|
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MDR1 C3435T polymorphism is predictive of later onset of ulcerative colitis in Japanese.
|
16462040 |
2006 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
MDR1 C3435T polymorphism is predictive of later onset of ulcerative colitis in Japanese.
|
16462040 |
2006 |
|
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MDR1 mRNA levels in uninflamed colon of UC patients were comparable to healthy controls, while they were slightly decreased in ileum and slightly increased in colon of CD patients.
|
17262809 |
2007 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
ABCB1 single-nucleotide polymorphisms determine tacrolimus response in patients with ulcerative colitis.
|
21289623 |
2011 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MDR1 polymorphisms are associated with both CD and UC with a stronger association with UC.
|
23537364 |
2013 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
ABCB1 1236C>T polymorphism significantly affects the therapeutic efficacy of tarcolimus at 12 weeks under the tight dose-adjusting treatment for ulcerative colitis.
|
28135009 |
2017 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MDR1 gene variants and haplotypes were associated with UC in Serbian IBD patients, further supporting their potential role in susceptibility to UC.
|
29543864 |
2018 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A total of 211 patients with Crohn's disease (CD), 97 patients with ulcerative colitis (UC), and 212 control subjects were investigated for the presence of MDR1 G2677T/A and C3435T polymorphisms.
|
17260353 |
2007 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Because the MDR1 single nucleotide polymorphism C3435T is associated with lower intestinal P-glycoprotein expression, we tested whether this polymorphism predisposes to development of ulcerative colitis.
|
12512026 |
2003 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Because the MDR1 single nucleotide polymorphism C3435T is associated with lower intestinal P-glycoprotein expression, we tested whether this polymorphism predisposes to development of ulcerative colitis.
|
12512026 |
2003 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Besides, stratified analysis by clinical type also indicated that no significant association between MDR1 C3435T and the risk of Crohn's disease and ulcerative colitis was observed.
|
24449364 |
2014 |
|
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Both children and adults had decreased multidrug resistance protein 1 expression in colon, which inversely correlated with disease score, IL-6 and interferon-γ levels in UC-New children.
|
27622899 |
2017 |
|
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cytokine-mediated downregulation of the major human efflux transporter ABCB1 in inflamed intestine of UC patients is presumably dependent on disease activity, with a possible contribution from IL8.
|
19958093 |
2009 |
|
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Differences in P-glycoprotein-170 expression and activity between Crohn's disease and ulcerative colitis.
|
10439313 |
1999 |
|
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of both efflux transporters BCRP and MDR1 is reduced, but only in inflamed tissue of patients with active UC.
|
19052456 |
2008 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Finally, active UC in patients carrying the TLR2-R753Q and MDR1-C3435T polymorphisms was associated with increased nuclear expression of caspase-1 protein and cell death in areas of acute inflammation, compared with active UC patients without these variants.
|
23636052 |
2013 |
|
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we found that protein expression of ABCB1 (ATP Binding Cassette Subfamily B Member 1) / MDR1 (multidrug resistance 1) was diminished in the intestinal mucosa of patients with active UC with or without CAC, but not in non-UC patients with sporadic colon cancer.
|
28686677 |
2017 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In patients with extensive UC a significantly different distribution of genotypes of the MDR1 G/A change located in intron 3 (rs3789243) was observed between carriers/noncarriers of the -25385T risk allele (P = 0.005).
|
17828778 |
2007 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
In patients with extensive UC a significantly different distribution of genotypes of the MDR1 G/A change located in intron 3 (rs3789243) was observed between carriers/noncarriers of the -25385T risk allele (P = 0.005).
|
17828778 |
2007 |
|
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Messenger RNA expression of ABCB1 (MDR1) and PXR was significantly reduced in the colon of patients with UC but was unaffected in patients with Crohn's disease.
|
15236169 |
2004 |
|
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Multidrug resistance 1 gene in inflammatory bowel disease: a meta-analysis.
|
16773678 |
2006 |
|
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that the increase in P-glycoprotein expression from normal to inflamed and dysplastic areas reflects the premalignant nature of ulcerative colitis and occurs early in the course of the disease.
|
1353719 |
1992 |
|
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results suggest that MDR1 is a potential target for therapy in refractory CD patients and in patients with UC.
|
15505619 |
2004 |
|
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The amounts of MDR1 mRNA in PBMCs of UC patients having experienced GC therapy significantly correlated with the total dose of GCs administered (p = 0.0175).
|
15102868 |
2004 |