|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Results suggest that the PCNA index in cervical and endometrial adenocarcinomas and the pretreatment tumor volume in endometrial adenocarcinoma appeared to be potentially useful in predicting the immediate response to the chemotherapy.
|
9159335 |
1997 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
The staining differences between LMP tumors and adenocarcinomas with antibodies against Ki-67, PCNA, and P-glycoprotein were not statistically significant.
|
9398993 |
1997 |
|
Malignant neoplasm of lung
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To examine the role of elevated glucose uptake in lung cancer, we performed PCR amplification of 2 facilitative glucose transporter genes (GLUT1 and GLUT3) and immunohistochemical staining for GLUT1, proliferating cell nuclear antigen (PCNA), and sialyl Lewis x (sLe(x)) on tumor specimens from 327 patients with lung cancer who underwent surgical resection from 1980 to 1993.
|
9133454 |
1997 |
|
Adenocarcinoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The authors examined three cell-biological parameters--DNA status, proliferating cell-nuclear antigen (PCNA) immunostaining, and argyrophilic nucleolar-organizer region (AgNOR) counts--in surgically resected, formalin-fixed, paraffin-embedded urachal adenocarcinomas from 41 patients.
|
8600037 |
1996 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
A surprising finding was that S-phase percentage in adenocarcinomas was not parallel with PCNA-positive tumor cell numbers.
|
7729290 |
1995 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Thirty-five adenomas and 60 adenocarcinomas were studied immunohistochemically concerning proliferating cell nuclear antigen positivity in tumor cell nuclei.
|
7956574 |
1994 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The expression of proliferating cell nuclear antigen and p53 protein was analysed by immunocytochemical methods (PC10, CM1 antisera) in 139 patients with T1-2M0 prostatic adenocarcinomas followed-up for > 12 years. p53 protein was expressed in 21 (15%) tumours (15%), the fraction of positive nuclei being very low (mean SE, 1% +/- 0.7%).
|
7913085 |
1994 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
A linear correlation between numbers of ISH signals and PCNA expression was not demonstrated, but there was a tendency of increasing PCNA positivity according to increasing numbers of ISH signals in adenocarcinomas of the lung and the tumor tissues which were over 50% positive PCNA expression.
|
7911024 |
1993 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Studies by PCNA (proliferating cell nuclear antigen) immunohistochemistry, showed that in over half of the gastric-type adenocarcinomas cases PCNA-positive cells tended to be localized within tumor tissues.
|
7903667 |
1993 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Mean PCNA expression was higher in squamous carcinomas than in adenocarcinomas but there was marked intra-tumour variation in PCNA index in almost all cases.
|
1351473 |
1992 |
|
Malignant neoplasm of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of proliferating cell nuclear antigen in lung cancer: a systematic study and correlation with DNA ploidy.
|
1351473 |
1992 |
|
Lung Neoplasms
|
0.350 |
Biomarker
|
group |
BEFREE |
We show this association of PRPRT methylation with upregulation of the STAT3 target genes <i>Cyclin D1</i> and <i>Bcl-X<sub>L</sub></i> in patient derived lung tumour samples.
|
31595832 |
2019 |
|
Lung Neoplasms
|
0.350 |
AlteredExpression
|
group |
BEFREE |
We evaluated the proliferative activity in 62 primary lung tumors by determining the cell's percentage of Ki-67 and immunoreactive PCNA (using MIB-1 and PCNA monoclonal antibodies), classifying Ki-67 and PCNA immunoreactivity into three score groups.
|
29940632 |
2018 |
|
Malignant tumor of colon
|
0.350 |
Biomarker
|
disease |
BEFREE |
In our research, we used transcriptional methods and immunohistochemistry to investigate the LGR5 gene and protein expression, examined proliferating cell nuclear antigen(PCNA) and Ki67 which were the classic markers for cell proliferation in LGR5 protein positive and negative colon cancer among mice model and patients.
