Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.310 GeneticVariation disease BEFREE A predicted miR-330-3p target site SNP (rs41305272) in mitogen-activated protein kinase kinase 5 (MAP2K5) mRNA was in LD (d' = 1.0, r(2) = 0.02) with a reported GWAS-identified variant for restless legs syndrome (RLS), a disorder frequently comorbid with anxiety and depression, possibly because of a shared pathophysiology. 24436253 2014
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 GeneticVariation disease BEFREE In the German sample, variants in MEIS1 and BTBD9 were associated with RLS in ESRD (P(nom)≤0.004, ORs 1.52 and 1.55), whereas, in the Greek sample, there was a trend for association to MAP2K5/SKOR1 and BTBD9 (P(nom)≤0.08, ORs 1.41 and 1.33). 21572129 2011
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 GeneticVariation disease GWASCAT Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. 29029846 2017
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 GeneticVariation disease GWASCAT Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. 17637780 2007
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 GeneticVariation disease GWASDB Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. 21779176 2011
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 GeneticVariation disease BEFREE In a genome-wide association study we found highly significant associations between RLS and intronic variants in the homeobox gene MEIS1, the BTBD9 gene encoding a BTB(POZ) domain as well as variants in a third locus containing the genes encoding mitogen-activated protein kinase MAP2K5 and the transcription factor LBXCOR1 on chromosomes 2p, 6p and 15q, respectively. 17637780 2007
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 GeneticVariation disease BEFREE Genetic risk variants for RLS have recently been identified in two genes, one of them the homeobox gene MEIS1, known to be involved in embryonic development and variants in a second locus containing the genes encoding mitogen-activated protein kinase MAP2K5, and the transcription factor LBXCOR1. 18081164 2007
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 GeneticVariation disease BEFREE A predicted miR-330-3p target site SNP (rs41305272) in mitogen-activated protein kinase kinase 5 (MAP2K5) mRNA was in LD (d' = 1.0, r(2) = 0.02) with a reported GWAS-identified variant for restless legs syndrome (RLS), a disorder frequently comorbid with anxiety and depression, possibly because of a shared pathophysiology. 24436253 2014
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 GeneticVariation disease GWASCAT Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1. 21779176 2011
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 GeneticVariation disease GWASDB Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. 17637780 2007
CUI: C0035258
Disease: Restless Legs Syndrome
Restless Legs Syndrome 		0.190 GeneticVariation disease BEFREE Restless legs syndrome (RLS) is associated with common variants in three intronic and intergenic regions in MEIS1, BTBD9, and MAP2K5/LBXCOR1 on chromosomes 2p, 6p and 15q. 19279021 2009
CUI: C0028754
Disease: Obesity
Obesity 		0.140 GeneticVariation disease BEFREE rs2241423 was associated with BMI and obesity in two independent European cohorts suggesting a role for MAP2K5 in early weight regulation. 22594783 2012
CUI: C0028754
Disease: Obesity
Obesity 		0.140 GeneticVariation disease BEFREE Eight loci, rs10968576 (BDNF), rs3817334 (MTCH2), rs1558902 (FTO), rs571312 (MC4R), rs543874 (SEC16B), rs987237 (TFAP2B), rs2867125 (TMEM18) and rs7138803 (FAIM2), were previously known obesity susceptibility loci, and the remaining four loci, rs1514175 (TNNI3K), rs206936 (NUDT3), rs4771122 (MTIF3) and rs2241423 (MAP2K5), were newly identified as BMI loci by the GIANT study. 22041983 2012
CUI: C0028754
Disease: Obesity
Obesity 		0.140 GeneticVariation disease BEFREE Association (Bonferroni corrected) of rs543874 near SEC16B and rs2241423 near MAP2K5 had presumably stronger effects on obesity in Chinese children than in Caucasian populations. 26800887 2016
CUI: C0028754
Disease: Obesity
Obesity 		0.140 GeneticVariation disease GWASDB Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. 23563607 2013
CUI: C0028754
Disease: Obesity
Obesity 		0.140 GeneticVariation disease GWASCAT Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. 23563607 2013
CUI: C0028754
Disease: Obesity
Obesity 		0.140 GeneticVariation disease BEFREE After adjusting for age, sex and multiple testing, MC4R rs17782313, SEC16B rs543874, MAP2K5 rs2241423 and KCTD15 rs11084753 were associated with obesity and obesity-related traits (all P<0.005), with odd ratios ranging from 1.22 to 2.15. 25637721 2015
CUI: C0005893
Disease: Body mass index procedure
Body mass index procedure 		0.100 GeneticVariation phenotype GWASDB Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. 23001569 2013
CUI: C0005893
Disease: Body mass index procedure
Body mass index procedure 		0.100 GeneticVariation phenotype GWASDB Meta-analysis identifies common variants associated with body mass index in east Asians. 22344219 2012
CUI: C0005893
Disease: Body mass index procedure
Body mass index procedure 		0.100 GeneticVariation phenotype GWASDB Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. 24861553 2014
CUI: C0005893
Disease: Body mass index procedure
Body mass index procedure 		0.100 GeneticVariation phenotype GWASDB Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. 20935630 2010
CUI: C0026603
Disease: Motion Sickness
Motion Sickness 		0.100 GeneticVariation disease GWASCAT Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis. 25628336 2015
CUI: C0037369
Disease: Smoking
Smoking 		0.100 GeneticVariation phenotype GWASCAT Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. 28443625 2017
CUI: C0037369
Disease: Smoking
Smoking 		0.100 GeneticVariation phenotype GWASCAT Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. 30643258 2019
CUI: C0455829
Disease: Waist Circumference
Waist Circumference 		0.100 GeneticVariation phenotype GWASCAT New genetic loci link adipose and insulin biology to body fat distribution. 25673412 2015