|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, a meta-analysis of the relationship between PLA2 and schizophrenia was conducted.
|
31207866 |
2019 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the relationship between the rs10798059 (BanI) and rs4375 polymorphisms in the phospholipase A2 (PLA2)G4A and PLA2G6 genes and the risk of nicotine dependence in 263 Croatian patients with schizophrenia.
|
31492433 |
2019 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Further study revealed an association between PLA2 groups XIIA (PLA2G12A) polymorphism and patients with schizophrenia in a northeast Chinese Han population.
|
29527719 |
2018 |
|
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We support the notion that bluntness in niacin skin test might reflect abnormalities in membrane fatty acid composition, which could be induced by increased PLA2 enzyme activity, in vivo oxidative stress or lipid metabolism imbalance in SZ.
|
29077970 |
2018 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated the allele and genotype frequency of the rs4375 and rs1549637 polymorphisms in phospholipase A2 (PLA2)G6 and PLA2G4C genes in 203 patients with schizophrenia and 191 controls in a Croatian population.
|
28651698 |
2017 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to explore the association between single nucleotide polymorphisms (SNPs) in the phospholipase A2 (PLA2), group XIIA gene (PLA2G12A) and schizophrenia.
|
27434078 |
2016 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These data indicate that variants of PLA2 encoding genes are plausible candidates for increasing the susceptibility for schizophrenia.
|
17629734 |
2007 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
These data indicate that variants of PLA2 encoding genes are plausible candidates for increasing the susceptibility for schizophrenia.
|
17629734 |
2007 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The phospholipid hypothesis of schizophrenia is becoming popular because of the findings from the niacin flush test, the treatment with polyunsaturated fatty acids (PUFAs), biochemical studies for the phospholipid metabolism pathway and genetic studies of phospholipase A2.
|
17720317 |
2007 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Cytosolic PLA2 genes possibly contribute to the etiology of schizophrenia.
|
15999343 |
2005 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cytosolic PLA2 genes possibly contribute to the etiology of schizophrenia.
|
15999343 |
2005 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
They were then applied as genetic markers to test the genetic association of these two calcium-independent cytosolic PLA2 genes with schizophrenia.
|
16115752 |
2005 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Allelic association analysis of phospholipase A2 genes with schizophrenia.
|
15318030 |
2004 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Allelic association analysis of phospholipase A2 genes with schizophrenia.
|
15318030 |
2004 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Phospholipase A(2) (PLA2) is a key enzyme of the phospholipid metabolism which shows alteration in schizophrenia.
|
12759552 |
2003 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results do not provide support for the phospholipase-A(2) hypothesis of schizophrenia.
|
11353443 |
2001 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There were no significant case-control differences, therefore his study does not support an association between schizophrenia and a PLA2G1B polymorphism on chromosome 12.
|
10551547 |
1999 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No association was found between schizophrenia and alleles of the polymorphism near the phospholipase-A2 gene or between fatty acid concentrations and the presence of any particular alleles.
|
9689723 |
1998 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A recent report indicated that there was an association between schizophrenia and alleles of a poly-A repeat polymorphism close to the 5' end of the PLA2 gene.
|
9323323 |
1997 |
|
Bipolar Disorder
|
0.350 |
Biomarker
|
disease |
PSYGENET |
On the basis of these results, mutations of the phospholipase A2 gene, at least in the region close to the polymorphism examined between exons 1 and 2, are not involved in the pathogenesis of bipolar mood disorder.
|
16829784 |
2006 |
|
Bipolar Disorder
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
On the basis of these results, mutations of the phospholipase A2 gene, at least in the region close to the polymorphism examined between exons 1 and 2, are not involved in the pathogenesis of bipolar mood disorder.
|
16829784 |
2006 |
|
Bipolar Disorder
|
0.350 |
Biomarker
|
disease |
BEFREE |
The co-segregation in one pedigree of bipolar affective disorder with Darier's disease whose gene is on chromosome 12q23-q24.1, and findings from linkage and association studies with the neighbouring gene of phospholipase A2 (PLA2) indicate that PLA2 may be considered as a candidate gene for affective disorders.
|
14639048 |
2003 |
|
Bipolar Disorder
|
0.350 |
GeneticVariation
|
disease |
BEFREE |
Our results failed to demonstrate that the studied PLA2 polymorphisms were associated with an increased risk for BPAD in our sample.
|
12895207 |
2003 |
|
Bipolar Disorder
|
0.350 |
Biomarker
|
disease |
PSYGENET |
The co-segregation in one pedigree of bipolar affective disorder with Darier's disease whose gene is on chromosome 12q23-q24.1, and findings from linkage and association studies with the neighbouring gene of phospholipase A2 (PLA2) indicate that PLA2 may be considered as a candidate gene for affective disorders.
|
14639048 |
2003 |
|
Bipolar Disorder
|
0.350 |
Biomarker
|
disease |
PSYGENET |
Our results failed to demonstrate that the studied PLA2 polymorphisms were associated with an increased risk for BPAD in our sample.
|
12895207 |
2003 |