|
Cerebrovascular accident
|
0.080 |
GeneticVariation
|
group |
BEFREE |
Two intergenic single-nucleotide polymorphisms on chromosome 12p13 and within 11 kb of the gene NINJ2 were associated with stroke (P<5x10(-8)).
|
19369658 |
2009 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>In vivo</i>, NINJ2-silenced or NINJ2-knockout CRC xenografts grew significantly slower than the control xenografts.
|
31597121 |
2019 |
|
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Contrarily, ectopic overexpression of Ninj2 promoted glioma cell progression <i>in vitro</i>.
|
31794427 |
2019 |
|
Multiple Sclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we genotyped two NINJ2 single nucleotide polymorphisms (SNPs) namely rs11833579 and rs3809263 in a population of Iranian patients with MS as well as healthy individuals.
|
31292852 |
2019 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In established and primary human glioma cells, Ninj2 shRNA or knockout (by CRISPR/Cas9 gene editing) potently inhibited cell survival, growth, proliferation, cell migration and invasion, while inducing apoptosis activation.
|
31794427 |
2019 |
|
Multiple Sclerosis, Relapsing-Remitting
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Two of the genes that showed both methylation and expression differences, NINJ2 and SLFN12, have not previously been implicated in MS. SLFN12 is a particularly compelling target of further research, as this gene is known to be down-regulated during T cell activation and up-regulated by type I interferons (IFNs), which are used to treat MS.
|
30379917 |
2018 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, our study suggests that ninjurin2 is a novel regulator of endothelia inflammation and activation through TLR4 signaling pathways, and these data provided new insights into the mechanisms between NINJ2 and atherosclerosis.
|
28431986 |
2017 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, our study suggests that ninjurin2 is a novel regulator of endothelia inflammation and activation through TLR4 signaling pathways, and these data provided new insights into the mechanisms between NINJ2 and atherosclerosis.
|
28431986 |
2017 |
|
Herpes NOS
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The following nerve injury testing was performed on all of the patients including: the numerical rating scale (NRS) test, quantitative sensory testing (QST), and the investigation of serum NINJ2 levels on the 7th day of AHN; in addition, all of the patients repeated all of the items at 6 months after herpes.
|
29069724 |
2017 |
|
Borderline Personality Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Bead chip technology and quantitative bisulfite pyrosequencing showed a significantly increased methylation at CpG sites of APBA2 (1.1 fold) and APBA3 (1.1 fold), KCNQ1 (1.5 fold), MCF2 (1.1 fold) and NINJ2 (1.2 fold) in BPD patients.
|
24367640 |
2013 |
|
Alzheimer's Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The global test for the association between NINJ2 haplotypes and AD was significant (p = 0.03).
|
21674003 |
2011 |
|
Presenile dementia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Five common (frequency >5%) haplotype-tagging single nucleotide polymorphisms (htSNPs) in NINJ2 were genotyped to test for the association between sequence variants of NINJ2 and dementia risk, and how vascular risk factors modify this association.
|
21674003 |
2011 |
|
Dementia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Five common (frequency >5%) haplotype-tagging single nucleotide polymorphisms (htSNPs) in NINJ2 were genotyped to test for the association between sequence variants of NINJ2 and dementia risk, and how vascular risk factors modify this association.
|
21674003 |
2011 |