|
Lupus Erythematosus, Discoid
|
0.010 |
Biomarker
|
disease |
BEFREE |
A rabbit antiserum raised against an NH2-terminal peptide, a well-characterized murine monoclonal antibody (mAb), and 14 human lupus sera with autoantibody to PCNA were analyzed for their reactivity with the constructs using both immunoprecipitation and immunoblotting techniques.
|
1695666 |
1990 |
|
Acute leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We have examined by two-dimensional polyacrylamide gel electrophoresis the expression of PCNA in various subtypes of childhood acute leukemia and have found differences in its expression according to subtype.
|
1975505 |
1990 |
|
Lupus Erythematosus
|
0.010 |
Biomarker
|
disease |
BEFREE |
A rabbit antiserum raised against an NH2-terminal peptide, a well-characterized murine monoclonal antibody (mAb), and 14 human lupus sera with autoantibody to PCNA were analyzed for their reactivity with the constructs using both immunoprecipitation and immunoblotting techniques.
|
1695666 |
1990 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor labeling index (LI) was determined after in vitro 5-bromodeoxyuridine incorporation, while proliferating cell nuclear antigen LI was determined immunohistochemically.
|
1676611 |
1991 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The percentage of tumour cells with positive staining for PCNA was found to correlate well with histological grading.
|
1680785 |
1991 |
|
IGA Glomerulonephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These findings indicate that abnormally regulated PCNA expression in PBMC may play an important role in the progression of IgA nephropathy, and that PCNA expression in PBMC may be a useful indicator of disease activity.
|
1681731 |
1991 |
|
Adenocarcinoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Mean PCNA expression was higher in squamous carcinomas than in adenocarcinomas but there was marked intra-tumour variation in PCNA index in almost all cases.
|
1351473 |
1992 |
|
Malignant neoplasm of lung
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of proliferating cell nuclear antigen in lung cancer: a systematic study and correlation with DNA ploidy.
|
1351473 |
1992 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Comparison of PCNA/cyclin immunohistochemistry with flow cytometric S-phase fraction in breast cancer.
|
1356517 |
1992 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemistry showed altered localization of p62c-myc, i.e., both cytoplasmic and nuclear immunostaining in advanced carcinomas. c-myc immunoreactivity exhibited wider distribution compared with that of PCNA, a cell cycle related antigen, which may indicate induction of cell proliferation by p62c-myc.
|
1444241 |
1992 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Proliferative activity was measured in 165 paraffin-embedded prostatic carcinomas using DNA flow cytometric analysis of the S-phase (SPF) and G2/M-phase fractions and CAS 200 image analysis of the proliferating cell nuclear antigen (PCNA) expression defined immunohistochemically by PC10 and 19A2 monoclonal antibodies.
|
1360498 |
1992 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Heterogeneity of expression of the proliferating cell nuclear antigen (PCNA) was assessed immunohistochemically in 156 tissue samples from 33 surgically resected pulmonary carcinomas using the monoclonal antibody 19A2.
|
1351473 |
1992 |
|
Non-Small Cell Lung Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Results indicate that PCNA labeling with PC10 is a simple method for assessing the proliferative activity in formalin-fixed, paraffin-embedded tissue of NSCLC and correlates well with Ki-67 labeling and S-phase fraction of the cell cycle.
|
1361306 |
1992 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Its frequency ranged from 0 to 80% (37.7 +/- 23.6) and larger sized, early-staged and DNA aneuploid tumors expressed a significant higher number of PCNA-reactive cells.
|
1361306 |
1992 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The wide variation in PCNA expression between different samples within a tumour would indicate that systematic sampling and counting will be necessary in future immunohistochemical studies of cell proliferation in tumour material.
|
1351473 |
1992 |
|
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Proliferative activity determined by DNA flow cytometry and proliferating cell nuclear antigen (PCNA) immunohistochemistry as a prognostic factor in prostatic carcinoma.
|
1360498 |
1992 |
|
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Comparison of PCNA/cyclin immunohistochemistry with flow cytometric S-phase fraction in breast cancer.
|
1356517 |
1992 |
|
Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of proliferating cell nuclear antigen in lung cancer: a systematic study and correlation with DNA ploidy.
|
1351473 |
1992 |
|
Primary malignant neoplasm of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of proliferating cell nuclear antigen in lung cancer: a systematic study and correlation with DNA ploidy.
|
1351473 |
1992 |
|
Carcinoid Tumor
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Labelling of consecutive sections with antibodies against IGF-I and proliferating cell nuclear antigen (PCNA)/cyclin demonstrated a co-distribution of the 2 antigens in carcinoid tumours.
|
1314781 |
1992 |
|
Pilar and trichilemmal cysts
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We have examined proliferative activity in a series of pilar and trichilemmal cysts using an antibody to proliferating cell nuclear antigen.
|
1360441 |
1992 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
A linear correlation between numbers of ISH signals and PCNA expression was not demonstrated, but there was a tendency of increasing PCNA positivity according to increasing numbers of ISH signals in adenocarcinomas of the lung and the tumor tissues which were over 50% positive PCNA expression.
|
7911024 |
1993 |
|
Adenocarcinoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Studies by PCNA (proliferating cell nuclear antigen) immunohistochemistry, showed that in over half of the gastric-type adenocarcinomas cases PCNA-positive cells tended to be localized within tumor tissues.
|
7903667 |
1993 |
|
Lung Neoplasms
|
0.350 |
AlteredExpression
|
group |
BEFREE |
To better understand the relationship between specific chromosome changes found in human lung tumors and their phenotypic consequences a the tissue level, an in situ hybridization (ISH) procedure of chromosome 17 and immunohistochemistry of proliferating cell nuclear antigen (PCNA) were done.
|
7911024 |
1993 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In contrast, there was no correlation between c-myc overexpression, found in 19 out of 40 HCC (47.5%), and histological grading of HCC or PCNA labeling index.
|
8104947 |
1993 |