PLA2G1B, phospholipase A2 group IB, 5319

N. diseases: 268; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023520
Disease: Leukodystrophy
Leukodystrophy 		0.010 GeneticVariation disease BEFREE (1) Leukodystrophy and/or iron deposits in basal ganglia is a common feature of phospholipase A2 deficiency, fatty acid hydroxylase deficiency, and pantothenate kinase-associated neurodegeneration. 22814679 2013
CUI: C0023418
Disease: leukemia
leukemia 		0.010 Biomarker disease BEFREE 1.The aim of the present study was to explore the effect of the Naja nigricollis phospholipase A(2) CMS-9 on adaphostin-induced death of human leukaemia U937 cells.2. 21824174 2011
CUI: C0011847
Disease: Diabetes
Diabetes 		0.030 Biomarker disease BEFREE Diabetes-induced oxidative stress is mediated by Ca2+-independent phospholipase A2 in neutrophils. 20053941 2010
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.030 Biomarker group BEFREE Diabetes-induced oxidative stress is mediated by Ca2+-independent phospholipase A2 in neutrophils. 20053941 2010
CUI: C2931845
Disease: Neurodegeneration with brain iron accumulation (NBIA)
Neurodegeneration with brain iron accumulation (NBIA) 		0.070 GeneticVariation disease BEFREE Neurodegeneration with brain iron accumulation (NBIA) involves several genetic disorders, two of which, aceruloplasminemia and neuroferritinopathy, are caused by mutations in genes directly involved in iron metabolic pathway, and others, such as pantothenate-kinase 2, phospholipase-A2 and fatty acid 2-hydroxylase associated neurodegeneration, are caused by mutations in genes coding for proteins involved in phospholipid metabolism. 22266337 2012
CUI: C0270724
Disease: Infantile Neuroaxonal Dystrophy
Infantile Neuroaxonal Dystrophy 		0.060 GeneticVariation disease BEFREE Infantile neuroaxonal dystrophy (INAD) is a rare autosomal recessive neurodegenerative disorder caused by mutations in the phospholipase A2 group 6 (Pla2G6) gene. 24628589 2014
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE Cancer stem cell phenotype is supported by secretory phospholipase A2 in human lung cancer cells. 24928671 2014
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.090 Biomarker group BEFREE Cancer stem cell phenotype is supported by secretory phospholipase A2 in human lung cancer cells. 24928671 2014
CUI: C0017665
Disease: Membranous glomerulonephritis
Membranous glomerulonephritis 		0.100 Biomarker disease BEFREE Membranous glomerulopathy (MG) is most commonly caused by autoantibodies directed against the podocyte phospholipase A2 receptor (PLA2R1) and common variants in this gene are associated with MG. 25187357 2014
CUI: C0004623
Disease: Bacterial Infections
Bacterial Infections 		0.030 AlteredExpression group BEFREE Bacterial infection increased the expression of PLA2, and the highest degree of up-regulation appeared in the fat body. 27646139 2017
CUI: C0086445
Disease: Idiopathic Membranous Glomerulonephritis
Idiopathic Membranous Glomerulonephritis 		0.100 Biomarker disease BEFREE Idiopathic membranous nephropathy (IMN) has recently attracted much attention due to the development of auto antibodies, anti-phospholipase A2 receptor and anti-thrombospondin type I domain-containing 7A on podocytes, the establishment of immune networks complexes in circulation as well as the development of autoreactive immune cells against kidney, in both innate and adaptive participants. 31610191 2019
CUI: C3853779
Disease: Neonatal Alloimmune Thrombocytopenia
Neonatal Alloimmune Thrombocytopenia 		0.060 GeneticVariation disease BEFREE Neonatal thrombocytopenia in HLA-DR, -DQ, -DP-typed mother due to rare anti-HPA-1b (PLA2) (Zwb) fetomaternal immunization. 7975452 1994
CUI: C0221028
Disease: Neonatal thrombocytopenia (disorder)
Neonatal thrombocytopenia (disorder) 		0.010 GeneticVariation disease BEFREE Neonatal thrombocytopenia in HLA-DR, -DQ, -DP-typed mother due to rare anti-HPA-1b (PLA2) (Zwb) fetomaternal immunization. 7975452 1994
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.060 Biomarker disease BEFREE Crohn's disease and ulcerative colitis are idiopathic inflammatory bowel diseases (IBD) involving synthesis of eicosanoids from arachidonic acid (AA), which is released from membrane phospholipids by phospholipase A2 (PLA2). 9014769 1996
CUI: C3853779
Disease: Neonatal Alloimmune Thrombocytopenia
Neonatal Alloimmune Thrombocytopenia 		0.060 GeneticVariation disease BEFREE Neonatal alloimmune thrombocytopenia due to anti-HPA-1b (PLA2)(Zwb). A case report and review. 9691408 1998
CUI: C0010072
Disease: Coronary Thrombosis
Coronary Thrombosis 		0.040 GeneticVariation disease BEFREE Coronary thrombosis and the platelet glycoprotein IIIA gene PLA2 polymorphism. 9716140 1998
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.030 Biomarker group BEFREE Phospholipase A2 (PLA2) has been suggested to play an important role in the pathogenesis of inflammatory bowel diseases. 10086656 1999
CUI: C0267380
Disease: Crohn's disease of the ileum
Crohn's disease of the ileum 		0.020 Biomarker disease BEFREE PLA2-II protein and mRNA were found in the columnar epithelial cells of the small intestinal mucosa in six of eight and eight of eight patients with Crohn's ileitis, respectively. 10086656 1999
CUI: C0018213
Disease: Graves Disease
Graves Disease 		0.010 AlteredExpression disease BEFREE PLA2 activity, measured as arachidonic acid (AA) release, was determined in 32 patients with Graves' disease. 10487700 1999
CUI: C0042373
Disease: Vascular Diseases
Vascular Diseases 		0.020 Biomarker group BEFREE Phospholipase A(2) in vascular disease. 11509445 2001
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.400 GeneticVariation disease BEFREE Phospholipase A(2) (PLA2) is a key enzyme of the phospholipid metabolism which shows alteration in schizophrenia. 12759552 2003
CUI: C0856727
Disease: Cholesterol gallstones
Cholesterol gallstones 		0.020 Biomarker disease BEFREE Phospholipase A(2) IIA (PLA(2)IIA), which plays a crucial role in arachidonic acid metabolism and in inflammation, is upregulated under various pathological conditions, including in the gallbladder and gallbladder bile from patients with multiple cholesterol gallstones, in the liver and kidney of rats with cirrhosis, as well as in the colonic tissue of animals treated with a chemical carcinogen. 15793850 2005
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.010 Biomarker disease BEFREE Phospholipase A(2) IIA (PLA(2)IIA), which plays a crucial role in arachidonic acid metabolism and in inflammation, is upregulated under various pathological conditions, including in the gallbladder and gallbladder bile from patients with multiple cholesterol gallstones, in the liver and kidney of rats with cirrhosis, as well as in the colonic tissue of animals treated with a chemical carcinogen. 15793850 2005
CUI: C1623038
Disease: Cirrhosis
Cirrhosis 		0.010 Biomarker disease BEFREE Phospholipase A(2) IIA (PLA(2)IIA), which plays a crucial role in arachidonic acid metabolism and in inflammation, is upregulated under various pathological conditions, including in the gallbladder and gallbladder bile from patients with multiple cholesterol gallstones, in the liver and kidney of rats with cirrhosis, as well as in the colonic tissue of animals treated with a chemical carcinogen. 15793850 2005
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.030 Biomarker disease BEFREE Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease. 18931664 2008