NOTCH4, notch receptor 4, 4855

N. diseases: 150; N. variants: 58
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE No statistical association between the two single nucleotide polymorphisms of the Notch4 gene and schizophrenia was observed in our Japanese samples. 16538185 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker disease BEFREE The haplotype -1725G/-25T at the NOTCH4 locus, which results from SNPs of NOTCH4 that are in LD, may increase susceptibility to schizophrenia in AAs. 14732589 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker disease BEFREE Our results would indicate that a significant role for the Notch4 gene in schizophrenia can be ruled out in the Han Chinese. 11803454 2002
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE Our data indicate that NOTCH4 polymorphism can influence clinical symptoms in Slovenian patients with schizophrenia. 25529856 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease LHGDN The NOTCH4 T-25C polymorphism has an important effect on the age of onset in schizophrenia and thus may be related to an early pathogenesis of schizophrenia in young patients. 12782960 2003
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE The present study found that the NOTCH4 gene does not confer susceptibility to schizophrenia and schizoaffective disorders, at least in Japanese subjects, in contrast to the findings in British subjects. 11239712 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE Our data suggest a lack of association between the NOTCH4 gene triplet repeat polymorphism and schizophrenia in Japanese individuals. 11407996 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease GWASDB Common variants at VRK2 and TCF4 conferring risk of schizophrenia. 21791550 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease LHGDN Although these associations became insignificant after Bonferroni correction, the findings might provide support for the association of the TNXB locus or its adjacent region of the NOTCH4 locus with schizophrenia. 17192952 2007
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE Methylation analysis of the NOTCH4 -25 C/T polymorphism in schizophrenia. 21085055 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE Interestingly, a significant association was found for rs424232 (χ² = 9.404, P = 0.002, OR = 0.69, 95 % CI 0.54-0.88), which is a tag SNP for the DRB1*1303 allele and located near to the NOTCH4 gene that is a schizophrenia susceptibility locus confirmed by GWA studies. 23053058 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE Since more consistent and robust associations with schizophrenia risk have been observed for haplotypes of these polymorphisms [especially those containing SNP2 and (CTG)n], additional large family-based or genomic-controlled studies would be helpful for definitively specifying the role of NOTCH4 haplotypes in risk for schizophrenia. 15653273 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE Our results suggest that an interaction between COMT and NOTCH4 genotypes may predict the treatment response to typical neuroleptics in patients with schizophrenia. 15115916 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE Our study failed to replicate the significant association between the NOTCH4 gene rs3131296 polymorphism and the risk for SZ. 25142293 2014
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE In a previous study, we found that rs520692, a single nucleotide polymorphism (SNP) at the NOTCH4 locus, was associated with schizophrenia in a Chinese population. 16894623 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker disease LHGDN Our results suggested NOTCH4 or neighboring gene might be a common susceptible gene for SP and MD in the pedigrees studied. 16378929 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease GWASCAT Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. 28540026 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE The finding of the present study could not support the original findings that the NOTCH4 gene itself is associated with susceptibility to schizophrenia. 15009827 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 AlteredExpression disease BEFREE β2 microglobulin, HLA-A and Notch4 were all expressed in a pattern where inflammatory illness was associated with increased expression in controls but not in subjects with schizophrenia. 23395714 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease GWASDB A comprehensive family-based replication study of schizophrenia genes. 23894747 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE These analyses suggest that the NOTCH4 polymorphisms most strongly associated with schizophrenia exert their effects on susceptibility by altering the efficiency and/or alternative splicing of Notch4 transcripts. 22488909 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE Variants of NOTCH4 are associated with schizophrenia, thus DLL4 is both a functional as well as a positional candidate for schizophrenia. 15820317 2005
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 Biomarker disease BEFREE In conclusion, the present study provided no clear evidence for an association between the NOTCH4 gene and schizophrenia in the Japanese population. 15211628 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 AlteredExpression disease BEFREE The authors investigated the NOTCH4 gene expression in individuals with bipolar disorder and schizophrenia relative to healthy comparison subjects and identified putative expression quantitative trait loci in and around the NOTCH4 gene. 23212060 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.500 GeneticVariation disease BEFREE Our results suggest that NOTCH4 is unlikely to play a major role in the genetic predisposition to schizophrenia in the German or the Palestinian-Arab population. 16969274 2006