|
Brucellosis in animals
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>Brucella abortus</i> strain 19 (S19), <i>Brucella melitensis</i> Rev 1 (Rev1), and <i>B. abortus</i> strain RB51 (RB51) are the three licensed animal brucellosis vaccines, and they have been most commonly and successfully used in prevent brucellosis in animals.
|
29867505 |
2018 |
|
Brucellosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
<i>Brucella abortus</i> strain 19 (S19), <i>Brucella melitensis</i> Rev 1 (Rev1), and <i>B. abortus</i> strain RB51 (RB51) are the three licensed animal brucellosis vaccines, and they have been most commonly and successfully used in prevent brucellosis in animals.
|
29867505 |
2018 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
REV1-POL ζ Inhibition and Cancer Therapy.
|
31398321 |
2019 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
REV1-POL ζ Inhibition and Cancer Therapy.
|
31398321 |
2019 |
|
Major Depressive Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
A mega-analysis of genome-wide association studies for major depressive disorder.
|
22472876 |
2013 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
As such, inhibition of Rev1/Polζ-dependent TLS has recently emerged as a strategy to enhance the efficacy of first-line chemotherapy and reduce the acquisition of chemoresistance by decreasing tumor mutation rate.
|
28541665 |
2017 |
|
Malignant neoplasm of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk.
|
15609317 |
2005 |
|
Carcinoma of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk.
|
15609317 |
2005 |
|
Primary malignant neoplasm of lung
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk.
|
15609317 |
2005 |
|
Cervix carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Compared with the REV1 Phe257Ser, women carrying Ser257Ser and Phe257Ser genotypes had a significantly decreased the risk for cervical carcinoma or cervical squamous cell carcinoma.
|
18470628 |
2008 |
|
Cervical Squamous Cell Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Compared with the REV1 Phe257Ser, women carrying Ser257Ser and Phe257Ser genotypes had a significantly decreased the risk for cervical carcinoma or cervical squamous cell carcinoma.
|
18470628 |
2008 |
|
Congenital chromosomal disease
|
0.020 |
Biomarker
|
group |
BEFREE |
Consistent with a role downstream of the FA core complex and like known FA proteins, Rev1 is required to prevent DNA crosslinker-induced chromosomal aberrations in human cells.
|
18448394 |
2008 |
|
Brucellosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Effective control of sheep and goat brucellosis has been achieved in several countries through vaccination with the live-attenuated B. melitensis Rev1 vaccine.
|
30375177 |
2019 |
|
Fibrosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, survival and mutagenesis assays in mouse embryonic fibroblasts and human fibrosarcoma HT1080 cells treated with cisplatin and ultraviolet light indicate that these compounds inhibit mutagenic Rev1/Polζ-dependent TLS in cells, validating the Rev1-CT/RIR PPI for future anticancer drug discovery and identifying the first small molecule inhibitors of TLS that target Rev1-CT.
|
28541665 |
2017 |
|
Adult Fibrosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, survival and mutagenesis assays in mouse embryonic fibroblasts and human fibrosarcoma HT1080 cells treated with cisplatin and ultraviolet light indicate that these compounds inhibit mutagenic Rev1/Polζ-dependent TLS in cells, validating the Rev1-CT/RIR PPI for future anticancer drug discovery and identifying the first small molecule inhibitors of TLS that target Rev1-CT.
|
28541665 |
2017 |
|
Brucellosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Furthermore, vaccination of cattle with S19 in addition to vaccination of small ruminants with Rev 1 might be needed in order to control Brucella infections in the livestock population but further research focusing on the isolation of Brucella is required to obtain a comprehensive understanding of the Brucella spp. circulating among the livestock in this region.
|
28296882 |
2017 |
|
mathematical ability
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.
|
30038396 |
2018 |
|
Brucella melitensis infection
|
0.020 |
Biomarker
|
disease |
BEFREE |
GFP tagging of Brucella melitensis Rev1 allows the identification of vaccinated sheep.
|
30375177 |
2019 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In this study, we generated a novel Rev1-overexpressing transgenic (Tg) mouse and characterized its susceptibility to tumorigenesis.
|
28498946 |
2017 |
|
Brucella melitensis infection
|
0.020 |
Biomarker
|
disease |
BEFREE |
Live attenuated Brucella melitensis Rev 1 is the most effective vaccine against brucellosis in small ruminants.
|
17050051 |
2007 |
|
Brucellosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Live attenuated Brucella melitensis Rev 1 is the most effective vaccine against brucellosis in small ruminants.
|
17050051 |
2007 |
|
Neoplasms
|
0.050 |
GeneticVariation
|
group |
BEFREE |
Minor allele carriers of two REV1 SNPs (rs6761391 and rs3792142) had significantly more often large tumours and tumours with high histological grade and stage.
|
21455670 |
2011 |
|
Malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our findings suggested that genetic variants in POLκ and PCNA genes may play roles in the susceptibility of lung cancer, and REV1 gene may have roles in lung cancer survival in Chinese men.
|
24012694 |
2013 |
|
Carcinoma of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our findings suggested that genetic variants in POLκ and PCNA genes may play roles in the susceptibility of lung cancer, and REV1 gene may have roles in lung cancer survival in Chinese men.
|
24012694 |
2013 |
|
Primary malignant neoplasm of lung
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our findings suggested that genetic variants in POLκ and PCNA genes may play roles in the susceptibility of lung cancer, and REV1 gene may have roles in lung cancer survival in Chinese men.
|
24012694 |
2013 |