|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
|
30239722 |
2019 |
|
Breast Carcinoma
|
0.130 |
Biomarker
|
disease |
BEFREE |
Multiple breast cancer survival related genes were found in this gene set, including FOXR2, FOXD1, MTNR1B and SDC1.
|
30454048 |
2018 |
|
Breast Carcinoma
|
0.130 |
AlteredExpression
|
disease |
BEFREE |
A whole genome screening of the survival related gene expression patterns in breast cancer was studied.
|
26576432 |
2015 |
|
Breast Carcinoma
|
0.130 |
Biomarker
|
disease |
BEFREE |
Estrogen receptor percent positive staining is not independently related to breast cancer survival after adjustment for other survival-related factors.
|
28825224 |
2017 |
|
Breast Carcinoma
|
0.130 |
GeneticVariation
|
disease |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Future work is needed to characterize the role of the CST complex in gliomagenesis and further elucidate the complex balance between ageing, telomere length, and molecular carcinogenesis.
|
26646793 |
2015 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Identification and characterization of survival-related gene, a novel cell survival gene controlling apoptosis and tumorigenesis.
|
16322216 |
2005 |
|
Carcinogenesis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
These findings provide insight into mechanisms by which CASZ1 regulates transcription, and suggests that regulation of CASZ1 subcellular localization may impact its function in normal development and pathologic conditions such as NB tumorigenesis.
|
27270431 |
2017 |
|
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
A number of population-based studies have demonstrated gender-based differences in clinical and pathologic factors, as well as in survival related to lung cancer.
|
19995649 |
2009 |
|
Cardiomyopathies, Primary
|
0.010 |
Biomarker
|
group |
BEFREE |
The current study reveals CASZ1 as a new gene responsible for human DCM, which provides novel mechanistic insight and potential therapeutic target for CASZ1-associated DCM, implying potential implications in improved prophylactic and therapeutic strategies for DCM, the most common type of primary myocardial disease.
|
28099117 |
2017 |
|
Cardiomyopathy, Dilated
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The zinc finger transcription factor CASZ1 plays a key role in cardiac development and postnatal adaptation, and in mice, deletion of the CASZ1 gene leads to dilated cardiomyopathy (DCM).
|
28099117 |
2017 |
|
Cardiomyopathy, Dilated
|
0.030 |
Biomarker
|
group |
BEFREE |
Formation of a TBX20-CASZ1 protein complex is protective against dilated cardiomyopathy and critical for cardiac homeostasis.
|
28945738 |
2017 |
|
Cardiomyopathy, Dilated
|
0.030 |
GeneticVariation
|
group |
BEFREE |
A novel de novo CASZ1 heterozygous frameshift variant causes dilated cardiomyopathy and left ventricular noncompaction cardiomyopathy.
|
31268246 |
2019 |
|
Cardiomyopathy, Familial Idiopathic
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We have identified a novel CASZ1 variant in a patient with combined DCM and LVNC for the first time, thus broadening the phenotypic spectrum of CASZ1 variants.
|
31268246 |
2019 |
|
Cardiomyopathy, Familial Idiopathic
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The coding exons and splicing junction sites of the CASZ1 gene were sequenced in 138 unrelated patients with idiopathic DCM.
|
28099117 |
2017 |
|
Cardiomyopathy, Familial Idiopathic
|
0.030 |
Biomarker
|
disease |
BEFREE |
Collectively, our proteomic, biochemical, genetic, and structural studies suggest that the physical interaction between TBX20 and CASZ1 is required for cardiac homeostasis, and further, that reduction or loss of this critical interaction leads to DCM.
|
28945738 |
2017 |
|
Cardiovascular Diseases
|
0.130 |
GeneticVariation
|
group |
BEFREE |
Cortistatin (CST), a newly discovered biological peptide, has been acknowledged for its protective effects against cardiovascular diseases.
|
31807542 |
2019 |
|
Cardiovascular Diseases
|
0.130 |
Biomarker
|
group |
BEFREE |
Therefore, we reviewed the cardiovascular effects of CST in the heart and blood vessels, which will help to understand the role of CST and its receptors in the pathogenesis of cardiovascular diseases, and highlight novel strategies and targets for the prevention and treatment of cardiovascular diseases.
|
31555545 |
2019 |
|
Cardiovascular Diseases
|
0.130 |
GeneticVariation
|
group |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Cardiovascular Diseases
|
0.130 |
GeneticVariation
|
group |
BEFREE |
In conclusion, the CST Ser-364 allele may increase the risk for cardiovascular diseases in Japanese population.
|
26211667 |
2015 |
|
Central neuroblastoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
CASZ1 restoration in NB cells delays NB cell cycle progression.
|
23892435 |
2013 |
|
Central neuroblastoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
However, the key domains by which CASZ1 transcription controls developmental processes and neuroblastoma tumorigenicity have yet to be elucidated.
|
22331471 |
2012 |
|
Central neuroblastoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
Treatment of NB cell lines with the histone deacetylase inhibitor trichostatin A led to increased gene transcription of four of the 30 genes, ERRFI1 (MIG-6), PIK3CD, RBP7 (CRBPIV) and CASZ1, indicating that these genes could be affected by epigenetic downregulation in NBs.
|
17940511 |
2007 |
|
Central neuroblastoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
CASZ1b and CASZ1a expression is coordinately upregulated by the differentiation agent Retinoic Acid, as well as agents that modify the epigenome in neural crest derived neuroblastoma cell lines.
|
21490919 |
2011 |
|
Central neuroblastoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Castor zinc finger 1 (CASZ1) is a transcription factor, prominently known for its tumor suppression role in neuroblastoma and other cancers.
|
31481981 |
2019 |