|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MDR1 polymorphisms are associated with both CD and UC with a stronger association with UC.
|
23537364 |
2013 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Two polymorphisms (C3435T and G2677T/A) of the multidrug resistance 1 gene have been correlated with the altered P-glycoprotein expression and function in humans, and associated with predisposition to ulcerative colitis and Crohn's disease.
|
16305727 |
2005 |
|
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Both children and adults had decreased multidrug resistance protein 1 expression in colon, which inversely correlated with disease score, IL-6 and interferon-γ levels in UC-New children.
|
27622899 |
2017 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
While, no remarkable relationship is observed between ABCB1 C3435T polymorphisms and UC.
|
25755800 |
2015 |
|
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
LHGDN |
We investigated whether common MDR1 variants were associated with UC in the genetically heterogeneous North Indian population.
|
19005421 |
2009 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This 'candidate gene' approach provides compelling evidence to support the contribution of the ABCB1/MDR1 gene in determining risk to UC but not to CD and provides new insights into the localization of the critical susceptibility determinants within the gene.
|
16434479 |
2006 |
|
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results suggest that MDR1 is a potential target for therapy in refractory CD patients and in patients with UC.
|
15505619 |
2004 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, considering our results and those from others, the MDR1 gene behaves as a common risk factor for both CD and UC.
|
16374256 |
2006 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Because the MDR1 single nucleotide polymorphism C3435T is associated with lower intestinal P-glycoprotein expression, we tested whether this polymorphism predisposes to development of ulcerative colitis.
|
12512026 |
2003 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
ABCB1 1236C>T polymorphism significantly affects the therapeutic efficacy of tarcolimus at 12 weeks under the tight dose-adjusting treatment for ulcerative colitis.
|
28135009 |
2017 |
|
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
LHGDN |
This 'candidate gene' approach provides compelling evidence to support the contribution of the ABCB1/MDR1 gene in determining risk to UC but not to CD and provides new insights into the localization of the critical susceptibility determinants within the gene.
|
16434479 |
2006 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that ABCB1 sequence variants are associated with a small increase in the risk of developing UC and may influence disease behavior.
|
16633048 |
2006 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In patients with extensive UC a significantly different distribution of genotypes of the MDR1 G/A change located in intron 3 (rs3789243) was observed between carriers/noncarriers of the -25385T risk allele (P = 0.005).
|
17828778 |
2007 |
|
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cytokine-mediated downregulation of the major human efflux transporter ABCB1 in inflamed intestine of UC patients is presumably dependent on disease activity, with a possible contribution from IL8.
|
19958093 |
2009 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
MDR1 C3435T polymorphism is predictive of later onset of ulcerative colitis in Japanese.
|
16462040 |
2006 |
|
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The amounts of MDR1 mRNA in PBMCs of UC patients having experienced GC therapy significantly correlated with the total dose of GCs administered (p = 0.0175).
|
15102868 |
2004 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Because the MDR1 single nucleotide polymorphism C3435T is associated with lower intestinal P-glycoprotein expression, we tested whether this polymorphism predisposes to development of ulcerative colitis.
|
12512026 |
2003 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Besides, stratified analysis by clinical type also indicated that no significant association between MDR1 C3435T and the risk of Crohn's disease and ulcerative colitis was observed.
|
24449364 |
2014 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
With the genotype/phenotype analysis, no correlation in patients with UC with the MDR1 gene was found.
|
17255827 |
2007 |
|
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MDR1 mRNA levels in uninflamed colon of UC patients were comparable to healthy controls, while they were slightly decreased in ileum and slightly increased in colon of CD patients.
|
17262809 |
2007 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The polymorphism located in intron 3 of the MDR1 gene showed a weak association with CD, and a marginally suggestive association with UC.
|
18819034 |
2009 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scottish white cohort (335 with ulcerative colitis [UC], 268 with Crohn's disease [CD], and 370 healthy controls).
|
15685540 |
2005 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The current study suggests that CYP2D6*4 and MDR1 3435 C/T gene polymorphisms may be risk factors for UC susceptibility.
|
30551694 |
2018 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The correlations between SNPs of CTLA-4 gene, MDR1 gene and the risk of UC were evaluated by OR at 95%CI.
|
26379408 |
2015 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MDR1 C3435T polymorphism is predictive of later onset of ulcerative colitis in Japanese.
|
16462040 |
2006 |