REV1, REV1 DNA directed polymerase, 51455

N. diseases: 28; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.050 AlteredExpression group BEFREE The expression of the human K-rev-1 gene, a known tumour-suppressor gene in ras-transformed NIH3T3 cells, was studied in the isolated azatyrosine revertants. 1741165 1992
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.050 AlteredExpression group BEFREE Western blot analysis of tumor reconstitutes demonstrated that there was no decrease or loss of introduced K-rev-1 protein expression. 8275494 1994
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.050 AlteredExpression group BEFREE The S29 ribosomal protein increases tumor suppressor activity of K rev-1 gene on v-K ras-transformed NIH3T3 cells. 8781548 1996
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.050 Biomarker group BEFREE As such, inhibition of Rev1/Polζ-dependent TLS has recently emerged as a strategy to enhance the efficacy of first-line chemotherapy and reduce the acquisition of chemoresistance by decreasing tumor mutation rate. 28541665 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.050 GeneticVariation group BEFREE Minor allele carriers of two REV1 SNPs (rs6761391 and rs3792142) had significantly more often large tumours and tumours with high histological grade and stage. 21455670 2011
CUI: C0006309
Disease: Brucellosis
Brucellosis 		0.040 Biomarker disease BEFREE <i>Brucella abortus</i> strain 19 (S19), <i>Brucella melitensis</i> Rev 1 (Rev1), and <i>B. abortus</i> strain RB51 (RB51) are the three licensed animal brucellosis vaccines, and they have been most commonly and successfully used in prevent brucellosis in animals. 29867505 2018
CUI: C0006309
Disease: Brucellosis
Brucellosis 		0.040 Biomarker disease BEFREE Effective control of sheep and goat brucellosis has been achieved in several countries through vaccination with the live-attenuated B. melitensis Rev1 vaccine. 30375177 2019
CUI: C0006309
Disease: Brucellosis
Brucellosis 		0.040 Biomarker disease BEFREE Furthermore, vaccination of cattle with S19 in addition to vaccination of small ruminants with Rev 1 might be needed in order to control Brucella infections in the livestock population but further research focusing on the isolation of Brucella is required to obtain a comprehensive understanding of the Brucella spp. circulating among the livestock in this region. 28296882 2017
CUI: C0006309
Disease: Brucellosis
Brucellosis 		0.040 Biomarker disease BEFREE Live attenuated Brucella melitensis Rev 1 is the most effective vaccine against brucellosis in small ruminants. 17050051 2007
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 AlteredExpression group BEFREE We used information from the Cancer Cell Line Encyclopedia and the Genomics of Drug Sensitivity in Cancer resources to examine associations of the prevalence of APOBEC-like motifs and mutational loads with expression of APOBEC3A, APOBEC3B, REV1, UNG, and FHIT and with cell line chemosensitivity to 255 antitumor drugs. 29642934 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 Biomarker group BEFREE REV1-POL ζ Inhibition and Cancer Therapy. 31398321 2019
CUI: C0008626
Disease: Congenital chromosomal disease
Congenital chromosomal disease 		0.020 Biomarker group BEFREE Consistent with a role downstream of the FA core complex and like known FA proteins, Rev1 is required to prevent DNA crosslinker-induced chromosomal aberrations in human cells. 18448394 2008
CUI: C0008626
Disease: Congenital chromosomal disease
Congenital chromosomal disease 		0.020 Biomarker group BEFREE Third, we present evidence that REV1 and Polzeta are uniquely associated with protection against cisplatin and mitomycin C-induced chromosomal aberrations, and both are necessary for the timely resolution of DNA double-strand breaks associated with repair of DNA interstrand cross-links. 20028736 2010
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia 		0.020 Biomarker disease BEFREE The recently described role of the Fanconi anemia pathway in regulating Rev1 and Polζ-dependent TLS is also discussed in terms of their involvement in TLS, interstrand crosslink repair, and homologous recombination. 23195997 2013
CUI: C0015625
Disease: Fanconi Anemia
Fanconi Anemia 		0.020 Biomarker disease BEFREE Our results suggest a role for the FA core complex in regulating Rev1-dependent DNA damage tolerance independently of FANCD2, FANCI, and PCNA monoubiquitination. 18448394 2008
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.020 Biomarker disease BEFREE Our findings suggested that genetic variants in POLκ and PCNA genes may play roles in the susceptibility of lung cancer, and REV1 gene may have roles in lung cancer survival in Chinese men. 24012694 2013
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.020 GeneticVariation disease BEFREE Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk. 15609317 2005
CUI: C0302362
Disease: Brucella melitensis infection
Brucella melitensis infection 		0.020 Biomarker disease BEFREE Live attenuated Brucella melitensis Rev 1 is the most effective vaccine against brucellosis in small ruminants. 17050051 2007
CUI: C0302362
Disease: Brucella melitensis infection
Brucella melitensis infection 		0.020 Biomarker disease BEFREE GFP tagging of Brucella melitensis Rev1 allows the identification of vaccinated sheep. 30375177 2019
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.020 Biomarker phenotype BEFREE We selected four genes encoding for the catalytic subunits of the polymerases β, δ, θ and ζ (POLB, POLD1, POLQ and REV3L, respectively) and two associated proteins (MAD2L2 and REV1) because of their previously reported association with chromosomal instability and/or tumorigenesis. 21455670 2011
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.020 Biomarker phenotype BEFREE In this study, we generated a novel Rev1-overexpressing transgenic (Tg) mouse and characterized its susceptibility to tumorigenesis. 28498946 2017
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.020 Biomarker disease BEFREE Our findings suggested that genetic variants in POLκ and PCNA genes may play roles in the susceptibility of lung cancer, and REV1 gene may have roles in lung cancer survival in Chinese men. 24012694 2013
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.020 GeneticVariation disease BEFREE Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk. 15609317 2005
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.020 AlteredExpression group BEFREE We used information from the Cancer Cell Line Encyclopedia and the Genomics of Drug Sensitivity in Cancer resources to examine associations of the prevalence of APOBEC-like motifs and mutational loads with expression of APOBEC3A, APOBEC3B, REV1, UNG, and FHIT and with cell line chemosensitivity to 255 antitumor drugs. 29642934 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.020 Biomarker group BEFREE REV1-POL ζ Inhibition and Cancer Therapy. 31398321 2019