|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, for the first time, we demonstrated the emerging role of neural EGFL like 1 (NELL-1) in arthritis pathogenesis by showing that Nell-1-haploinsufficient (Nell-1<sup>+/6R</sup>) mice had accelerated and aggravated osteoarthritis (OA) progression with elevated inflammatory markers in both spontaneous primary OA and chemical-induced secondary OA models.
|
31634652 |
2020 |
|
Cleidocranial Dysplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Global Nell-1 inactivation in mice by N-ethyl-N-nitrosourea (ENU) mutagenesis results in neonatal lethality with skeletal abnormalities including cleidocranial dysplasia (CCD)-like calvarial bone defects.
|
31582804 |
2020 |
|
Hydrocephalus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nell-1 may also be critically involved in regulating cerebrospinal fluid homeostasis and in the pathogenesis of postnatal hydrocephalus.
|
31582804 |
2020 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, for the first time, we demonstrated the emerging role of neural EGFL like 1 (NELL-1) in arthritis pathogenesis by showing that Nell-1-haploinsufficient (Nell-1<sup>+/6R</sup>) mice had accelerated and aggravated osteoarthritis (OA) progression with elevated inflammatory markers in both spontaneous primary OA and chemical-induced secondary OA models.
|
31634652 |
2020 |
|
Abnormality of the skeletal system
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Global Nell-1 inactivation in mice by N-ethyl-N-nitrosourea (ENU) mutagenesis results in neonatal lethality with skeletal abnormalities including cleidocranial dysplasia (CCD)-like calvarial bone defects.
|
31582804 |
2020 |
|
Malignant neoplasm of endometrium
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of NRP-1 and NRP-2 in Endometrial Cancer.
|
30806307 |
2019 |
|
Malignant tumor of cervix
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nrp-1 plays critical roles in hypoxic TME-induced activation and pro-tumoral effects of TAMs in cervical cancer.
|
30362630 |
2019 |
|
Liver Cirrhosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
NRP-1 promotes angiogenesis by upregulating the expression and activation of VEGFR2 through the PI3K/Akt signalling pathway in liver cirrhosis.
|
31060904 |
2019 |
|
Lupus Nephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
NRP-1 is increased in kidney biopsies of LN.
|
31533337 |
2019 |
|
Lymphoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
NRP-1 exhibited higher expression in lymphomas, and it was positively expressed in EBV-positive lymphomas.
|
31282408 |
2019 |
|
Ankylosing spondylitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
AS patients with PA showed an earlier age of disease onset (p=0.021), longer disease duration (p=0.020) and longer duration of AS symptoms from onset (p=0.034) than AS patients without PA. We found significant associations with the presence of PA at disease onset in 14 SNPs located in 10 genes: HLA-DQB2 (rs2857210 and rs9276615), HLA-DOB (rs2857151, rs2621332 and rs1383261), JAK2 (rs7857730), IL-23R (rs11209008 and rs10489630), CYP1B1 (rs1056836), NELL1 (rs8176786), KL (rs564481), and MEFV (rs224204), IL-2RB (rs743777) and IL-1A (rs1800587).
|
30299251 |
2019 |
|
Acute leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Consequently, NRP-1/Sema3A signaling may represent a novel target for the treatment of acute leukemia and should be further studied.Anat Rec, 302:1127-1135, 2019.
|
30378769 |
2019 |
|
Cervical Intraepithelial Neoplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
<b>Results:</b> The expression of NRP-1 was upregulated in the tumor tissues compared with the CIN and normal tissues (<i>P</i><0.0001).
|
31114235 |
2019 |
|
Peripheral arthritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
AS patients with PA showed an earlier age of disease onset (p=0.021), longer disease duration (p=0.020) and longer duration of AS symptoms from onset (p=0.034) than AS patients without PA. We found significant associations with the presence of PA at disease onset in 14 SNPs located in 10 genes: HLA-DQB2 (rs2857210 and rs9276615), HLA-DOB (rs2857151, rs2621332 and rs1383261), JAK2 (rs7857730), IL-23R (rs11209008 and rs10489630), CYP1B1 (rs1056836), NELL1 (rs8176786), KL (rs564481), and MEFV (rs224204), IL-2RB (rs743777) and IL-1A (rs1800587).
|
30299251 |
2019 |
|
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggest that NELL1 induces lung cancer stem‑like cell differentiation, which provides a new potential therapeutic target for cancer stem cells.
|
30628703 |
2019 |
|
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nrp-1 plays critical roles in hypoxic TME-induced activation and pro-tumoral effects of TAMs in cervical cancer.
|
30362630 |
2019 |
|
Immune thrombocytopenic purpura
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study shows for the first time that NRP-1 is involved in the pathogenesis of ITP, THD could induce response in ITP patients by upregulating NRP-1 expression and restoring the proportion of Tregs and Bregs.
|
31030100 |
2019 |
|
Endometrial Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of NRP-1 and NRP-2 in Endometrial Cancer.
|
30806307 |
2019 |
|
Secondary malignant neoplasm of liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
NRP-1 depletion suppressed tumor growth and liver metastasis and miR-141 mimics inhibited the growth of established tumors in mice.
|
31572065 |
2019 |
|
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggest that NELL1 induces lung cancer stem‑like cell differentiation, which provides a new potential therapeutic target for cancer stem cells.
|
30628703 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nrp-1 and M2-like TAMs were related to the malignant properties of cervical cancer, such as the FIGO stage and lymph node metastasis.
|
30362630 |
2019 |
|
Primary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggest that NELL1 induces lung cancer stem‑like cell differentiation, which provides a new potential therapeutic target for cancer stem cells.
|
30628703 |
2019 |
|
cervical cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nrp-1 plays critical roles in hypoxic TME-induced activation and pro-tumoral effects of TAMs in cervical cancer.
|
30362630 |
2019 |
|
Squamous cell carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Multifactor dimensionality reduction analysis showed that the interactions among HPV and NELL1 variant rs1670661 with age and gender augmented the risk of both non-tobacco- and tobacco-related oral squamous cell carcinoma, respectively.
|
30091681 |
2018 |
|
Encephalomyelitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, BSYSC treatment increased the expressions of LIF, LIFR and Nkx6.2 and reduced Sema3A and NRP-1 in EAE mice on 40 dpi.
|
29428242 |
2018 |