|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Further study revealed an association between PLA2 groups XIIA (PLA2G12A) polymorphism and patients with schizophrenia in a northeast Chinese Han population.
|
29527719 |
2018 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These data indicate that variants of PLA2 encoding genes are plausible candidates for increasing the susceptibility for schizophrenia.
|
17629734 |
2007 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There were no significant case-control differences, therefore his study does not support an association between schizophrenia and a PLA2G1B polymorphism on chromosome 12.
|
10551547 |
1999 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to explore the association between single nucleotide polymorphisms (SNPs) in the phospholipase A2 (PLA2), group XIIA gene (PLA2G12A) and schizophrenia.
|
27434078 |
2016 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A recent report indicated that there was an association between schizophrenia and alleles of a poly-A repeat polymorphism close to the 5' end of the PLA2 gene.
|
9323323 |
1997 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the allele and genotype frequency of the rs4375 and rs1549637 polymorphisms in phospholipase A2 (PLA2)G6 and PLA2G4C genes in 203 patients with schizophrenia and 191 controls in a Croatian population.
|
28651698 |
2017 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No association was found between schizophrenia and alleles of the polymorphism near the phospholipase-A2 gene or between fatty acid concentrations and the presence of any particular alleles.
|
9689723 |
1998 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the relationship between the rs10798059 (BanI) and rs4375 polymorphisms in the phospholipase A2 (PLA2)G4A and PLA2G6 genes and the risk of nicotine dependence in 263 Croatian patients with schizophrenia.
|
31492433 |
2019 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Phospholipase A(2) (PLA2) is a key enzyme of the phospholipid metabolism which shows alteration in schizophrenia.
|
12759552 |
2003 |
|
Bipolar Disorder
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
Association study of bipolar disorder at the phospholipase A2 gene (PLA2A) in the Darier's disease (DAR) region of chromosome 12q23-q24.1.
|
9149325 |
1996 |
|
Bipolar Disorder
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
Our results failed to demonstrate that the studied PLA2 polymorphisms were associated with an increased risk for BPAD in our sample.
|
12895207 |
2003 |
|
Bipolar Disorder
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
On the basis of these results, mutations of the phospholipase A2 gene, at least in the region close to the polymorphism examined between exons 1 and 2, are not involved in the pathogenesis of bipolar mood disorder.
|
16829784 |
2006 |
|
Bipolar Disorder
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
We have found evidence of an allelic association between bipolar disorder and a marker at the pancreatic phospholipase A2 gene (PLA2A) in this region (p < or = 0.01).
|
8750360 |
1995 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We were unable to find statistical interaction between either the pancreatic PLA(2) or Gbeta3 genes and the apolipoprotein E gene on risk for AD.
|
10490699 |
1999 |
|
Alzheimer's Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Study of association between genetic polymorphisms of phospholipase A2 enzymes and Alzheimer's disease.
|
20464283 |
2010 |
|
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The coexistence of both 807 T and PlA2 alleles increased the arterial thrombosis risk in patients with APS and preclinical arteriosclerosis in patients with SLE.
|
17728329 |
2008 |
|
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The findings of this study suggest that Pl(A1/A1) homozygotes may be prone to early atherosclerosis and more rapid progression of stable CAD whereas carriers of the PlA2 allele are more prone to thrombotic complications.
|
11257275 |
2001 |
|
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We aimed to explore the effect of PlA2 polymorphism on outcome in patients with atherosclerosis.
|
20846430 |
2010 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The findings of this study suggest that Pl(A1/A1) homozygotes may be prone to early atherosclerosis and more rapid progression of stable CAD whereas carriers of the PlA2 allele are more prone to thrombotic complications.
|
11257275 |
2001 |
|
Atherosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We aimed to explore the effect of PlA2 polymorphism on outcome in patients with atherosclerosis.
|
20846430 |
2010 |
|
Coronary Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Higher prevalence of GPIIIa PlA2 polymorphism in siblings of patients with premature coronary heart disease.
|
10583927 |
1999 |
|
Coronary Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the PLA1/PLA2 polymorphism of the platelet glycoprotein IIIa gene does not substantially contribute to the development of coronary atherosclerosis or the genetic susceptibility to premature myocardial infarction.
|
14614355 |
2003 |
|
Coronary Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Conflicting results of an association of the human platelet antigen 1b (HPA-1b/PlA2), localized on the beta-subunit of the integrin alpha(IIb)beta3, and the alpha(2)807TT genotype of the integrin alpha2beta1 with coronary atherosclerosis and myocardial infarction have been reported.
|
15978110 |
2005 |
|
Coronary Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
PlA(2) polymorphism was not associated with an increased prevalence of coronary artery disease, (OR [95% CI] = 1.07 [0.95-1.21], p = 0.28, pheterogeneity = 0.39).
|
25167197 |
2015 |
|
Coronary Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recent studies suggest a controversial association between a genetic polymorphism of the glycoprotein IIIa gene (PlA2) and the risk of coronary artery disease.
|
9657436 |
1998 |