|
Restless Legs Syndrome
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
Restless legs syndrome (RLS) is associated with common variants in three intronic and intergenic regions in MEIS1, BTBD9, and MAP2K5/LBXCOR1 on chromosomes 2p, 6p and 15q.
|
19279021 |
2009 |
|
Restless Legs Syndrome
|
0.190 |
Biomarker
|
disease |
BEFREE |
Restless legs syndrome (RLS) is considered a genetic disease and, following a genome-wide association study conducted in 2007, the mitogen-activated protein kinase 5 (MAP2K5) gene has been regarded as the promising candidate gene for RLS.
|
29422930 |
2018 |
|
Metastatic Prostate Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion.
|
12618764 |
2003 |
|
Metastasis from malignant tumor of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion.
|
12618764 |
2003 |
|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
MEK5 transfection experiments confirm its ability to induce proliferation (P < 0.0001), motility (P = 0.0001) and invasion in prostate cancer cells (P = 0.0001).
|
12618764 |
2003 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
MEK5 may be one of the Stat3-regulated genes and plays its essential roles in oncogenesis mediated by aberrantly activated Stat3 signaling in breast carcinomatosis and malignancies.
|
15378007 |
2004 |
|
Carcinomatosis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
MEK5 may be one of the Stat3-regulated genes and plays its essential roles in oncogenesis mediated by aberrantly activated Stat3 signaling in breast carcinomatosis and malignancies.
|
15378007 |
2004 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
MEK5 may be one of the Stat3-regulated genes and plays its essential roles in oncogenesis mediated by aberrantly activated Stat3 signaling in breast carcinomatosis and malignancies.
|
15378007 |
2004 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MEK5 overexpression is associated with the occurrence and development of colorectal cancer.
|
27160304 |
2016 |
|
Obesity
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
rs2241423 was associated with BMI and obesity in two independent European cohorts suggesting a role for MAP2K5 in early weight regulation.
|
22594783 |
2012 |
|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.
|
30108127 |
2018 |
|
Depressive disorder
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
A predicted miR-330-3p target site SNP (rs41305272) in mitogen-activated protein kinase kinase 5 (MAP2K5) mRNA was in LD (d' = 1.0, r(2) = 0.02) with a reported GWAS-identified variant for restless legs syndrome (RLS), a disorder frequently comorbid with anxiety and depression, possibly because of a shared pathophysiology.
|
24436253 |
2014 |
|
Restless Legs Syndrome
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
A predicted miR-330-3p target site SNP (rs41305272) in mitogen-activated protein kinase kinase 5 (MAP2K5) mRNA was in LD (d' = 1.0, r(2) = 0.02) with a reported GWAS-identified variant for restless legs syndrome (RLS), a disorder frequently comorbid with anxiety and depression, possibly because of a shared pathophysiology.
|
24436253 |
2014 |
|
Anxiety
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A predicted miR-330-3p target site SNP (rs41305272) in mitogen-activated protein kinase kinase 5 (MAP2K5) mRNA was in LD (d' = 1.0, r(2) = 0.02) with a reported GWAS-identified variant for restless legs syndrome (RLS), a disorder frequently comorbid with anxiety and depression, possibly because of a shared pathophysiology.
|
24436253 |
2014 |
|
Anxiety Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
A predicted miR-330-3p target site SNP (rs41305272) in mitogen-activated protein kinase kinase 5 (MAP2K5) mRNA was in LD (d' = 1.0, r(2) = 0.02) with a reported GWAS-identified variant for restless legs syndrome (RLS), a disorder frequently comorbid with anxiety and depression, possibly because of a shared pathophysiology.
|
24436253 |
2014 |
|
Mental Depression
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A predicted miR-330-3p target site SNP (rs41305272) in mitogen-activated protein kinase kinase 5 (MAP2K5) mRNA was in LD (d' = 1.0, r(2) = 0.02) with a reported GWAS-identified variant for restless legs syndrome (RLS), a disorder frequently comorbid with anxiety and depression, possibly because of a shared pathophysiology.
|
24436253 |
2014 |
|
Depressed mood
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
A predicted miR-330-3p target site SNP (rs41305272) in mitogen-activated protein kinase kinase 5 (MAP2K5) mRNA was in LD (d' = 1.0, r(2) = 0.02) with a reported GWAS-identified variant for restless legs syndrome (RLS), a disorder frequently comorbid with anxiety and depression, possibly because of a shared pathophysiology.
|
24436253 |
2014 |
|
Depressive disorder
|
0.310 |
Biomarker
|
disease |
PSYGENET |
A predicted miR-330-3p target site SNP (rs41305272) in mitogen-activated protein kinase kinase 5 (MAP2K5) mRNA was in LD (d' = 1.0, r(2) = 0.02) with a reported GWAS-identified variant for restless legs syndrome (RLS), a disorder frequently comorbid with anxiety and depression, possibly because of a shared pathophysiology.
|
24436253 |
2014 |
|
Carcinogenesis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
Abnormal intracellular signaling contributes to carcinogenesis and may represent novel therapeutic targets. mitogen/extracellular signal-regulated kinase kinase-5 (MEK5) overexpression is associated with aggressive prostate cancer.
|
18071319 |
2008 |
|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Additionally, the relationship between TNF-alpha resistance mediated by MEK5/Erk5 signaling and epithelial-mesenchymal transition (EMT), a process associated with promotion of invasion, metastasis, and recurrence in breast cancer, has not previously been investigated.
|
19087274 |
2008 |
|
Obesity
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for age, sex and multiple testing, MC4R rs17782313, SEC16B rs543874, MAP2K5 rs2241423 and KCTD15 rs11084753 were associated with obesity and obesity-related traits (all P<0.005), with odd ratios ranging from 1.22 to 2.15.
|
25637721 |
2015 |
|
Tumor Cell Invasion
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Analysis of clinical pathology parameters indicated MEK5 overexpression was significantly correlated with the depth of invasion, lymph node metastasis, distant metastasis and histological grade.
|
27160304 |
2016 |
|
Obesity
|
0.140 |
GeneticVariation
|
disease |
BEFREE |
Association (Bonferroni corrected) of rs543874 near SEC16B and rs2241423 near MAP2K5 had presumably stronger effects on obesity in Chinese children than in Caucasian populations.
|
26800887 |
2016 |
|
Body mass index procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
|
20935630 |
2010 |
|
Finding of body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
|
20935630 |
2010 |