|
Sepsis
|
0.600 |
Biomarker
|
disease |
CTD_human |
Down-regulation of CXCR2 on neutrophils in severe sepsis is mediated by inducible nitric oxide synthase-derived nitric oxide.
|
17138957 |
2007 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
RGD |
Effects of inducible nitric oxide synthase inhibitors on asthma depending on administration schedule.
|
16540403 |
2006 |
|
Asthma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Asthma is associated with airway hyperresponsiveness and enhanced T-cell number/activity on one hand and increased levels of exhaled nitric oxide (NO) with expression of inducible NO synthase (iNOS) on the other hand.
|
16597326 |
2006 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings do not support NOS2 to be a major candidate gene for asthma or IgE-mediated allergic diseases in Chinese children.
|
16703578 |
2006 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that inducible NOS can play a role in atopic disorders, and several polymorphisms in its gene may be important for asthma protection or susceptibility.
|
17177683 |
2006 |
|
Malignant neoplasm of breast
|
0.600 |
Biomarker
|
disease |
CTD_human |
Nitric oxide produced by inducible nitric oxide synthase is associated with mammary tumorigenesis in irradiated rats.
|
15631943 |
2005 |
|
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
To examine these results in further detail, the effect of progesterone (Pg) and 17beta-oestradiol (E2) on NOSII expression was analysed in the human breast cancer cell line MCF-7.
|
15778733 |
2005 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
RGD |
Overexpression of inducible nitric oxide synthase in the kidney of the spontaneously hypertensive rat.
|
15773227 |
2005 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Relationship of eNOS gene variants to diseases that have in common an endothelial cell dysfunction.
|
15784171 |
2005 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Little is known about transcriptional regulation of the human iNOS gene in vivo under basal conditions or in sepsis.
|
15507544 |
2005 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
RGD |
Suppression of hepatic cytochrome p450-mediated drug metabolism during the late stage of sepsis in rats.
|
15665729 |
2005 |
|
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Some studies showed a positive correlation between the level of NOS protein and progression of malignancy in human breast cancer.
|
15375508 |
2004 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
For instance, NO potentiates the hepatic oxidative injury in warm ischemia/reperfusion, while iNOS expression protects against hepatic apoptotic cell death seen in models of sepsis and hepatitis.
|
14527083 |
2003 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results suggest that TXA2 has a protective role against the development of vascular hyporesponsiveness via its inhibitory action on the iNOS-NO system under pathological conditions such as sepsis.
|
14557367 |
2003 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We tested whether this potentially functional allele in the NOS2 gene influences the development of atopy and asthma.
|
11692109 |
2001 |
|
Asthma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Neither NOS2 nor NOS3 variants showed any association with asthma nor IgE levels.
|
10673365 |
2000 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We therefore tested NOS2A markers for association and linkage with hypertension in affected Australian Anglo-Caucasians.
|
10205225 |
1999 |
|
Malignant neoplasm of breast
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Finally, we did not find the up-regulation of NOS isoforms during NSCLC progression that has been suggested for gynaecological and breast cancers.
|
9683299 |
1998 |
|
Asthma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our studies describe for the first time the presence of iNOS on eosinophil and a putative new role for this cell in inflammatory states such as asthma and parasitic disease.
|
8993004 |
1997 |
|
Malignant neoplasm of breast
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.570 |
AlteredExpression
|
disease |
BEFREE |
Here we studied the possible role of these gasotransmitters in both murine and human type 2 diabetes (T2D) by mapping the expression pattern of neural nitric oxide synthase (nNOS), inducible NOS (iNOS), constitutive heme oxygenase (HO-2), and inducible HO (HO-1) in isolated pancreatic islets.
|
31607476 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.570 |
GeneticVariation
|
disease |
BEFREE |
The impact of NOS2 gene polymorphism was investigated on the susceptibility of T2D in a sample of Iranian population (Southeastern of Iran).
|
30581791 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.570 |
AlteredExpression
|
disease |
BEFREE |
This pilot study analyzed whether a 3-month endurance training can affect iNOS protein and NO metabolite levels in the vastus lateralis muscle of insulin-independent T2DM men, thereby affecting the patients` glycemic control.
|
27782779 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.570 |
GeneticVariation
|
disease |
BEFREE |
The allele-C and genotype-TC of NOS2 rs2779248, allele-A and genotype-GA of NOS2 rs1137933 and genotype-AA of NOS3 rs3918188 genetic polymorphisms might be the risk factors for increasing the susceptibility to T2DM.
|
27192959 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.570 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations in the NOS2 gene promoter and TLR4 coding sequence may lead to deleterious and protective effects, respectively, arising from altered function of the innate immune system in patients with T2DM.
|
19395279 |
2010 |