089 |
2015 |
|
Glioma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In contrast, enhanced expression of sFRPs inhibits the motility of glioma cells in vitro. sFRP-mediated effects on glioma cells are accompanied by decreased expression and activity of matrix metalloproteinase-2 (MMP-2) and decreased tyrosine phosphorylation of beta-catenin.
|
10980594 |
2000 |
|
Glioma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In spheroid and Boyden chamber migration assays, inhibition of MMP-2 activity using a specific MMP-2 inhibitor and blocking of integrin alpha(v)beta(3) abrogated glioma cell migration stimulated by TGF-beta2.
|
19033423 |
2009 |