|
Somatotropin deficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Analyzes of BMI-adjusted GH levels, revealed that 14% of patients were GHD.These patients had higher prolactin.
|
31661639 |
2020 |
|
Hypophysitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Anti-PIT-1 hypophysitis (anti-PIT-1 antibody syndrome) is a newly described pituitary autoimmune disease characterized by acquired and specific growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH) deficiencies.
|
31513261 |
2020 |
|
Pancreatic Ductal Adenocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Patients with pancreatic ductal adenocarcinoma (PDAC) have high plasma levels of PRL.
|
31786131 |
2020 |
|
Mixed Somatotroph and Lactotroph Adenoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Chronic hypertension, dizziness, and vertigo prompted an endocrine workup which revealed elevated IGF-1 and prolactin; The pituitary mass proved to be a mixed somatotroph/lactotroph adenoma.
|
31769844 |
2020 |
|
Affective Disorders, Psychotic
|
0.010 |
AlteredExpression
|
group |
BEFREE |
There is a discrepancy in literature regarding level of prolactin in drug free/ drug naïve patients with non-affective psychosis.
|
30453151 |
2019 |
|
Alopecia Areata
|
0.010 |
Biomarker
|
disease |
BEFREE |
Do Prolactin and its Receptor Play a Role in Alopecia Areata?
|
29937561 |
2019 |
|
Drug abuse
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The aim of this study was to investigate postmortem PRL levels as potential markers of drug abuse, especially that of DA antagonists, in autopsy cases.
|
31319705 |
2019 |
|
Empty Sella Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
We enrolled 149 patients (108 F/41 M) with PRLs (110 micro/39 macro) and 143 subjects (100 F/43 M) with NFPA (n = 96, 56 micro/40 macro) or ES (n = 47), with normal serum prolactin.
|
30406929 |
2019 |
|
Encephalomyelitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, PRL levels in the cerebrospinal fluid were significantly increased in the late phase of EAE, and blocking the production of PRL by bromocriptine or Zbtb20-specific siRNA significantly reduced the numbers of Eomes<sup>+</sup> Th cells in the central nervous system (CNS) and ameliorated clinical signs in the later phase of EAE.
|
31570595 |
2019 |
|
Fatigue
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The ACTH and PRL responses to the first and second exercise tests and feeling of fatigue were the most discriminating variables.
|
31274684 |
2019 |
|
Hypercholesterolemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The total cholesterol (baseline, 236.1 ± 47.6 mg/dl; endpoint [week 12], 209.9 ± 28.0 mg/dl; p = 0.005) and prolactin levels (baseline, 80.0 ± 85.2 ng/ml; endpoint [week 12], 63.2 ± 88.9 ng/ml; p = 0.003) were also significantly improved in patients with hypercholesterolemia or hyperprolactinemia.
|
31352709 |
2019 |
|
Icterus
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Jaundice is a common neonatal problem.This study was conducted to determine the effect of metoclopramide on neonatal bilirubin and maternal prolactin (primary outcomes) and milk volume (secondary outcome).
|
30519818 |
2019 |
|
Neonatal Jaundice
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Metoclopramide increased maternal serum prolactin but had no effects on neonatal jaundice.
|
30519818 |
2019 |
|
Mitral Valve Stenosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
ROC curve analysis, PRL ≥123 had 71% sensitivity and 52% specificity in predicting SEC in patients with MS.
|
31002186 |
2019 |
|
Prader-Willi Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
GH and prolactin contents in PWS-ICdel pituitaries were reduced in proportion to their smaller pituitary size, with circulating IGF-1 concentration reduced by 37-47%.
|
31454785 |
2019 |
|
Seizures
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Recent evidence points PRL receptor (PRL-R) as mediator of such neuroprotective effects and seizures as regulators of neuronal marker transcript expression in the hippocampus.
|
30500398 |
2019 |
|
Sleep disturbances
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Recent studies have found altered levels of FSH, LH, and prolactin with sleep disturbance or circadian dysrhythmia.
|
31644470 |
2019 |
|
Vitiligo
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, enrichment analysis suggested that targets of KBL on vitiligo were mainly clustered into multiple biological processes (associated with DNA translation, lymphocyte differentiation and activation, steroid biosynthesis, autoimmune and systemic inflammatory reaction, neuron apoptosis, and vitamin deficiency) and related pathways (TNF, JAK-STAT, ILs, TLRs, prolactin, and NF-<i>κ</i>B), indicating the underlying mechanisms of KBL on vitiligo.
|
31781265 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, prolactin was overexpressed and portended poor prognosis in human LADC.
|
30828726 |
2019 |
|
Gastroparesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Metoclopramide (MCA; the only US Food and Drug Administration-approved for gastroparesis) has the ability to restore immune function through increasing prolactin secretion.
|
31040663 |
2019 |
|
Anhedonia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The bipolar group had significantly lower lipid levels (including triglycerides, cholesterol, low-density lipoprotein cholesterol [LDL], very low-density lipoprotein cholesterol [VLDL]) and insulin resistance index but higher levels of prolactin, low triiodothyronine (T3) and free T3 (FT3) as well as higher incidence of anhedonia as compared with the unipolar group.
|
31747876 |
2019 |
|
Depression, Postpartum
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using this data, we generated polygenic risk scores (PRS) for estradiol, progesterone, prolactin and testosterone in the European RADIANT cohort consisting of 176 postpartum depression (PPD) cases (100% female, mean age: 41.6 years old), 2772 major depressive disorder (MDD) cases (68.6% female, mean age: 46.9 years old) and 1588 control participants (62.5% female, mean age: 42.4 years old), for which there was also a neuroimaging subset of 111 individuals (60.4% female, mean age: 50.0 years old).
|
31039525 |
2019 |
|
Drug usage
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Evaluation of screening for drug use using postmortem prolactin levels in serum and cerebrospinal fluid.
|
31319705 |
2019 |
|
Rheumatic mitral stenosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
ROC curve analysis, PRL ≥123 had 71% sensitivity and 52% specificity in predicting SEC in patients with MS.
|
31002186 |
2019 |
|
Idiopathic hyperprolactinemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cabergoline therapy was significantly more effective in patient with idiopathic hyperprolactinemia than prolactinoma patients with regard to BMI, waist circumference, HDLc and visceral adiposity index despite normalization of prolactin levels in both groups.
|
30806330 |
2019 |