NELL1, neural EGFL like 1, 4745

N. diseases: 122; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.300 GeneticVariation disease UNIPROT
CUI: C2931150
Disease: Synostotic Anterior Plagiocephaly
Synostotic Anterior Plagiocephaly 		0.320 AlteredExpression disease BEFREE Human NELL-1 expressed in unilateral coronal synostosis. 9893069 1999
CUI: C0332877
Disease: Congenital premature fusion
Congenital premature fusion 		0.010 AlteredExpression disease BEFREE In conclusion, our data suggest that the NELL-1 gene is preferentially expressed in cranial intramembranous bone and neural tissue (both of neural crest cell origin) and is up-regulated during unilateral premature closure of the coronal suture. 9893069 1999
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.020 AlteredExpression disease BEFREE NELL1 and NELL2 were predominantly expressed in neuroblastoma cell lines and little expressed in glioblastoma cell lines. 11803583 2001
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.020 AlteredExpression disease BEFREE NELL1 and NELL2 were predominantly expressed in neuroblastoma cell lines and little expressed in glioblastoma cell lines. 11803583 2001
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.020 AlteredExpression disease BEFREE NELL1 and NELL2 were predominantly expressed in neuroblastoma cell lines and little expressed in glioblastoma cell lines. 11803583 2001
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.020 AlteredExpression disease BEFREE NELL1 and NELL2 were predominantly expressed in neuroblastoma cell lines and little expressed in glioblastoma cell lines. 11803583 2001
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.010 AlteredExpression disease BEFREE NELL1 and NELL2 were predominantly expressed in neuroblastoma cell lines and little expressed in glioblastoma cell lines. 11803583 2001
CUI: C0206715
Disease: Neoplasms, Neuroepithelial
Neoplasms, Neuroepithelial 		0.010 AlteredExpression group BEFREE Brain specific human genes, NELL1 and NELL2, are predominantly expressed in neuroblastoma and other embryonal neuroepithelial tumors. 11803583 2001
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.010 AlteredExpression disease BEFREE NELL1 and NELL2 were predominantly expressed in neuroblastoma cell lines and little expressed in glioblastoma cell lines. 11803583 2001
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.010 AlteredExpression disease BEFREE NELL1 and NELL2 were predominantly expressed in neuroblastoma cell lines and little expressed in glioblastoma cell lines. 11803583 2001
CUI: C0010278
Disease: Craniosynostosis
Craniosynostosis 		0.560 Biomarker disease RGD In summary, Nell-1 overexpression induced calvarial overgrowth resulting in premature suture closure in a rodent model. 12235118 2002
CUI: C0010278
Disease: Craniosynostosis
Craniosynostosis 		0.560 AlteredExpression disease BEFREE In summary, Nell-1 overexpression induced calvarial overgrowth resulting in premature suture closure in a rodent model. 12235118 2002
CUI: C0010278
Disease: Craniosynostosis
Craniosynostosis 		0.560 AlteredExpression disease LHGDN In summary, Nell-1 overexpression induced calvarial overgrowth resulting in premature suture closure in a rodent model. 12235118 2002
CUI: C0039093
Disease: Congenital abnormal Synostosis
Congenital abnormal Synostosis 		0.010 Biomarker disease BEFREE Nell-1 transgenic animals exhibited CS-like phenotypes that ranged from simple to compound synostoses. 12235118 2002
CUI: C0010278
Disease: Craniosynostosis
Craniosynostosis 		0.560 Biomarker disease CTD_human Nell-1 overexpression induced calvarial overgrowth and resulted in premature suture closure in a rodent model. 14672347 2003
CUI: C2931150
Disease: Synostotic Anterior Plagiocephaly
Synostotic Anterior Plagiocephaly 		0.320 Biomarker disease CTD_human Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development. 14672347 2003
CUI: C0265534
Disease: Scaphycephaly
Scaphycephaly 		0.310 Biomarker disease CTD_human Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development. 14672347 2003
CUI: C0030044
Disease: Acrocephaly
Acrocephaly 		0.300 Biomarker disease CTD_human Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development. 14672347 2003
CUI: C0221356
Disease: Brachycephaly
Brachycephaly 		0.300 Biomarker disease CTD_human Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development. 14672347 2003
CUI: C0265535
Disease: Trigonocephaly
Trigonocephaly 		0.300 Biomarker disease CTD_human Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development. 14672347 2003
CUI: C1833340
Disease: Synostotic Posterior Plagiocephaly
Synostotic Posterior Plagiocephaly 		0.300 Biomarker disease CTD_human Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development. 14672347 2003
CUI: C1860819
Disease: Metopic synostosis
Metopic synostosis 		0.300 Biomarker disease CTD_human Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development. 14672347 2003
CUI: C4551902
Disease: Craniosynostosis, Type 1
Craniosynostosis, Type 1 		0.300 Biomarker disease CTD_human Overexpression of Nell-1, a craniosynostosis-associated gene, induces apoptosis in osteoblasts during craniofacial development. 14672347 2003
CUI: C0338106
Disease: Adenocarcinoma of colon
Adenocarcinoma of colon 		0.010 AlteredExpression disease BEFREE NRP-1 was expressed in 20 of 20 human colon adenocarcinoma specimens but not in the adjacent nonmalignant colonic mucosa. 15161648 2004