|
Adolescent idiopathic scoliosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
Cheyne-Stokes Respiration
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Background The contribution of the lung or the plant gain ( PG ; ie, change in blood gases per unit change in ventilation) to Cheyne-Stokes respiration ( CSR ) in heart failure has only been hypothesized by mathematical models, but never been directly evaluated.
|
31237174 |
2019 |
|
Craniosynostosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here, we describe a patient whose features we would suggest represent a new FGFR2-related syndrome, craniosynostosis with XY male-to-female sex reversal or CSR.
|
26362256 |
2015 |
|
Malignant neoplasm of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Within the CSR gene set, a group of 42 v-Src inducible genes was associated with reduced disease- and metastasis-free survival in several independent patient cohorts with breast or lung cancer.
|
20152043 |
2010 |
|
Malignant Childhood Neoplasm
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In 22 childhood cancer survivors (median age: 14.8, range 6.4-21.6 years), mean GLS (- 13.83 ± 0.74% to - 15.94 ± 0.74%, p = 0.002), GCS (- 18.79 ± 1.21% to - 20.74 ± 0.84%, p = 0.027), LSR (- 0.78 ± 0.04 to - 0.88 ± 0.04 s<sup>-1</sup>, p = 0.022), and CSR (- 1.08 ± 0.07 to - 1.21 ± 0.06 s<sup>-1</sup>, p = 0.027) improved on therapy.
|
29789916 |
2018 |
|
Carcinoma of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Within the CSR gene set, a group of 42 v-Src inducible genes was associated with reduced disease- and metastasis-free survival in several independent patient cohorts with breast or lung cancer.
|
20152043 |
2010 |
|
Vegetation
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We measured 16 different functional traits and then ordinated the resulting vegetation within the CSR triangle using StrateFy.
|
28388622 |
2017 |
|
Primary malignant neoplasm of lung
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Within the CSR gene set, a group of 42 v-Src inducible genes was associated with reduced disease- and metastasis-free survival in several independent patient cohorts with breast or lung cancer.
|
20152043 |
2010 |
|
Recurrent Childhood Glioblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this phase I clinical study, we evaluated the safety and bioactivity of CSR-T cell therapy in 14 patients with recurrent glioblastoma who were unresponsive to surgical resection and standard radiotherapy.
|
31136972 |
2019 |
|
Recurrent Glioblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this phase I clinical study, we evaluated the safety and bioactivity of CSR-T cell therapy in 14 patients with recurrent glioblastoma who were unresponsive to surgical resection and standard radiotherapy.
|
31136972 |
2019 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Transgenic mouse models of T(12;15)/t(8;14), including newly developed "iMyc" gene-insertion mice, will be useful in elucidating the role of these CSR factors in the progression of Myc-induced B cell tumors.
|
16815105 |
2006 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
A clustering enrichment regime using the CSR genes and two independent breast tumor data-sets was used to identify a 42-gene aggressive tumor gene signature.
|
20152043 |
2010 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
The present findings suggest that CSR1 is a potent tumor sup-pressor gene.
|
16436673 |
2006 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Cellular stress response 1 (CSR1) is a tumor suppressor gene that plays an important role in regulating cell death.
|
27148859 |
2017 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
Cellular Stress Response 1 (CSR1) is a tumor suppressor gene and frequently deleted in prostate cancers.
|
29705808 |
2018 |
|
Neoplasms
|
0.080 |
Biomarker
|
group |
BEFREE |
CSR1 suppresses tumor growth and metastasis of human hepatocellular carcinoma via inhibition of HPIP.
|
28975986 |
2017 |
|
Malignant neoplasm of prostate
|
0.040 |
Biomarker
|
disease |
BEFREE |
Cellular Stress Response 1 (CSR1) is a tumor suppressor gene and frequently deleted in prostate cancers.
|
29705808 |
2018 |
|
Heart failure
|
0.030 |
Biomarker
|
disease |
BEFREE |
Conclusions PG is a powerful contributor of CSR and should be evaluated together with the CG and circulation time to individualize treatments aimed at stabilizing breathing in heart failure.
|
31237174 |
2019 |
|
Heart failure
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our findings suggest the novel concept that the negative pattern of CSR-CSA may constitute a form of auto-resuscitation that acts as a compensatory mechanism to maintain SV in patients with severe HF.
|
30946471 |
2019 |
|
Heart failure
|
0.030 |
Biomarker
|
disease |
BEFREE |
This study investigated the association of microstructural cerebral lesions with central sleep apnea with Cheyne-Stokes-respiration (CSA-CSR) in heart failure (HF) patients and the effect of positive airway pressure therapy (PAP) of CSA-CSR on these lesions.
|
29102807 |
2018 |
|
Congestive heart failure
|
0.030 |
Biomarker
|
disease |
BEFREE |
This study investigated the association of microstructural cerebral lesions with central sleep apnea with Cheyne-Stokes-respiration (CSA-CSR) in heart failure (HF) patients and the effect of positive airway pressure therapy (PAP) of CSA-CSR on these lesions.
|
29102807 |
2018 |
|
Congestive heart failure
|
0.030 |
Biomarker
|
disease |
BEFREE |
Conclusions PG is a powerful contributor of CSR and should be evaluated together with the CG and circulation time to individualize treatments aimed at stabilizing breathing in heart failure.
|
31237174 |
2019 |
|
Congestive heart failure
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our findings suggest the novel concept that the negative pattern of CSR-CSA may constitute a form of auto-resuscitation that acts as a compensatory mechanism to maintain SV in patients with severe HF.
|
30946471 |
2019 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
CSR1 suppresses tumor growth and metastasis of human hepatocellular carcinoma via inhibition of HPIP.
|
28975986 |
2017 |