|
Craniosynostosis
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
Upregulation of Nell-1 has been associated with craniosynostosis (CS) in humans, and validated in a mouse transgenic Nell-1 overexpression model.
|
31582804 |
2020 |
|
Craniosynostosis
|
0.560 |
Biomarker
|
disease |
BEFREE |
The role of NELL-1, a growth factor associated with craniosynostosis, in promoting bone regeneration.
|
20647499 |
2010 |
|
Craniosynostosis
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
We previously reported the upregulation of NELL-1 in human craniosynostosis and the overexpression of Nell-1 in transgenic animals that induced premature suture closure associated with increased osteoblast differentiation.
|
17042739 |
2007 |
|
Craniosynostosis
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
In summary, Nell-1 overexpression induced calvarial overgrowth resulting in premature suture closure in a rodent model.
|
12235118 |
2002 |
|
Craniosynostosis
|
0.560 |
AlteredExpression
|
disease |
BEFREE |
The loss of the Nell1 function leads to skeletal defects in the cranial vault and vertebral column, and overexpression of Nell1 causes craniosynostosis in mice.
|
27662520 |
2017 |
|
Craniosynostosis
|
0.560 |
Biomarker
|
disease |
BEFREE |
We investigated the therapeutic effects of a craniosynostosis-associated molecule, NEL-like molecule-1 (NELL1; NEL [a protein strongly expressed in neural tissue encoding the epidermal growth factor-like domain]), on osteolysis induced by polyethylene (PE)-particle debris.
|
22404332 |
2012 |
|
Synostotic Anterior Plagiocephaly
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Human NELL-1 expressed in unilateral coronal synostosis.
|
9893069 |
1999 |
|
Synostotic Anterior Plagiocephaly
|
0.320 |
Biomarker
|
disease |
BEFREE |
NELL-1 is a secreted protein that was originally found to be upregulated in pathologically fusing and fused sutures in non-syndromic unilateral coronal synostosis patients.
|
29388706 |
2018 |
|
Scaphycephaly
|
0.310 |
Biomarker
|
disease |
BEFREE |
In the current study, cultured calvarial explants isolated from Nell-1 transgenic newborn mice (with mild sagittal synostosis) demonstrated continuous bone growth and overlapping sagittal sutures.
|
16936265 |
2006 |
|
Adenocarcinoma Of Esophagus
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
The nel-like1 (NELL1) gene maps to chromosome 11p15, which frequently undergoes loss of heterozygosity in esophageal adenocarcinoma (EAC).
|
17452981 |
2007 |
|
Major Depressive Disorder
|
0.310 |
Biomarker
|
disease |
BEFREE |
Therefore, this postmortem study identifies GC1, GRINA, and NRP-1 as novel factors associated with MDD; however, future studies will be needed to address the significance of these genes in the pathophysiology of depression and antidepressant activity.
|
23261523 |
2013 |
|
Leukemia, Myelocytic, Acute
|
0.120 |
AlteredExpression
|
disease |
BEFREE |
NRP-1 was expressed in 80% and 95% of ALL and AML respectively with levels higher in patients than controls and in ALL than AML patients.
|
21978468 |
2012 |
|
Leukemia, Myelocytic, Acute
|
0.120 |
Biomarker
|
disease |
BEFREE |
NRP-1 was revealed to be an independent risk factor for OS in AML (P = 0.003).
|
24737589 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this system, anti‑NRP‑1‑mAb located tTF to the tumor vascular endothelial cell surface and induced vascular embolization.
|
31432158 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Thus, CpG ODN1826 can significantly inhibit tumor growth in a rat model, the mechanism of which may be related to inhibition of the expression of VEGF-C and NRP-1, which have an inhibitory effect on angiogenesis.
|
26345913 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, tumor-penetrating CRGDK peptide-functionalized TPGS<sub>2k</sub> specifically bound to the Nrp-1 receptor to facilitate higher cell uptake of polymeric micelles by tumor cells.
|
29859925 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Gene expression profiling by cDNA microarray revealed a set of up-regulated genes (hvegf-A165, cyclin b1, cdc2, egfr, mmp9, nrp-1, and kdr) in VEGF tumors compared with wild-type lung tissues.
|
25912305 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor xenografts model was used to evaluate the effect of NRP-1 on the tumor growth.
|
31114235 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NRP-1 depletion suppressed tumor growth and liver metastasis and miR-141 mimics inhibited the growth of established tumors in mice.
|
31572065 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Anti-NRP-1 mAb could guide tTF to the surface of tumor vascular endothelial cells and lead to subsequent vascular embolization.
|
30807552 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
New peptide MY1340 revert the inhibition effect of VEGF on dendritic cells differentiation and maturation via blocking VEGF-NRP-1 axis and inhibit tumor growth in vivo.
|
29730556 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our study indicated that the novel transcript Nell-1-ΔE, but not full-length Nell-1, might be a candidate tumor suppressor factor for basic research and clinical practice.
|
29388706 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The cellular transmembrane receptor Neuropilin-1(NRP-1) is overexpressed in tumour tissue and endothelial cells of tumour vessels, whereas it has limited expression in normal tissues.
|
30628471 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In an attempt to elucidate the relationship between biomarkers of tumor hypoxia, glycolysis and angiogenesis, we tested the hypothesis that intratumoral gene expression of the hypoxia response (hypoxia inducible factor [HIF1 alpha and 2 alpha]), glycolysis (lactate dehydrogenase A [LDHA]), glucose metabolism (glucose transporter-1 [Glut-1]) and genes involved in angiogenesis (i.e., VEGFA, VEGFR1-3, and neuropilin [NRP]1) are upregulated in metastatic colorectal cancer (mCRC) patients with high serum lactate dehydrogenase (LDH).
|
18086000 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Widespread expression of NRP-1 in normal tissues may affect anti-NRP-1 antibody tumor uptake.
|
31692439 |
2019 |