PRL, prolactin, 5617

N. diseases: 506; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0878676
Disease: 6-pyruvoyl-tetrahydropterin synthase deficiency
6-pyruvoyl-tetrahydropterin synthase deficiency 		0.010 AlteredExpression disease BEFREE A case of 6-pyruvoyl-tetrahydropterin synthase deficiency demonstrates a more significant correlation of L-Dopa dosage with serum prolactin levels than CSF homovanillic acid levels. 17590551 2008
CUI: C0000744
Disease: Abetalipoproteinemia
Abetalipoproteinemia 		0.010 GeneticVariation disease BEFREE To determine whether a complete deficiency of plasma LDL affects serum concentrations of progesterone (particularly during the luteal phase) or those of other hormones, we have measured the serum concentrations of luteinizing hormone, follicle-stimulating hormone, prolactin, estradiol, estrone, and progesterone during the menstrual cycle in a patient with phenotypic abetalipoproteinemia (on the basis of homozygous hypobetalipoproteinemia). 6959145 1982
CUI: C0158489
Disease: Acquired clubfoot
Acquired clubfoot 		0.010 Biomarker disease BEFREE There was only one malformation (club foot) recorded (3.1%) and normalisation of prolactin after pregnancy without medical treatment occurred in 12% of patients. 28704852 2017
CUI: C0001206
Disease: Acromegaly
Acromegaly 		0.050 Biomarker disease BEFREE Although samples from the initial surgery were positive for prolactin and negative for GH, about 10% of GH-positive cells were detected in tissue from the last surgery, consistent with the observed clinical shift to acromegaly. 19890024 2010
CUI: C0001206
Disease: Acromegaly
Acromegaly 		0.050 AlteredExpression disease BEFREE Despite suppression of prolactin levels with cabergoline, the pituitary tumor continued to increase in size and the patient developed clinical symptoms and biochemistry consistent with the diagnosis of acromegaly due to acidophilic stem cell adenoma, an extremely rare subtype of mixed growth hormone/prolactin adenoma, which behaves more aggressively and has a lower surgical cure rate compared to the pure GH-secreting adenoma. 31721135 2019
CUI: C0001206
Disease: Acromegaly
Acromegaly 		0.050 Biomarker disease BEFREE Of the eight patients with pituitary tumors, seven had high serum prolactin and responded to bromocriptine therapy, whereas the eighth patient had acromegaly treated with radiotherapy. 2568165 1989
CUI: C0001206
Disease: Acromegaly
Acromegaly 		0.050 Biomarker disease BEFREE In the present study, the authors analyzed polysialylated NCAM expression in 82 pituitary tumors from humans: 49 secreting adenomas, 32 nonfunctioning adenomas, and one growth hormone and prolactin-secreting carcinoma associated with acromegaly and spinal and liver metastases. 12744370 2003
CUI: C0001206
Disease: Acromegaly
Acromegaly 		0.050 Biomarker disease BEFREE Three patients with pituitary tumors showed variability in terms of tumor phenotype (two with acromegaly, one with prolactinoma, or mixed prolactin/GH-secreting tumor) and age at diagnosis; both patients with acromegaly had poor responses to octreotide. 17893251 2007
CUI: C0342442
Disease: ACTH-dependent Cushing's syndrome
ACTH-dependent Cushing's syndrome 		0.010 Biomarker disease BEFREE Our objective was to assess the effect of using prolactin to confirm adequacy of petrosal cannulation in a cohort of patients with ACTH-dependent Cushing's syndrome. 28626863 2017
CUI: C0001403
Disease: Addison Disease
Addison Disease 		0.020 AlteredExpression disease BEFREE Reduction in pituitary tumour volume and brisk fall in serum prolactin in response to low-dose cabergoline is regularly observed in patients with macroprolactinomas, but the concurrent fall in the plasma ACTH level and hypocortisolism was a pleasant surprise. 28784879 2017
CUI: C0001403
Disease: Addison Disease
