|
mathematical ability
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
|
30038396 |
2018 |
|
Major Depressive Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
A mega-analysis of genome-wide association studies for major depressive disorder.
|
22472876 |
2013 |
|
Neoplasms
|
0.050 |
GeneticVariation
|
group |
BEFREE |
Minor allele carriers of two REV1 SNPs (rs6761391 and rs3792142) had significantly more often large tumours and tumours with high histological grade and stage.
|
21455670 |
2011 |
|
Malignant neoplasm of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk.
|
15609317 |
2005 |
|
Carcinoma of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk.
|
15609317 |
2005 |
|
Primary malignant neoplasm of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk.
|
15609317 |
2005 |
|
Leukopenia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Polymorphic REV1 rs3087403 allele and REV1 TGT haplotype were associated with increased risk for leukopenia (p = 0.013 and p = 0.047, respectively) and neutropenia (p = 0.048 and p = 0.024, respectively).
|
24956248 |
2014 |
|
Neutropenia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Polymorphic REV1 rs3087403 allele and REV1 TGT haplotype were associated with increased risk for leukopenia (p = 0.013 and p = 0.047, respectively) and neutropenia (p = 0.048 and p = 0.024, respectively).
|
24956248 |
2014 |
|
Cervical Squamous Cell Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Compared with the REV1 Phe257Ser, women carrying Ser257Ser and Phe257Ser genotypes had a significantly decreased the risk for cervical carcinoma or cervical squamous cell carcinoma.
|
18470628 |
2008 |
|
Cervix carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Compared with the REV1 Phe257Ser, women carrying Ser257Ser and Phe257Ser genotypes had a significantly decreased the risk for cervical carcinoma or cervical squamous cell carcinoma.
|
18470628 |
2008 |
|
Human papilloma virus infection
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Two single nucleotide polymorphisms (SNPs) (REV1 Phe257Ser and REV1 Asn373Ser) were genotyped by PCR-squencing, and analysis the correlation to clinical character including HPV infection.
|
18470628 |
2008 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
As such, inhibition of Rev1/Polζ-dependent TLS has recently emerged as a strategy to enhance the efficacy of first-line chemotherapy and reduce the acquisition of chemoresistance by decreasing tumor mutation rate.
|
28541665 |
2017 |
|
Brucellosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
<i>Brucella abortus</i> strain 19 (S19), <i>Brucella melitensis</i> Rev 1 (Rev1), and <i>B. abortus</i> strain RB51 (RB51) are the three licensed animal brucellosis vaccines, and they have been most commonly and successfully used in prevent brucellosis in animals.
|
29867505 |
2018 |
|
Brucellosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Effective control of sheep and goat brucellosis has been achieved in several countries through vaccination with the live-attenuated B. melitensis Rev1 vaccine.
|
30375177 |
2019 |
|
Brucellosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Furthermore, vaccination of cattle with S19 in addition to vaccination of small ruminants with Rev 1 might be needed in order to control Brucella infections in the livestock population but further research focusing on the isolation of Brucella is required to obtain a comprehensive understanding of the Brucella spp. circulating among the livestock in this region.
|
28296882 |
2017 |
|
Brucellosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Live attenuated Brucella melitensis Rev 1 is the most effective vaccine against brucellosis in small ruminants.
|
17050051 |
2007 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
REV1-POL ζ Inhibition and Cancer Therapy.
|
31398321 |
2019 |
|
Congenital chromosomal disease
|
0.020 |
Biomarker
|
group |
BEFREE |
Consistent with a role downstream of the FA core complex and like known FA proteins, Rev1 is required to prevent DNA crosslinker-induced chromosomal aberrations in human cells.
|
18448394 |
2008 |
|
Congenital chromosomal disease
|
0.020 |
Biomarker
|
group |
BEFREE |
Third, we present evidence that REV1 and Polzeta are uniquely associated with protection against cisplatin and mitomycin C-induced chromosomal aberrations, and both are necessary for the timely resolution of DNA double-strand breaks associated with repair of DNA interstrand cross-links.
|
20028736 |
2010 |
|
Fanconi Anemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
The recently described role of the Fanconi anemia pathway in regulating Rev1 and Polζ-dependent TLS is also discussed in terms of their involvement in TLS, interstrand crosslink repair, and homologous recombination.
|
23195997 |
2013 |
|
Fanconi Anemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results suggest a role for the FA core complex in regulating Rev1-dependent DNA damage tolerance independently of FANCD2, FANCI, and PCNA monoubiquitination.
|
18448394 |
2008 |
|
Malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our findings suggested that genetic variants in POLκ and PCNA genes may play roles in the susceptibility of lung cancer, and REV1 gene may have roles in lung cancer survival in Chinese men.
|
24012694 |
2013 |
|
Brucella melitensis infection
|
0.020 |
Biomarker
|
disease |
BEFREE |
Live attenuated Brucella melitensis Rev 1 is the most effective vaccine against brucellosis in small ruminants.
|
17050051 |
2007 |
|
Brucella melitensis infection
|
0.020 |
Biomarker
|
disease |
BEFREE |
GFP tagging of Brucella melitensis Rev1 allows the identification of vaccinated sheep.
|
30375177 |
2019 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
We selected four genes encoding for the catalytic subunits of the polymerases β, δ, θ and ζ (POLB, POLD1, POLQ and REV3L, respectively) and two associated proteins (MAD2L2 and REV1) because of their previously reported association with chromosomal instability and/or tumorigenesis.
|
21455670 |
2011 |