|
24063790 |
2014 |
|
Malignant tumor of colon
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Functional analysis of cellular proliferative activities, by MTT assay, and invasive potential, by Transwell assay, was conducted on SW620 cells expressing low levels of miR‑185. miR‑185 was found to be significantly downregulated in cancer tissues compared with adjacent non‑cancerous tissues, and was negatively correlated with lymph node metastasis of colon cancer (P<0.001). miR‑185 overexpression in vitro impeded cellular proliferation and invasive potential with reduced expression of HIF‑2α, PCNA and MMP‑2 in SW620 cells transfected with an miR‑185 mimic.
|
25216407 |
2014 |
|
Malignant tumor of colon
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
This effect was accompanied by pro-apoptosis of C086 in colon cancer cells and lower expression of PCNA in C086 treated colon cancer xenografts.
|
21900746 |
2011 |
|
Malignant tumor of colon
|
0.350 |
Biomarker
|
disease |
CTD_human |
5-Azacytidine prevents cisplatin induced nephrotoxicity and potentiates anticancer activity of cisplatin by involving inhibition of metallothionein, pAKT and DNMT1 expression in chemical induced cancer rats.
|
19723570 |
2009 |
|
Malignant tumor of colon
|
0.350 |
Biomarker
|
disease |
CTD_human |
Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats.
|
19028472 |
2009 |
|
Malignant tumor of colon
|
0.350 |
Biomarker
|
disease |
BEFREE |
We further showed that the colon cancer cell line expressing the wild-type APC gene was more sensitive to a DNA-methylating agent due to decreased DNA repair by long patch BER than the cell line expressing the mutant APC gene lacking the proliferating cell nuclear antigen-interacting protein-like box.
|
15548520 |
2005 |
|
Lung Neoplasms
|
0.350 |
AlteredExpression
|
group |
LHGDN |
[18F]FDG uptake and PCNA, Glut-1, and Hexokinase-II expressions in cancers and inflammatory lesions of the lung.
|
15967114 |
2005 |
|
Lung Neoplasms
|
0.350 |
Biomarker
|
group |
CTD_human |
Levels of K-ras p21, raf-1, mitogen-activated protein kinases Erk 1 and 2, the phosphorylated-activated forms of Erk 1 and 2 (Erk 1P and 2P), and proliferating cell nuclear antigen (PCNA) were measured by immunoblotting in mouse lung tumors (5 to 9 mm in size) caused by N-nitrosodimethylamine (NDMA) and in control lungs.
|
11884234 |
2002 |
|
Lung Neoplasms
|
0.350 |
AlteredExpression
|
group |
BEFREE |
We examined lung tumors 1-7 mm in largest dimension initiated in male Swiss mice by N-nitrosodimethylamine for pathologic type, Ki-ras mutations and levels of total Ki-ras p21, Ki-ras p21 bound to GTP, raf-1, Erk1 and Erk2 and their phosphorylated (activated) forms, and proliferating cell nuclear antigen.
|
10942532 |
2000 |
|
Malignant tumor of colon
|
0.350 |
Biomarker
|
disease |
BEFREE |
The expressions of p53 and proliferating cell nuclear antigen (PCNA) were studied immunohistochemically from paraffin sections of 7 cases (9 lesions) of radiation-induced colon cancer and 42 cases of spontaneous colon cancer.
|
9610028 |
1998 |
|
Lung Neoplasms
|
0.350 |
AlteredExpression
|
group |
BEFREE |
To better understand the relationship between specific chromosome changes found in human lung tumors and their phenotypic consequences a the tissue level, an in situ hybridization (ISH) procedure of chromosome 17 and immunohistochemistry of proliferating cell nuclear antigen (PCNA) were done.
|
7911024 |
1993 |
|
Psoriasis
|
0.330 |
Biomarker
|
disease |
BEFREE |
White mange mixture can significantly inhibit vaginal psoriasis in a mouse model by decreasing the amount of epithelium KC cell PCNA and production of the inflammatory cytokines GM-CSF in serum.
|
31384318 |
2019 |