Addison Disease 		0.020 AlteredExpression disease BEFREE Phenotypic variability was observed among patients with the same mutations, particularly the presence and age of onset of hypocortisolism, the levels of PRL and the results of pituitary imaging. 16984240 2006
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.310 Biomarker group CTD_human Two continuous lines, BL-MaTU/A1 and BL-MaTU/s6, were established from C57Bl/10 mammary adenocarcinomas induced by DMBA-prolactin-estradiol treatment. 6280079 1981
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.310 Biomarker group BEFREE Like a subset of ERα<sup>+</sup> patient cancers, the prolactin-induced adenocarcinomas contained two major tumor subpopulations that expressed markers of normal luminal and basal epithelial cells. 29363543 2018
CUI: C1319315
Disease: Adenocarcinoma of large intestine
Adenocarcinoma of large intestine 		0.010 Biomarker disease BEFREE Ectopic production of prolactin by colorectal adenocarcinoma. 11805572 2001
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.010 AlteredExpression disease BEFREE Furthermore, prolactin was overexpressed and portended poor prognosis in human LADC. 30828726 2019
CUI: C0854988
Disease: Adenocarcinoma of lung, stage IV
Adenocarcinoma of lung, stage IV 		0.010 Biomarker disease BEFREE Prolactin-Secreting Lung Adenocarcinoma Metastatic to the Pituitary Mimicking a Prolactinoma: A Case Report. 30137505 2019
CUI: C0205641
Disease: Adenocarcinoma, Basal Cell
Adenocarcinoma, Basal Cell 		0.300 Biomarker disease CTD_human Organization of proviral DNA and protein composition of hormonally stimulated C57Bl/10 strain-associated mouse mammary tumor virus. 6280079 1981
CUI: C0205642
Disease: Adenocarcinoma, Oxyphilic
Adenocarcinoma, Oxyphilic 		0.300 Biomarker disease CTD_human Organization of proviral DNA and protein composition of hormonally stimulated C57Bl/10 strain-associated mouse mammary tumor virus. 6280079 1981
CUI: C0205645
Disease: Adenocarcinoma, Tubular
Adenocarcinoma, Tubular 		0.300 Biomarker disease CTD_human Organization of proviral DNA and protein composition of hormonally stimulated C57Bl/10 strain-associated mouse mammary tumor virus. 6280079 1981
CUI: C0001430
Disease: Adenoma
Adenoma 		0.400 Biomarker group BEFREE Because human epidermal growth factor receptor 2 (HER2)/ErbB2 is overexpressed in prolactinomas and ErbB receptor ligands regulate prolactin (PRL) gene expression, we tested the role of HER2/ErbB2 in prolactinoma hormone regulation and adenoma cell proliferation to assess the rationale for targeting this receptor for prolactinoma therapy. 21106881 2011
CUI: C0001430
Disease: Adenoma
Adenoma 		0.400 AlteredExpression group BEFREE Thus, the study of PRL gene expression and immunohistochemistry in GH-secreting adenomas is valuable to understanding the pathophysiology of pituitary tumors. 2338572 1990
CUI: C0001430
Disease: Adenoma
Adenoma 		0.400 AlteredExpression group BEFREE A significantly higher content of CRABP1 mRNA was observed in NFPA compared to functioning adenomas, and PRL-secreting adenomas showed a lower expression of this gene compared to normal pituitary. 21270509 2011
CUI: C0001430
Disease: Adenoma
Adenoma 		0.400 Biomarker group BEFREE In addition,1 of 2 ACTH tumors but no GH (n = 4) or PRL (n = 1) adenoma examined were hypermethylated. 11740049 2001
CUI: C0001430
Disease: Adenoma
Adenoma 		0.400 Biomarker group BEFREE Pit-1 mRNA was detected in 12 (80%) of 15 prolactin-producing adenomas. 8733768 1996
CUI: C0001430
Disease: Adenoma
Adenoma 		0.400 AlteredExpression group BEFREE At last assessment (median follow-up 3 years) and compared with values 6-12 months after stopping DA, Prolactin (PRL) increased in 15%, decreased but not normalized in 33% and was normal in 52%; PRL levels or visible adenoma on imaging before DA withdrawal, treatment duration and presence of macro-/microadenoma at diagnosis were not predictors of normoprolactinaemia at last review, whereas PRL values 6-12 months after stopping DA were. 29894000 2018