|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
No statistical association between the two single nucleotide polymorphisms of the Notch4 gene and schizophrenia was observed in our Japanese samples.
|
16538185 |
2006 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data indicate that NOTCH4 polymorphism can influence clinical symptoms in Slovenian patients with schizophrenia.
|
25529856 |
2015 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
The NOTCH4 T-25C polymorphism has an important effect on the age of onset in schizophrenia and thus may be related to an early pathogenesis of schizophrenia in young patients.
|
12782960 |
2003 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The present study found that the NOTCH4 gene does not confer susceptibility to schizophrenia and schizoaffective disorders, at least in Japanese subjects, in contrast to the findings in British subjects.
|
11239712 |
2001 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest a lack of association between the NOTCH4 gene triplet repeat polymorphism and schizophrenia in Japanese individuals.
|
11407996 |
2001 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Common variants at VRK2 and TCF4 conferring risk of schizophrenia.
|
21791550 |
2011 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
Although these associations became insignificant after Bonferroni correction, the findings might provide support for the association of the TNXB locus or its adjacent region of the NOTCH4 locus with schizophrenia.
|
17192952 |
2007 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Methylation analysis of the NOTCH4 -25 C/T polymorphism in schizophrenia.
|
21085055 |
2011 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, a significant association was found for rs424232 (χ² = 9.404, P = 0.002, OR = 0.69, 95 % CI 0.54-0.88), which is a tag SNP for the DRB1*1303 allele and located near to the NOTCH4 gene that is a schizophrenia susceptibility locus confirmed by GWA studies.
|
23053058 |
2013 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Since more consistent and robust associations with schizophrenia risk have been observed for haplotypes of these polymorphisms [especially those containing SNP2 and (CTG)n], additional large family-based or genomic-controlled studies would be helpful for definitively specifying the role of NOTCH4 haplotypes in risk for schizophrenia.
|
15653273 |
2005 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that an interaction between COMT and NOTCH4 genotypes may predict the treatment response to typical neuroleptics in patients with schizophrenia.
|
15115916 |
2004 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our study failed to replicate the significant association between the NOTCH4 gene rs3131296 polymorphism and the risk for SZ.
|
25142293 |
2014 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In a previous study, we found that rs520692, a single nucleotide polymorphism (SNP) at the NOTCH4 locus, was associated with schizophrenia in a Chinese population.
|
16894623 |
2006 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.
|
28540026 |
2017 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The finding of the present study could not support the original findings that the NOTCH4 gene itself is associated with susceptibility to schizophrenia.
|
15009827 |
2004 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
A comprehensive family-based replication study of schizophrenia genes.
|
23894747 |
2013 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These analyses suggest that the NOTCH4 polymorphisms most strongly associated with schizophrenia exert their effects on susceptibility by altering the efficiency and/or alternative splicing of Notch4 transcripts.
|
22488909 |
2012 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Variants of NOTCH4 are associated with schizophrenia, thus DLL4 is both a functional as well as a positional candidate for schizophrenia.
|
15820317 |
2005 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that NOTCH4 is unlikely to play a major role in the genetic predisposition to schizophrenia in the German or the Palestinian-Arab population.
|
16969274 |
2006 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A major consortium study have recently linked BD to hundreds of variations with stronger associations in the MHC region, such as the rs3130297 SNP, located in the NOTCH4 gene, with an additional overlapping association with schizophrenia.
|
21987052 |
2012 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association analysis of NOTCH 4 polymorphisms with schizophrenia among two independent family based samples.
|
15389759 |
2004 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The rs2071287 and rs204993 polymorphisms of the NOTCH4 gene were analyzed in 443 patients with SCZ and 628 controls of Han Chinese descent.
|
26605328 |
2015 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.
|
30285260 |
2019 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Although these associations became insignificant after Bonferroni correction, the findings might provide support for the association of the TNXB locus or its adjacent region of the NOTCH4 locus with schizophrenia.
|
17192952 |
2007 |
|
Schizophrenia
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Because the TNXB gene is less than 100 kb away from the NOTCH4 locus that was also reported to be associated with schizophrenia, allelic and locus heterogeneity could be possible reasons for the failure to replicate the TNXB finding.
|
14729256 |
2004 |