|
Hypertensive disease
|
0.540 |
GeneticVariation
|
group |
BEFREE |
The role of genetic polymorphisms in the LOX1 gene, however, remains unclear in the development of left ventricular hypertrophy (LVH) for patients with hypertension.
|
24480971 |
2014 |
|
Myocardial Infarction
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Independent association genetic studies have implicated OLR1 gene variants in myocardial infarction (MI) susceptibility.
|
15976314 |
2005 |
|
Myocardial Infarction
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Recently, a 3'-UTR (188 C>T) SNP in the OLR1 gene has been reported to be associated with coronary artery stenosis and myocardial infarction.
|
16829343 |
2006 |
|
Myocardial Infarction
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
Recently, LOX-1 gene polymorphism (G501C) was reported to be associated with myocardial infarction (MI).
|
15562935 |
2004 |
|
Myocardial Infarction
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
In humans, LOX-1 gene polymorphisms were associated with increased susceptibility to myocardial infarction.
|
23935243 |
2013 |
|
Myocardial Infarction
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that OLR1 or a neighboring gene linked with G501C SNP is important for the incidence of MI.
|
12646194 |
2003 |
|
Heart failure
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Deletion of LOX-1 Protects against Heart Failure Induced by Doxorubicin.
|
27195769 |
2016 |
|
Congestive heart failure
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
Deletion of LOX-1 Protects against Heart Failure Induced by Doxorubicin.
|
27195769 |
2016 |
|
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The up-regulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), encoded by the OLR1 gene, plays a fundamental role in the pathogenesis of atherosclerosis.
|
26542080 |
2016 |
|
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Both OLR1 and PCSK9 genes are associated with atherosclerosis, cardiovascular disease and ischemic stroke.
|
26666837 |
2015 |
|
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Proanthocyanidins are oligomers of catechins that exhibit potent antioxidative activity and inhibit binding of oxidized low-density lipoprotein (OxLDL) to the lectin-like oxidized LDL receptor (LOX-1), which is involved in the onset and development of arteriosclerosis.
|
29054360 |
2017 |
|
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The human oxidised low-density lipoprotein receptor 1 (OLR1) gene is a functional candidate for atherosclerosis.
|
16251892 |
2006 |
|
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that antagonism between SRSF1 and SRSF2/HMGA1, and differential recognition of their regulatory motifs depending on the identity of the rs3736234 polymorphism, influence OLR1 exon 5 inclusion and the efficiency of Ox-LDL uptake, with potential implications for atherosclerosis and coronary disease.
|
25904137 |
2015 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Both OLR1 and PCSK9 genes are associated with atherosclerosis, cardiovascular disease and ischemic stroke.
|
26666837 |
2015 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that antagonism between SRSF1 and SRSF2/HMGA1, and differential recognition of their regulatory motifs depending on the identity of the rs3736234 polymorphism, influence OLR1 exon 5 inclusion and the efficiency of Ox-LDL uptake, with potential implications for atherosclerosis and coronary disease.
|
25904137 |
2015 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The human oxidised low-density lipoprotein receptor 1 (OLR1) gene is a functional candidate for atherosclerosis.
|
16251892 |
2006 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The up-regulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), encoded by the OLR1 gene, plays a fundamental role in the pathogenesis of atherosclerosis.
|
26542080 |
2016 |
|
Cardiovascular Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our results show that the OLR1 gene polymorphism has little effect on an increased risk for ischemic CVD in the Japanese population.
|
17022953 |
2006 |
|
Cardiovascular Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In NASH, the LOX-1 polymorphism is associated with liver disease severity and may predispose to CVD through modulation of postprandial small TRLPs and adipokine balance and to diabetes by affecting both insulin secretion and insulin sensitivity.
|
21865331 |
2011 |
|
Cardiovascular Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Previous work identified six single nucleotide polymorphisms (SNPs) in linkage disequilibrium that influence the inclusion levels of OLR1 exon 5 and correlate with the risk of cardiovascular disease.
|
25904137 |
2015 |
|
Coronary Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Several studies have been carried out to explore the role of OLR-1 gene polymorphisms in the risk of coronary artery disease.
|
20136518 |
2010 |
|
Coronary Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Several genetic variants of LOX-1 are associated with the risk and severity of coronary artery disease.
|
30381837 |
2019 |
|
Coronary Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Manipulating LOX-1 activity might be a useful therapeutic and preventative approach for coronary artery disease, especially for individuals with the G501C genotype of OLR1.
|
12646194 |
2003 |
|
Coronary Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Scavenger Receptor LOX1 Genotype Predicts Coronary Artery Disease in Patients With Familial Hypercholesterolemia.
|
28941610 |
2017 |
|
Coronary Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Are IVS4 SNPs of OLR1 gene associated with coronary artery disease: Is there a linkage between IVS4 SNPs?
|
29558038 |
2018 |