PLA2G1B, phospholipase A2 group IB, 5319

N. diseases: 268; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.010 GeneticVariation disease BEFREE Carriers of the PlA2 allele had a significantly higher risk of developing ACS, even after an adjustment to the risk factors (OR 5.74; 95% CI 1.75 to 18.8; p = 0.004). 15840736 2005
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome 		0.030 GeneticVariation disease BEFREE It has recently been reported that the PlA2 variant may be strongly associated with the risk of acute coronary syndromes, particularly in younger subjects. 9093541 1997
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome 		0.030 GeneticVariation disease BEFREE To investigate the relation between the PlA2 polymorphism and acute coronary syndromes, we conducted a case-control study of 71 case patients with myocardial infarction or unstable angina and 68 inpatient controls without known heart disease. 8598867 1996
CUI: C0948089
Disease: Acute Coronary Syndrome
Acute Coronary Syndrome 		0.030 GeneticVariation disease BEFREE The GP IIIa gene is polymorphic (PlA1/PlA2) and the presence of a PlA2 allele might be associated with an increased risk for acute coronary syndrome (ACS). 15840736 2005
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.010 GeneticVariation disease BEFREE In a small case-control study, evidence has been presented that the PlA2 allele of the platelet glycoprotein GPIIIa PlA/A2 gene polymorphism might be an independent risk factor for acute myocardial infarction (MI). 9716139 1998
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.010 Biomarker group BEFREE Group II PLA2 determined by a specific radioimmunoassay was constitutively produced in culture supernatant of KATO III (signet ring cell carcinoma) and MKN28 (well differentiated adenocarcinoma). 8117291 1994
CUI: C0338106
Disease: Adenocarcinoma of colon
Adenocarcinoma of colon 		0.010 AlteredExpression disease BEFREE Cytoplasmic phospholipase A2 expression in human colon adenocarcinoma is correlated with cyclooxygenase-2 expression and contributes to prostaglandin E2 production. 16458424 2006
CUI: C0279628
Disease: Adenocarcinoma Of Esophagus
Adenocarcinoma Of Esophagus 		0.010 AlteredExpression disease BEFREE Secretory phospholipase A2 inhibition attenuates intercellular adhesion molecule-1 expression in human esophageal adenocarcinoma cells. 21396625 2011
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.010 Biomarker disease BEFREE Inhibition of secretory phospholipase A2 IIa attenuates prostaglandin E2-induced invasiveness in lung adenocarcinoma. 30684134 2019
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine 		0.010 Biomarker disease BEFREE Overexpression of the nonpancreatic secretory group II PLA2 messenger RNA and protein in colorectal adenomas from familial adenomatous polyposis patients. 9458096 1998
CUI: C0311361
Disease: Adenomatous goiter
Adenomatous goiter 		0.010 AlteredExpression disease BEFREE PAF, lyso-PAF, PLA2 and AHA levels remained unchanged in diseased tissues of patients with a hyperplastic goitre, a benign adenoma and a papillary thyroid carcinoma. 15994743 2005
CUI: C0032580
Disease: Adenomatous Polyposis Coli
Adenomatous Polyposis Coli 		0.050 GeneticVariation disease BEFREE Secretory phospholipase A2 does not appear to be associated with phenotypic variation in familial adenomatous polyposis. 8707313 1996
CUI: C0032580
Disease: Adenomatous Polyposis Coli
Adenomatous Polyposis Coli 		0.050 GeneticVariation disease BEFREE PLAP was considered a potential candidate to be involved in malignant melanoma because it maps to the critical region for CMM and because the PLA2 gene has been identified as a modifier of the APC gene, responsible for the adenomatous polyposis phenotype in the mouse. 10571045 1999
CUI: C0032580
Disease: Adenomatous Polyposis Coli
Adenomatous Polyposis Coli 		0.050 Biomarker disease BEFREE Overexpression of the nonpancreatic secretory group II PLA2 messenger RNA and protein in colorectal adenomas from familial adenomatous polyposis patients. 9458096 1998
CUI: C0032580
Disease: Adenomatous Polyposis Coli
Adenomatous Polyposis Coli 		0.050 GeneticVariation disease BEFREE Mutation of Pla2g2a, a secretory phospholipase A(2) gene, dramatically increases the number of intestinal polyps that develop in the multiple intestinal neoplasia (Min) mouse, a murine model for adenomatous polyposis coli in humans. 8640784 1996
CUI: C0032580
Disease: Adenomatous Polyposis Coli
Adenomatous Polyposis Coli 		0.050 GeneticVariation disease BEFREE We have analysed the human secretory phospholipase A2 locus (PLA2G2A) for variants that could directly influence the FAP phenotype. 8912789 1996
CUI: C0001486
Disease: Adenovirus Infections
Adenovirus Infections 		0.010 Biomarker group BEFREE Here, we show that human group III sPLA(2), which is structurally more similar to bee venom PLA(2) than to other mammalian sPLA(2)s, also has the capacity to inhibit adenovirus infection into host cells. 17980167 2007
CUI: C0278877
Disease: Adult Meningioma
Adult Meningioma 		0.010 Biomarker disease BEFREE Real-time PCR was used to investigate PLA(2) transcripts in 26 human meningioma tumors. 20339511 2009
CUI: C3826758
Disease: AIDS (Disease)
AIDS (Disease) 		0.010 GeneticVariation disease BEFREE To evaluate the impact of PLA2 gene polymorphisms on AIDS disease development, we studied 12 family members using SNPlextrade mark technology that permitted simultaneous typing of 70 tagging Single Nucleotide Polymorphisms (tagSNPs). 18096355 2008
CUI: C0155877
Disease: Allergic asthma
Allergic asthma 		0.010 AlteredExpression disease BEFREE Induction of group IVC phospholipase A2 in allergic asthma: transcriptional regulation by TNFα in bronchoepithelial cells. 22082005 2012
CUI: C1260881
Disease: Allergic bronchitis
Allergic bronchitis 		0.010 Biomarker disease BEFREE Phospholipase A2 in experimental allergic bronchitis: a lesson from mouse and rat models. 24204651 2013
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.100 GeneticVariation disease BEFREE We were unable to find statistical interaction between either the pancreatic PLA(2) or Gbeta3 genes and the apolipoprotein E gene on risk for AD. 10490699 1999
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.100 Biomarker disease BEFREE To examine the effects of bvPLA2 on AD, bvPLA2 was administered to 3xTg-AD mice, mouse model of Alzheimer's disease. 26772975 2016
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.100 Biomarker disease BEFREE Inhibition of GIVA-PLA(2) may be beneficial in the treatment and prevention of Alzheimer's disease. 18931664 2008
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.100 Biomarker disease BEFREE This review addresses some current ideas concerning how brain PLA2 and brain PGs are early and key players in acute neural trauma and in brain-cell damage associated with chronic neurodegenerative diseases such as AD. 12432919 2002