Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that the increase in P-glycoprotein expression from normal to inflamed and dysplastic areas reflects the premalignant nature of ulcerative colitis and occurs early in the course of the disease.
|
1353719 |
1992 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Differences in P-glycoprotein-170 expression and activity between Crohn's disease and ulcerative colitis.
|
10439313 |
1999 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Because the MDR1 single nucleotide polymorphism C3435T is associated with lower intestinal P-glycoprotein expression, we tested whether this polymorphism predisposes to development of ulcerative colitis.
|
12512026 |
2003 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Because the MDR1 single nucleotide polymorphism C3435T is associated with lower intestinal P-glycoprotein expression, we tested whether this polymorphism predisposes to development of ulcerative colitis.
|
12512026 |
2003 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The amounts of MDR1 mRNA in PBMCs of UC patients having experienced GC therapy significantly correlated with the total dose of GCs administered (p = 0.0175).
|
15102868 |
2004 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
The amounts of MDR1 mRNA in PBMCs of UC patients having experienced GC therapy significantly correlated with the total dose of GCs administered (p = 0.0175).
|
15102868 |
2004 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Messenger RNA expression of ABCB1 (MDR1) and PXR was significantly reduced in the colon of patients with UC but was unaffected in patients with Crohn's disease.
|
15236169 |
2004 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results suggest that MDR1 is a potential target for therapy in refractory CD patients and in patients with UC.
|
15505619 |
2004 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scottish white cohort (335 with ulcerative colitis [UC], 268 with Crohn's disease [CD], and 370 healthy controls).
|
15685540 |
2005 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
This was a case-control analysis of MDR1 C3435T and G2677T SNPs in a large well-characterized Scottish white cohort (335 with ulcerative colitis [UC], 268 with Crohn's disease [CD], and 370 healthy controls).
|
15685540 |
2005 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Two polymorphisms (C3435T and G2677T/A) of the multidrug resistance 1 gene have been correlated with the altered P-glycoprotein expression and function in humans, and associated with predisposition to ulcerative colitis and Crohn's disease.
|
16305727 |
2005 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, considering our results and those from others, the MDR1 gene behaves as a common risk factor for both CD and UC.
|
16374256 |
2006 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Therefore, considering our results and those from others, the MDR1 gene behaves as a common risk factor for both CD and UC.
|
16374256 |
2006 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This 'candidate gene' approach provides compelling evidence to support the contribution of the ABCB1/MDR1 gene in determining risk to UC but not to CD and provides new insights into the localization of the critical susceptibility determinants within the gene.
|
16434479 |
2006 |
Ulcerative Colitis
|
0.400 |
Biomarker
|
disease |
LHGDN |
This 'candidate gene' approach provides compelling evidence to support the contribution of the ABCB1/MDR1 gene in determining risk to UC but not to CD and provides new insights into the localization of the critical susceptibility determinants within the gene.
|
16434479 |
2006 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
MDR1 C3435T polymorphism is predictive of later onset of ulcerative colitis in Japanese.
|
16462040 |
2006 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MDR1 C3435T polymorphism is predictive of later onset of ulcerative colitis in Japanese.
|
16462040 |
2006 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that ABCB1 sequence variants are associated with a small increase in the risk of developing UC and may influence disease behavior.
|
16633048 |
2006 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Multidrug resistance 1 gene in inflammatory bowel disease: a meta-analysis.
|
16773678 |
2006 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The TT genotype of exon 21 MDR1 polymorphisms is associated with a higher risk of CsA failure in patients with steroid resistant UC.
|
17206635 |
2007 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We tried to determine the frequency of C3435T polymorphism of the MDR1 gene in Iranian patients with ulcerative colitis and to compare it with a healthy control population.
|
17242936 |
2007 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
With the genotype/phenotype analysis, no correlation in patients with UC with the MDR1 gene was found.
|
17255827 |
2007 |
Ulcerative Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A total of 211 patients with Crohn's disease (CD), 97 patients with ulcerative colitis (UC), and 212 control subjects were investigated for the presence of MDR1 G2677T/A and C3435T polymorphisms.
|
17260353 |
2007 |
Ulcerative Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MDR1 mRNA levels in uninflamed colon of UC patients were comparable to healthy controls, while they were slightly decreased in ileum and slightly increased in colon of CD patients.
|
17262809 |
2007 |