Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
The overexpression of MEK5 in APO- MCF-7 breast carcinoma cells shows that this MAPK signaling protein represents a potent survival molecule.
|
12219026 |
2002 |
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Taken together, our results establish MEK5 as a key signalling molecule associated with prostate carcinogenesis.
|
12618764 |
2003 |
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
MEK5 transfection experiments confirm its ability to induce proliferation (P < 0.0001), motility (P = 0.0001) and invasion in prostate cancer cells (P = 0.0001).
|
12618764 |
2003 |
Malignant neoplasm of prostate
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We demonstrated that MEK5 expression is increased in prostate cancer as compared to benign prostatic tissue.
|
12618764 |
2003 |
Prostate carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We demonstrated that MEK5 expression is increased in prostate cancer as compared to benign prostatic tissue.
|
12618764 |
2003 |
Prostatic Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion.
|
12618764 |
2003 |
Secondary malignant neoplasm of bone
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Strong MEK5 expression correlates with the presence of bony metastases and less favourable disease-specific survival.
|
12618764 |
2003 |
Metastatic Prostate Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion.
|
12618764 |
2003 |
Metastasis from malignant tumor of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion.
|
12618764 |
2003 |
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
MEK5 may be one of the Stat3-regulated genes and plays its essential roles in oncogenesis mediated by aberrantly activated Stat3 signaling in breast carcinomatosis and malignancies.
|
15378007 |
2004 |
Breast Carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Compared with nonmalignant breast epithelial cells or normal tissues without constitutively active Stat3 signaling, MEK5 protein levels are remarkably higher in breast carcinoma cell lines and cancer tissues with constitutively activated Stat3.
|
15378007 |
2004 |
Malignant neoplasm of breast
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We also investigated MEK5 expression in different breast carcinoma cell lines and breast cancer tissues using tissue array analysis.
|
15378007 |
2004 |
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
MEK5 may be one of the Stat3-regulated genes and plays its essential roles in oncogenesis mediated by aberrantly activated Stat3 signaling in breast carcinomatosis and malignancies.
|
15378007 |
2004 |
Carcinomatosis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
MEK5 may be one of the Stat3-regulated genes and plays its essential roles in oncogenesis mediated by aberrantly activated Stat3 signaling in breast carcinomatosis and malignancies.
|
15378007 |
2004 |
Malignant neoplasm of prostate
|
0.040 |
Biomarker
|
disease |
BEFREE |
Recently, MEK5 has been shown to overexpress in prostate cancer and is associated with poor survival outcome.
|
15805119 |
2005 |
Prostate carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Recently, MEK5 has been shown to overexpress in prostate cancer and is associated with poor survival outcome.
|
15805119 |
2005 |
Medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Only those cells expressing MAP/ERK kinase 5 (MEK5) plus ERK5 or MEF2 constructs underwent apoptosis, indicating that overexpression of either is sufficient to induce medulloblastoma cell death.
|
15994942 |
2005 |
Childhood Medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Only those cells expressing MAP/ERK kinase 5 (MEK5) plus ERK5 or MEF2 constructs underwent apoptosis, indicating that overexpression of either is sufficient to induce medulloblastoma cell death.
|
15994942 |
2005 |
Adult Medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Only those cells expressing MAP/ERK kinase 5 (MEK5) plus ERK5 or MEF2 constructs underwent apoptosis, indicating that overexpression of either is sufficient to induce medulloblastoma cell death.
|
15994942 |
2005 |
androgen independent prostate cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Therefore, we examined the endogenous expression status of MEK5 in androgen-independent prostate cancer cells upon recombinant adenovirus-mediated introduction of MBP-1.
|
15805119 |
2005 |
Restless Legs Syndrome
|
0.190 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.
|
17637780 |
2007 |
Restless Legs Syndrome
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
In a genome-wide association study we found highly significant associations between RLS and intronic variants in the homeobox gene MEIS1, the BTBD9 gene encoding a BTB(POZ) domain as well as variants in a third locus containing the genes encoding mitogen-activated protein kinase MAP2K5 and the transcription factor LBXCOR1 on chromosomes 2p, 6p and 15q, respectively.
|
17637780 |
2007 |
Restless Legs Syndrome
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
Genetic risk variants for RLS have recently been identified in two genes, one of them the homeobox gene MEIS1, known to be involved in embryonic development and variants in a second locus containing the genes encoding mitogen-activated protein kinase MAP2K5, and the transcription factor LBXCOR1.
|
18081164 |
2007 |
Restless Legs Syndrome
|
0.190 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.
|
17637780 |
2007 |
Malignant neoplasm of prostate
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our data show that induction of MEK5/ERK5 signalling is linked to activation of the DNA replication licensing pathway in PCa, and that the strong prognostic value of MCM proteins may result from their function as relay stations coupling growth regulatory pathways to genome duplication.
|
17406359 |
2007 |