|
Acute Cerebrovascular Accidents
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recently, studies have shown that sLOX-1 is also elevated in patients with acute stroke and can be a predictive biomarker for acute stroke.
|
30639239 |
2019 |
|
Acute Chest Syndrome
|
0.030 |
Biomarker
|
disease |
BEFREE |
Circulating levels of sLOX-1 are regarded as a risk biomarker for plaque rupture and acute coronary syndrome (ACS).
|
30639239 |
2019 |
|
Acute Chest Syndrome
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The OLR-1 G501C polymorphism might be associated with ACS in the Han Chinese population.
|
20136518 |
2010 |
|
Acute Chest Syndrome
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Oxidized low-density lipoprotein (lectin-like) receptor 1 (OLR1) was identified to be aberrantly activated in ACS and regulated by miR-9.
|
31571264 |
2020 |
|
Acute Coronary Syndrome
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Our study investigated whether the G501C and the 3'UTR C188T polymorphisms of the OLR-1 gene were genetic risk factors of acute coronary syndrome (ACS) in the Han Chinese population.
|
20136518 |
2010 |
|
Acute Coronary Syndrome
|
0.060 |
Biomarker
|
disease |
BEFREE |
This sLOX-1 plays a key role in the pathogenesis of atherosclerosis, and elevated sLOX-1 concentrations correlate with thin or ruptured fibrous caps in patients with acute coronary syndrome.
|
31708514 |
2020 |
|
Acute Coronary Syndrome
|
0.060 |
Biomarker
|
disease |
BEFREE |
MicroRNA-9 overexpression suppresses vulnerable atherosclerotic plaque and enhances vascular remodeling through negative regulation of the p38MAPK pathway via OLR1 in acute coronary syndrome.
|
31571264 |
2020 |
|
Acute Coronary Syndrome
|
0.060 |
Biomarker
|
disease |
BEFREE |
LOX-1 expression is elevated within vascular lesions and a serum soluble LOX-1 fragment appears diagnostic of patients with acute coronary syndromes.
|
18092947 |
2008 |
|
Acute Coronary Syndrome
|
0.060 |
Biomarker
|
disease |
LHGDN |
Lectin-like oxidized LDL receptor-1 (LOX-1) appears to play crucial roles in the pathogenesis of atherosclerotic plaque rupture and ACS onset.
|
16061745 |
2005 |
|
Acute Coronary Syndrome
|
0.060 |
Biomarker
|
disease |
BEFREE |
Circulating levels of sLOX-1 are regarded as a risk biomarker for plaque rupture and acute coronary syndrome (ACS).
|
30639239 |
2019 |
|
Acute myocardial infarction
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
In vivo and in vitro studies support that a new splicing isoform of OLR1 gene is protective against acute myocardial infarction.
|
15976314 |
2005 |
|
Acute myocardial infarction
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
An association of the OLR1 gene with acute myocardial infarction (AMI) or coronary artery disease (CAD) has recently been reported.
|
16251892 |
2006 |
|
Acute myocardial infarction
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
On this basis, we considered that OLR1 rs1050286 SNP may contribute to modify OLR1 susceptibility to AMI and CAD, so ORL1 SNPs screening could help to stratify patients risk.
|
26542080 |
2016 |
|
Acute myocardial ischemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Co-localization of LOX-1 along with ox-LDL in the rupture-prone plaque suggests that this receptor may be involved in the precipitation of acute myocardial ischemia.
|
15309203 |
2004 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Recent studies have indicated that olr1 mRNA is over-expressed in stage III and IV of human prostatic adenocarcinomas.
|
25170920 |
2014 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
C/EBPδ-Slug-Lox1 axis promotes metastasis of lung adenocarcinoma via oxLDL uptake.
|
31562393 |
2020 |
|
Alzheimer Disease, Late Onset
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We selected and genotyped three SNPs (rs1050283, rs1050286, rs17808009) in OLR1 to investigate its possible relationship with the onset of late-onset Alzheimer disease(LOAD) in 984 LOAD cases and 1,354 healthy controls among northern Han Chinese.
|
29951494 |
2018 |
|
Alzheimer Disease, Late Onset
|
0.030 |
Biomarker
|
disease |
BEFREE |
Because of its close proximity to the A2M gene and because it is abundantly expressed in the brain, we reasoned that the oxidized LDL-receptor 1 (OLR1) gene could be a candidate gene for AD.
|
12384789 |
2002 |
|
Alzheimer Disease, Late Onset
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The +1073 C/T polymorphism of the oxidized low-density lipoprotein receptor-1 (OLR1) gene has been reported to be associated with late-onset Alzheimer's disease, whereas for the +1071 T/A polymorphism no association was found.
|
15860461 |
2005 |
|
Alzheimer's Disease
|
0.090 |
GeneticVariation
|
disease |
LHGDN |
In conclusion, our data suggest that genetic variation in the OLR1 gene may modify the risk of AD.
|
12807963 |
2003 |
|
Alzheimer's Disease
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The OLR1 rs1050283 SNP likely acts as a risk factor for sporadic AD.
|
21709374 |
2011 |
|
Alzheimer's Disease
|
0.090 |
Biomarker
|
disease |
BEFREE |
OLR1 is a good candidate gene, due to its function in lipid metabolism pathways, other components of which have been previously implicated as risk factors for AD.
|
15276231 |
2004 |
|
Alzheimer's Disease
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we have investigated the extent of amyloid beta protein (Abeta) deposition as cerebral amyloid angiopathy (CAA) or senile plaques (SP) in relationship to OLR1 +1071 and +1073 polymorphisms and LRP1 C766T polymorphism in patients with AD There was an increased Abeta40 load as CAA, but not as SP, in frontal cortex of AD patients carrying OLR1+1073 CC genotype, compared to those with CT, TT or CT+TT genotypes, but only in those individuals without apolipoprotein (APOE) epsilon4 allele.
|
16328515 |
2006 |
|
Alzheimer's Disease
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Several SNPs within OLR1 have been reported to have association with AD among Caucasians.
|
29951494 |
2018 |
|
Alzheimer's Disease
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in different susceptibility genes on chromosome 12 (A2M, LRP1, CP2 and OLR1) are now being suggested as possible genetic markers for increased risk of developing AD.
|
16183100 |
2006 |