NOTCH4, notch receptor 4, 4855

N. diseases: 150; N. variants: 58
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007772
Disease: Intracranial Arteriovenous Malformation
Intracranial Arteriovenous Malformation 		0.200 Biomarker disease MGD
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Transgenic mouse strains overexpressing the oncogenes transforming growth factor-alpha, neu, int-3, polyoma virus middle T antigen, and simian virus 40 large T antigen have been previously shown to develop spontaneous mammary neoplasia. 8561865 1996
CUI: C0036095
Disease: Salivary Gland Neoplasms
Salivary Gland Neoplasms 		0.010 Biomarker group BEFREE Microsatellite polymorphism of (CTG)n repeat in the signal peptide domain of NOTCH4 was analyzed in Japanese including the patients with salivary gland tumor. 9243759 1997
CUI: C0027404
Disease: Narcolepsy
Narcolepsy 		0.110 GeneticVariation disease BEFREE These results suggest that the (CTG)n repeat polymorphism in NOTCH4 does not primarily determine the susceptibility to narcolepsy. 9458119 1997
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease BEFREE The A-->G substitution in the promoter region and the (CTG)n repeat in exon 1 of NOTCH4 may be candidate sites conferring susceptibility to schizophrenia. 10932176 2000
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.010 AlteredExpression phenotype BEFREE We have assessed four signal transduction pathways to determine which might play additional roles in malignant transformation in concert with activated Notch4. 10980592 2000
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium 		0.010 Biomarker disease BEFREE These results suggest that human Notch4 and/or TAN-1 are involved in the changes of the endometrium during the menstrual cycle, and also in the development of endometrial cancer. 11078798 2000
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.010 Biomarker disease BEFREE These results suggest that human Notch4 and/or TAN-1 are involved in the changes of the endometrium during the menstrual cycle, and also in the development of endometrial cancer. 11078798 2000
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE The present study found that the NOTCH4 gene does not confer susceptibility to schizophrenia and schizoaffective disorders, at least in Japanese subjects, in contrast to the findings in British subjects. 11239712 2001
CUI: C0036337
Disease: Schizoaffective Disorder
Schizoaffective Disorder 		0.010 GeneticVariation disease BEFREE The present study found that the NOTCH4 gene does not confer susceptibility to schizophrenia and schizoaffective disorders, at least in Japanese subjects, in contrast to the findings in British subjects. 11239712 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia. 11381257 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease BEFREE Failure to confirm NOTCH4 association with schizophrenia in a large population-based sample from Scotland. 11381258 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE Our data suggest a lack of association between the NOTCH4 gene triplet repeat polymorphism and schizophrenia in Japanese individuals. 11407996 2001
CUI: C0033975
Disease: Psychotic Disorders
Psychotic Disorders 		0.010 GeneticVariation group BEFREE We conducted a case-control study with Japanese subjects to explore an association between the triplet repeat polymorphism in the NOTCH4 gene and schizophrenia, including subtypes of schizophrenia, longitudinal disease course characteristics, and a positive family history for psychoses. 11407996 2001
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.050 AlteredExpression phenotype BEFREE Expression of "activated" Notch-4 in mammary epithelium has profound effects on mammary gland development and tumorigenesis. 11467450 2001
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.150 AlteredExpression disease BEFREE Notch-1 and -2 were strongly detected in both RA and OA, and the expression of Notch-3 was slightly detected, while there was no Notch-4 expression in both RA and OA synoviocytes. 11678296 2001
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.010 AlteredExpression disease BEFREE Notch-1 and -2 were strongly detected in both RA and OA, and the expression of Notch-3 was slightly detected, while there was no Notch-4 expression in both RA and OA synoviocytes. 11678296 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 Biomarker disease BEFREE Our results would indicate that a significant role for the Notch4 gene in schizophrenia can be ruled out in the Han Chinese. 11803454 2002
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease LHGDN Our results would indicate that a significant role for the Notch4 gene in schizophrenia can be ruled out in the Han Chinese. 11803454 2002
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.500 GeneticVariation disease BEFREE Based on the data suggesting overlapping susceptibility for schizophrenia and bipolar disorder, we genotyped the polymorphic (CTG)n encoding polyleucine repeat in exon 1 of NOTCH4 in 65 pedigrees ascertained for a genetic linkage study of bipolar disorder. 11901359 2002
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 GeneticVariation disease BEFREE Based on the data suggesting overlapping susceptibility for schizophrenia and bipolar disorder, we genotyped the polymorphic (CTG)n encoding polyleucine repeat in exon 1 of NOTCH4 in 65 pedigrees ascertained for a genetic linkage study of bipolar disorder. 11901359 2002
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.330 Biomarker disease PSYGENET Based on the data suggesting overlapping susceptibility for schizophrenia and bipolar disorder, we genotyped the polymorphic (CTG)n encoding polyleucine repeat in exon 1 of NOTCH4 in 65 pedigrees ascertained for a genetic linkage study of bipolar disorder. 11901359 2002
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.020 AlteredExpression group BEFREE Truncation of Notch1 has been shown to cause a subtype of acute leukemia, and activation of Notch4 has been associated with mammary and salivary gland carcinomas of mice. 12539049 2003
CUI: C0002170
Disease: Alopecia
Alopecia 		0.020 Biomarker disease BEFREE Notch4, a non-HLA gene in the MHC is strongly associated with the most severe form of alopecia areata. 12589427 2003
CUI: C0002171
Disease: Alopecia Areata
Alopecia Areata 		0.020 Biomarker disease BEFREE Notch4, a non-HLA gene in the MHC is strongly associated with the most severe form of alopecia areata. 12589427 2003