Disease: Ulcerative Colitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 Biomarker disease GENOMICS_ENGLAND
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 AlteredExpression disease BEFREE Our findings suggest that the increase in P-glycoprotein expression from normal to inflamed and dysplastic areas reflects the premalignant nature of ulcerative colitis and occurs early in the course of the disease. 1353719 1992
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 AlteredExpression disease BEFREE Differences in P-glycoprotein-170 expression and activity between Crohn's disease and ulcerative colitis. 10439313 1999
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease LHGDN Because the MDR1 single nucleotide polymorphism C3435T is associated with lower intestinal P-glycoprotein expression, we tested whether this polymorphism predisposes to development of ulcerative colitis. 12512026 2003
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease BEFREE Because the MDR1 single nucleotide polymorphism C3435T is associated with lower intestinal P-glycoprotein expression, we tested whether this polymorphism predisposes to development of ulcerative colitis. 12512026 2003
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 Biomarker disease BEFREE Our results suggest that MDR1 is a potential target for therapy in refractory CD patients and in patients with UC. 15505619 2004
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 AlteredExpression disease BEFREE The amounts of MDR1 mRNA in PBMCs of UC patients having experienced GC therapy significantly correlated with the total dose of GCs administered (p = 0.0175). 15102868 2004
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 AlteredExpression disease LHGDN The amounts of MDR1 mRNA in PBMCs of UC patients having experienced GC therapy significantly correlated with the total dose of GCs administered (p = 0.0175). 15102868 2004
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 AlteredExpression disease BEFREE Messenger RNA expression of ABCB1 (MDR1) and PXR was significantly reduced in the colon of patients with UC but was unaffected in patients with Crohn's disease. 15236169 2004
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease BEFREE Two polymorphisms (C3435T and G2677T/A) of the multidrug resistance 1 gene have been correlated with the altered P-glycoprotein expression and function in humans, and associated with predisposition to ulcerative colitis and Crohn's disease. 16305727 2005
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease BEFREE This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scottish white cohort (335 with ulcerative colitis [UC], 268 with Crohn's disease [CD], and 370 healthy controls). 15685540 2005
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease LHGDN This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scottish white cohort (335 with ulcerative colitis [UC], 268 with Crohn's disease [CD], and 370 healthy controls). 15685540 2005
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease BEFREE This 'candidate gene' approach provides compelling evidence to support the contribution of the ABCB1/MDR1 gene in determining risk to UC but not to CD and provides new insights into the localization of the critical susceptibility determinants within the gene. 16434479 2006
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease BEFREE Therefore, considering our results and those from others, the MDR1 gene behaves as a common risk factor for both CD and UC. 16374256 2006
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 Biomarker disease LHGDN This 'candidate gene' approach provides compelling evidence to support the contribution of the ABCB1/MDR1 gene in determining risk to UC but not to CD and provides new insights into the localization of the critical susceptibility determinants within the gene. 16434479 2006
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease BEFREE These results indicate that ABCB1 sequence variants are associated with a small increase in the risk of developing UC and may influence disease behavior. 16633048 2006
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease LHGDN MDR1 C3435T polymorphism is predictive of later onset of ulcerative colitis in Japanese. 16462040 2006
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease BEFREE MDR1 C3435T polymorphism is predictive of later onset of ulcerative colitis in Japanese. 16462040 2006
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease LHGDN Therefore, considering our results and those from others, the MDR1 gene behaves as a common risk factor for both CD and UC. 16374256 2006
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease LHGDN Multidrug resistance 1 gene in inflammatory bowel disease: a meta-analysis. 16773678 2006
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease BEFREE In patients with extensive UC a significantly different distribution of genotypes of the MDR1 G/A change located in intron 3 (rs3789243) was observed between carriers/noncarriers of the -25385T risk allele (P = 0.005). 17828778 2007
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease BEFREE With the genotype/phenotype analysis, no correlation in patients with UC with the MDR1 gene was found. 17255827 2007
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 AlteredExpression disease BEFREE MDR1 mRNA levels in uninflamed colon of UC patients were comparable to healthy controls, while they were slightly decreased in ileum and slightly increased in colon of CD patients. 17262809 2007
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease BEFREE A total of 211 patients with Crohn's disease (CD), 97 patients with ulcerative colitis (UC), and 212 control subjects were investigated for the presence of MDR1 G2677T/A and C3435T polymorphisms. 17260353 2007
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.400 GeneticVariation disease BEFREE The TT genotype of exon 21 MDR1 polymorphisms is associated with a higher risk of CsA failure in patients with steroid resistant UC. 17206635 2007