NOTCH4, notch receptor 4, 4855

N. diseases: 150; N. variants: 58
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007772
Disease: Intracranial Arteriovenous Malformation
Intracranial Arteriovenous Malformation 		0.200 Biomarker disease MGD
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease PSYGENET β2 microglobulin, HLA-A and Notch4 were all expressed in a pattern where inflammatory illness was associated with increased expression in controls but not in subjects with schizophrenia. 23395714 2013
CUI: C0023418
Disease: leukemia
leukemia 		0.010 Biomarker disease BEFREE 654P/int3- enh/3'-enh vector containing transgenes such as suicide genes might become useful tools for leukemia-specific gene therapy. 14737070 2004
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.010 Biomarker disease BEFREE 654P/int3- enh/3'-enh vector containing transgenes such as suicide genes might become useful tools for leukemia-specific gene therapy. 14737070 2004
CUI: C0002448
Disease: Ameloblastoma
Ameloblastoma 		0.010 AlteredExpression disease BEFREE Ameloblastoma tumor epithelium demonstrated positive expression for Notch1 (n = 5/10), Notch3 (n = 8/10), Notch4 (n = 10/10), Jagged1 (n = 6/10) and Delta1 (n = 5/10), but no reactivity for Notch2 (n = 10/10) and Jagged2 (10/10). 20337864 2010
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.010 Biomarker disease BEFREE Hepatitis B virus X protein activates Notch signaling by its effects on Notch1 and Notch4 in human hepatocellular carcinoma. 26530164 2016
CUI: C0002170
Disease: Alopecia
Alopecia 		0.020 Biomarker disease BEFREE Notch4, a non-HLA gene in the MHC is strongly associated with the most severe form of alopecia areata. 12589427 2003
CUI: C0002171
Disease: Alopecia Areata
Alopecia Areata 		0.020 Biomarker disease BEFREE Notch4, a non-HLA gene in the MHC is strongly associated with the most severe form of alopecia areata. 12589427 2003
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease BEFREE NOTCH4 is not a significant susceptibility gene for schizophrenia when clinical heterogeneity is ignored; however, NOTCH4 may be associated with early-onset schizophrenia or schizophrenia with many negative symptoms, but these findings should be interpreted cautiously. 12873802 2003
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia 		0.010 GeneticVariation phenotype BEFREE Int3/3'-ass/C(-6) --> T was found in both groups in the present study although it was regarded as a pathogenic variant to HTG earlier on. 17560523 2007
CUI: C0010606
Disease: Adenoid Cystic Carcinoma
Adenoid Cystic Carcinoma 		0.020 Biomarker disease BEFREE Notch-4 contributes to the metastasis of salivary adenoid cystic carcinoma. 20596622 2010
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE NOTCH4 inhibition reduced tumour volume and tumourigenicity of mouse xenografts. 24403446 2014
CUI: C3539878
Disease: Triple Negative Breast Neoplasms
Triple Negative Breast Neoplasms 		0.050 Biomarker disease BEFREE NOTCH4 is a new potential therapeutic target for triple-negative breast cancer. 24403446 2014
CUI: C4722518
Disease: Triple-Negative Breast Carcinoma
Triple-Negative Breast Carcinoma 		0.040 Biomarker disease BEFREE NOTCH4 is a new potential therapeutic target for triple-negative breast cancer. 24403446 2014
CUI: C3544321
Disease: Treatment-resistant schizophrenia
Treatment-resistant schizophrenia 		0.310 GeneticVariation disease BEFREE NOTCH4 rs367398 was not statistically significantly associated with the occurrence of treatment-resistant schizophrenia after the correction for multiple testing. 25529856 2015
CUI: C3544321
Disease: Treatment-resistant schizophrenia
Treatment-resistant schizophrenia 		0.310 Biomarker disease PSYGENET NOTCH4 rs367398 was not statistically significantly associated with the occurrence of treatment-resistant schizophrenia after the correction for multiple testing. 25529856 2015
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.400 Biomarker disease BEFREE Notch4 Signaling Confers Susceptibility to TRAIL-Induced Apoptosis in Breast Cancer Cells. 25704336 2015
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 Biomarker disease BEFREE Notch4 Signaling Confers Susceptibility to TRAIL-Induced Apoptosis in Breast Cancer Cells. 25704336 2015
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.020 AlteredExpression disease BEFREE Notch4 mRNA high expression was not found to be significantly correlated to OS for all ovarian cancer patients, serous cancer patients, and endometrioid cancer patients. 26662955 2016
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.020 AlteredExpression disease BEFREE Notch4 mRNA high expression was not found to be significantly correlated to OS for all ovarian cancer patients, serous cancer patients, and endometrioid cancer patients. 26662955 2016
CUI: C4721610
Disease: Carcinoma, Ovarian Epithelial
Carcinoma, Ovarian Epithelial 		0.020 AlteredExpression disease BEFREE Notch4 mRNA high expression was not found to be significantly correlated to OS for all ovarian cancer patients, serous cancer patients, and endometrioid cancer patients. 26662955 2016
CUI: C0334533
Disease: Arteriovenous hemangioma
Arteriovenous hemangioma 		0.010 GeneticVariation disease BEFREE NOTCH4 gene polymorphisms as potential risk factors for brain arteriovenous malformation development and hemorrhagic presentation. 27231971 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.050 AlteredExpression phenotype BEFREE Notch-4 silencing also resulted in decreased cell migration and invasion and affected the expression of EMT markers. 28374086 2017
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.020 AlteredExpression disease BEFREE Notch4 mRNA high expression was significantly correlated with favorite OS, but not PFS and PPS for all ovarian cancer patients. 28415574 2017
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.020 AlteredExpression disease BEFREE Notch4 mRNA high expression was significantly correlated with favorite OS, but not PFS and PPS for all ovarian cancer patients. 28415574 2017