|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
While genetic polymorphisms affect iNOS expression, it is not known whether iNOS gene polymorphisms affect the susceptibility to hypertension and the responses to antihypertensive therapy.
|
23266817 |
2013 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this study, we assessed whether SNPs within NOS2 gene were associated with severity of sepsis in Chinese populations.
|
23192595 |
2013 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
SNPs (N = 121) belonging to NOS1, NOS2 and NOS3 genes were genotyped in 1277 adults from the French Epidemiological study on the Genetics and Environment of Asthma (EGEA).
|
22590587 |
2012 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate comprehensively the association between single nucleotide polymorphisms (SNPs) in all three NOS genes and FENO in an adult population, and to assess whether such associations are modified by asthma or atopy.
|
22368302 |
2012 |
|
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Severe asthma was associated with the highest levels of iNOS protein and mRNA, although the index of iNOS mRNA to arginase2 mRNA most strongly differentiated severe from milder asthma.
|
22092728 |
2012 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
RGD |
Phosphatidylinositol 3-kinase inhibitor suppresses inducible nitric oxide synthase expression in bronchiole epithelial cells in asthmatic rats.
|
21847581 |
2012 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In addition, a significant association was found when the (CCTTT) repetition of the NOS2A gene was present more than 14 times in patients with NP and asthma (P = .034), in patients with polyposis and intolerance to nonsteroidal anti-inflammatory drugs (P = .009), and in patients with the aspirin triad (P = .005).
|
23101307 |
2012 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Animal studies have allowed important insights into the role of the nitric oxide synthase (NOS) enzymes in atherosclerosis and hypertension, as well as in stroke.
|
22153699 |
2012 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The association of a NOS2A promoter haplotype with FeNO varied significantly by rs3742879 genotypes and by asthma.
|
21039601 |
2011 |
|
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
BEFREE |
We have recently reported that inducible nitric oxide synthase (NOS2) is a strong predictor of survival in patients with estrogen receptor negative [ER(-)] breast cancer, and that NOS2 expression is correlated with a basal-like phenotype.
|
21893353 |
2011 |
|
Malignant neoplasm of breast
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Evaluation of a multi-functional nanocarrier for targeted breast cancer iNOS gene therapy.
|
21134429 |
2011 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Inducible NOS inhibition reverses tobacco-smoke-induced emphysema and pulmonary hypertension in mice.
|
22000010 |
2011 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Association between the NOS2A region and asthma or lung function growth was tested using genetic block-specific principal component and haplotype analyses.
|
19996333 |
2010 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
CTD_human |
We found that administration of nor-NOHA significantly decreased airway hyperreactivity and eosinophilic airway inflammation in ovalbumin-exposed C57BL/6 mice, but these parameters were unchanged in ovalbumin-exposed NOS2-/- mice.
|
19800904 |
2010 |
|
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
To investigate whether NOS2 levels influence survival of breast cancer patients, we examined NOS2 expression and its association with tumor markers and survival in 248 breast tumors.
|
20978357 |
2010 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
CTD_human |
Essential role of nitric oxide in sepsis-induced impairment of endothelium-derived hyperpolarizing factor-mediated relaxation in rat pulmonary artery.
|
20035746 |
2010 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The objective of this project was to evaluate the association of NOS polymorphisms and environmental exposures with FeNO levels among children with asthma.
|
19603529 |
2009 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The aim of this study was to investigate the association between variant in the human iNOS gene and susceptibility to hypertension in Chinese Han.
|
19402223 |
2009 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
(CCTTT)n polymorphism of NOS2A in nasal polyposis and asthma: a case-control study.
|
18714530 |
2008 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
(CCTTT)n polymorphism of NOS2A in nasal polyposis and asthma: a case-control study.
|
18714530 |
2008 |
|
Asthma
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
Nasal mucosal expression of nitric oxide synthases in patients with allergic rhinitis and its relation to asthma.
|
18254476 |
2008 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Arginases have been proposed to contribute to asthma pathogenesis by limiting the arginine substrate available to NOS enzymes, but expression of any of these enzymes has not been extensively studied in primary human cells.
|
18384429 |
2008 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Serum neopterin, nitric oxide, inducible nitric oxide synthase and tumor necrosis factor-alpha levels in patients with ischemic heart disease.
|
18605955 |
2008 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Physician-diagnosed asthma and acute chest syndrome: associations with NOS polymorphisms.
|
17351927 |
2007 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To investigate the association of inducible nitric oxide synthases (iNOS) gene repeat polymorphisms with asthma.
|
17189532 |
2007 |